Investigation of kilovolt ion sputtering Quarterly progress report, May - Jul. 1966

Aluminum sputtering, and neutron activation analysis after cesium ion bombardmen

Nonequilibrium Approach to Bloch-Peierls-Berry Dynamics

We examine the Bloch-Peierls-Berry dynamics under a classical nonequilibrium dynamical formulation. In this formulation all coordinates in phase space formed by the position and crystal momentum space are treated on equal footing. Explicitly demonstrations of the no (naive) Liouville theorem and of the validity of Darboux theorem are given. The explicit equilibrium distribution function is obtained. The similarities and differences to previous approaches are discussed. Our results confirm the richness of the Bloch-Peierls-Berry dynamics

Moving Wigner Glasses and Smectics: Dynamics of Disordered Wigner Crystals

We examine the dynamics of driven classical Wigner solids interacting with quenched disorder from charged impurities. For strong disorder, the initial motion is plastic -- in the form of crossing winding channels. For increasing drive, the disordered Wigner glass can reorder to a moving Wigner smectic -- with the electrons moving in non-crossing 1D channels. These different dynamic phases can be related to the conduction noise and I(V) curves. For strong disorder, we show criticality in the voltage onset just above depinning. We also obtain the dynamic phase diagram for driven Wigner solids and prove that there is a finite threshold for transverse sliding, recently found experimentally.Comment: 4 pages, 4 postscript figure

A consistent derivation of the quark--antiquark and three quark potentials in a Wilson loop context

In this paper we give a new derivation of the quark-antiquark potential in the Wilson loop context. This makes more explicit the approximations involved and enables an immediate extension to the three-quark case. In the $q\overline{q}$ case we find the same semirelativistic potential obtained in preceding papers but for a question of ordering. In the $3q$ case we find a spin dependent potential identical to that already derived in the literature from the ad hoc and non correct assumption of scalar confinement. Furthermore we obtain the correct form of the spin independent potential up to the $1/m^2$ order.Comment: 30 pages, Revtex (3 figures available as hard copies only), IFUM 452/F

Cold atom confinement in an all-optical dark ring trap

We demonstrate confinement of $^{85}$Rb atoms in a dark, toroidal optical trap. We use a spatial light modulator to convert a single blue-detuned Gaussian laser beam to a superposition of Laguerre-Gaussian modes that forms a ring-shaped intensity null bounded harmonically in all directions. We measure a 1/e spin-relaxation lifetime of ~1.5 seconds for a trap detuning of 4.0 nm. For smaller detunings, a time-dependent relaxation rate is observed. We use these relaxation rate measurements and imaging diagnostics to optimize trap alignment in a programmable manner with the modulator. The results are compared with numerical simulations.Comment: 5 pages, 4 figure

Driven vortices in 3D layered superconductors: Dynamical ordering along the c-axis

We study a 3D model of driven vortices in weakly coupled layered superconductors with strong pinning. Above the critical force $F_c$, we find a plastic flow regime in which pancakes in different layers are uncoupled, corresponding to a pancake gas. At a higher $F$, there is an ``smectic flow'' regime with short-range interlayer order, corresponding to an entangled line liquid. Later, the transverse displacements freeze and vortices become correlated along the c-axis, resulting in a transverse solid. Finally, at a force $F_s$ the longitudinal displacements freeze and we find a coherent solid of rigid lines.Comment: 4 pages, 3 postscript figure

Race/ethnicity and disease severity in IgA nephropathy

BACKGROUND: Relatively few U.S.-based studies in chronic kidney disease have focused on Asian/Pacific Islanders. Clinical reports suggest that Asian/Pacific Islanders are more likely to be affected by IgA nephropathy (IgAN), and that the severity of disease is increased in these populations. METHODS: To explore whether these observations are borne out in a multi-ethnic, tertiary care renal pathology practice, we examined clinical and pathologic data on 298 patients with primary glomerular lesions (IgAN, focal segmental glomerulosclerosis, membranous nephropathy and minimal change disease) at the University of California San Francisco Medical Center from November 1994 through May 2001. Pathologic assessment of native kidney biopsies with IgAN was conducted using Haas' classification system. RESULTS: Among individuals with IgAN (N = 149), 89 (60%) were male, 57 (38%) white, 53 (36%) Asian/Pacific Islander, 29 (19%) Hispanic, 4 (3%) African American and 6 (4%) were of other or unknown ethnicity. The mean age was 37 ± 14 years and median serum creatinine 1.7 mg/dL. Sixty-six patients (44%) exhibited nephrotic range proteinuria at the time of kidney biopsy. The distributions of age, gender, mean serum creatinine, and presence or absence of nephrotic proteinuria and/or hypertension at the time of kidney biopsy were not significantly different among white, Hispanic, and Asian/Pacific Islander groups. Of the 124 native kidney biopsies with IgAN, 10 (8%) cases were classified into Haas subclass I, 12 (10%) subclass II, 23 (18%) subclass III, 30 (25%) subclass IV, and 49 (40%) subclass V. The distribution of Haas subclass did not differ significantly by race/ethnicity. In comparison, among the random sample of patients with non-IgAN glomerular lesions (N = 149), 77 (52%) patients were male, 51 (34%) white, 42 (28%) Asian/Pacific Islander, 25 (17%) Hispanic, and 30 (20%) were African American. CONCLUSIONS: With the caveats of referral and biopsy biases, the race/ethnicity distribution of IgAN differs significantly from that of other major glomerulonephridities. However, among individuals undergoing native kidney biopsy, we see no evidence of a race/ethnicity association with severity of disease in IgAN by clinical and IgAN-specific histopathologic criteria. Further studies are needed to identify populations at higher risk for progressive disease in IgAN

Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing

Duchenne muscular dystrophy (DMD) is a fatal muscle disorder characterized by cycles of degeneration and regeneration of multinucleated myofibers and pathological activation of a variety of other muscle-associated cell types. The extent to which different nuclei within the shared cytoplasm of a myofiber may display transcriptional diversity and whether individual nuclei within a multinucleated myofiber might respond differentially to DMD pathogenesis is unknown. Similarly, the potential transcriptional diversity among nonmuscle cell types within dystrophic muscle has not been explored. Here, we describe the creation of a mouse model of DMD caused by deletion of exon 51 of the dystrophin gene, which represents a prevalent disease-causing mutation in humans. To understand the transcriptional abnormalities and heterogeneity associated with myofiber nuclei, as well as other mononucleated cell types that contribute to the muscle pathology associated with DMD, we performed single-nucleus transcriptomics of skeletal muscle of mice with dystrophin exon 51 deletion. Our results reveal distinctive and previously unrecognized myonuclear subtypes within dystrophic myofibers and uncover degenerative and regenerative transcriptional pathways underlying DMD pathogenesis. Our findings provide insights into the molecular underpinnings of DMD, controlled by the transcriptional activity of different types of muscle and nonmuscle nuclei

Bethe--Salpeter equation in QCD

We extend to regular QCD the derivation of a confining $q \bar{q}$ Bethe--Salpeter equation previously given for the simplest model of scalar QCD in which quarks are treated as spinless particles. We start from the same assumptions on the Wilson loop integral already adopted in the derivation of a semirelativistic heavy quark potential. We show that, by standard approximations, an effective meson squared mass operator can be obtained from our BS kernel and that, from this, by ${1\over m^2}$ expansion the corresponding Wilson loop potential can be reobtained, spin--dependent and velocity--dependent terms included. We also show that, on the contrary, neglecting spin--dependent terms, relativistic flux tube model is reproduced.Comment: 23 pages, revte