Effect of soy protein on serum lipid profile and some lipid-metabolizing enzymes in cholesterol fed rats

The effect of soy protein on serum lipid profile and some lipid metabolizing enzymes in rats fed with cholesterol diets was examined in this study. Rats were subjected to feeding trial over a period of sixweeks on formulated diets containing: 20% soy protein with 0% cholesterol (group A), 20% soy protein with 5% cholesterol (group B), 20% soy protein with 10% cholesterol (group C), 0% soy protein with 20% cholesterol (group D), and 5% soy protein with 20% cholesterol (group E). Serum total, VLDL, LDL, and HDL-cholesterol and triglyceride concentrations were found to be reduced significantly in Groups B and C when compared with Groups D and E (p 0.05). Groups D and E showed significant increased levels (p < 0.01) when compared to other groups. Lipoprotein lipase (LPL), lecithin:cholesterol acyl transferase (LCAT), and triglyceride lipase (TGL) activities were found to be significantly reduced (p< 0.05) in groups B and C when compared with groups D and E. Though groups B, C, D, and E rats all showed significant elevation (p < 0.05) in the enzyme activities when compared to the control

PRELIMINARY BIBLIOMETRICS OF PLANT-DERIVED HEALTH FOODS OVER THE LAST DECADE IN THE SCOPUS DATABASE

A growing interest in the medicinal values of foods can be assessed by the rapidity of research publications on foods that exert health benefits. Many foods that are of health benefit to humans, irrespective of their origin (plants, animals) and subjected level of processing (fermentation, cooking, warming, freezing, vacuumpackaging), are variously designated in scientific literature based on their biofunction. Plant-based foods’ application vagaries, momentum, and research orientation regarding their health functionality awareness are scarcely studied by bibliometrics from a global perspective. Therefore, a bibliometric search was performed on the Scopus database from 2011 (January) to 2021 (April) using a range of search keys covering reports of conceptualized consumable plant-derived foods with health-promoting potential. A total of 362,309 documents on medicinal foods of plant origin were obtained from the database. The data were obtained in comma-separated values (CSV) format and analyzed with Microsoft Excel tools. Of the total documents from the Scopus database on the study, 8.01% (29,036) were contributed by African researchers. Comparatively, lead contributors (global; Africa) by group disciplines include biochemistry, genetics, and molecular biology (118,896; 8,236); pharmacology, toxicology, and pharmaceutics (104,530; 8,581); agricultural and biological sciences (99,053; 9,610), respectively. Similarly, lead contributors by country include China (73,977), India (44,898), USA (44,582), and Nigeria (4,680). This observation shows a higher research propensity towards plant-derived medicinal foods in populous nations due to factors like dietary culture, an increase in vegan and health-nutrition enthusiast populations, and the emergent concerns with the therapeutic use of synthetic pharmaceuticals. The analyzed results gave insights into the research orientation of plant-based foods that promote human health on a global stage and provide future research directions. Knowledge of the various application of plant-based foods may potentiate the United Nations Sustainable Goals initiative on responsible consumption (SDG 12), and health and wellbeing (SDG 3) among the global population

Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice

Abstract Bioactive components of Ganoderma lucidum has recently gained intense research attention due to their acclaimed nutritional and medicinal properties. Thus, the terpenoid extract from the fruit bodies of G. lucidum (GT) was evaluated for activity against Plasmodium berghei in mice in two separate experiments. In addition, the effects of the extract on erythrocyte and hepatic lipids as well as liver HMG-CoA reductase activity before and after the treatments were also assessed. Mice with established infection were administered 100 and 250 mg/kg/day GT alone and in combination with chloroquine (CQ), in either case two separate controls designated: CQ (30 mg/kg chloroquine) and INF-CTR (1 mL DMSO) were also included. Treatment was administered orally for 12 days and parasitemia determined every three days. Percentage survival was significantly increased to 87% from 66% due to combination of GT100 with CQ compared to GT100 alone and to 75% from 62% when GT250 was administered with CQ compared to GT250 alone. Erythrocyte triglycerides, total cholesterol (TC), LDL and phospholipids contents were significantly lower in GT + CQ-treated mice compared to CQ alone and INF-CTR. Similarly, hepatic TC and phospholipid levels were significantly lower in the GT + CQ-treated mice compared to CQ alone and INF-CTR and HMG-CoA reductase activity in the liver was significantly inhibited due to administration of GT + CQ. Data from this study suggest that the anti-plasmodial action of GT could involve mechanisms associated with its hypolipidemic activity. It was also demonstrated that chloroquine, when administered in combination with GT, potentiates its curative effect in P. berghei-infected mice