Observation of Blood Donor-Recipient Malaria Parasitaemia Patterns in a Malaria Endemic Region

Background. Asymptomatic malaria parasitaemia has been documented in donor blood in West Africa. However, donated blood is not routinely screened for malaria parasites (MPs). The present study therefore aimed to document the frequency of blood transfusion-induced donor-recipient malaria parasitaemia patterns, in children receiving blood transfusion in a tertiary health-centre. Methodology. A cross-sectional, observational study involving 140 children receiving blood transfusion was carried out. Blood donor units and patients’ blood samples were obtained, for the determination of malaria parasites (MPs). Giemsa staining technique was used to determine the presence of malaria parasitaemia. Results. Malaria parasites were detected in 7% of donor blood and in 8.3% of the recipients’ pretransfusion blood. The incidence of posttransfusion MPs was 3%, but none of these were consistent with blood transfusion-induced malaria, as no child with posttransfusion parasitaemia was transfused with parasitized donor blood. Majority of the blood transfusions (89.4%) had no MPs in either donors or recipients, while 6.8% had MPs in both donors and recipients, with the remaining 3.8% showing MPs in recipients alone. Conclusion. In conclusion, the incidence of posttransfusion malaria parasitaemia appears low under the prevailing circumstances

The use of hydroxycarbamide in children with sickle cell anemia

Background: Although hydroxycarbamide (hydroxyurea [HU]) has been in use for decades in both adults and child populations with sickle cell disease (SCD), its reported use has remained low in Africa and Nigeria where the largest number of SCD patients reside. Availability, cost, and concerns about safety and efficacy are some of the challenges to its use. Objectives: This study highlights the experience of using HU for children with sickle cell anemia in Ahmadu Bello University Teaching Hospital, Zaria. Materials and Methods: A descriptive, retrospective observational study of children is presented. Demographic, clinical, and laboratory features of children on HU, the indications for therapy and adverse clinical events encountered were analyzed. Results: A total of 165 children were treated with HU over a 4-year period, their ages ranging between 0.9 and 17 years. A total of 85 (47.5%) had HU for >12 months, while 61 (34.1%) were on treatment <11 months, while 19 (10.2%) were lost to follow-up. There was a significant increase in the weight, height, fetal hemoglobin, mean corpuscular volume, and a significant reduction in white cell counts; with no differences in the packed cell volume, hemoglobin concentration, creatinine, alanine transaminase, and bilirubin levels. Adverse events and/or comorbidities were reported in 48 (56.5%) patients, while one patient discontinued treatment because of skin rash. Conclusion: This study highlights the increased utilization of HU among children in an African region, the observed clinical events, and laboratory parameters. The benefits are demonstrable, and the drug-related organ toxicities appear minimal

Performance of school health programme in Nigeria: A situation analysis

Background: School Health Programme (SHP) if effectively implemented, will contribute to the optimal health of schoolchildren. In this survey, the extent of the implementation of SHP in Nigeria was evaluated. Methods: The study was crosssectional nationwide, school-based survey, and schools were randomly selected. The school proprietors, school health personnel, teachers, students, and parents were interviewed using an interviewer- administered questionnaire on the key components of SHP. Results: A total of 105 schools were surveyed. The proportion of students, teachers and parents who were aware of SHP were 26.3%, 11.1% and 9.10%, respectively. The proportion of the schools which conduct mental health, nutritional assessment and visual & hearing screening were 48.6%, 51.4%, and 57.1%, respectively. There were 18 (17.6%) schools that had trained person in charge of the health of students. Schools that still use pit toilet and open defecation method were 22.9% and 11.3%, respectively. The proportion of school with retainership with a health facility was 37.1%. Conclusion: The SHP awareness is poor in Nigeria, and its implementation is sub-optimal. There is need for renewed interest in SHP in Nigeria through reform and deliberate interventions especially on establishing school-based vaccination programme and referral of sick pupils to healthcare facility