Temptation: A Biblical and Psychological Approach

Reviewed Book: Oates, Wayne Edward. Temptation: A Biblical and Psychological Approach. Louisville, Ky: Westminster/John Knox Press, 1991

A Neural Network Model for the Development of Simple and Complex Cell Receptive Fields Within Cortical Maps of Orientation and Ocular Dominance

Prenatal development of the primary visual cortex leads to simple cells with spatially distinct and oriented ON and OFF subregions. These simple cells are organized into spatial maps of orientation and ocular dominance that exhibit singularities, fractures, and linear zones. On a finer spatial scale, simple cells occur that are sensitive to similar orientations but opposite contrast polarities, and exhibit both even-symmetric and odd-symmetric receptive fields. Pooling of outputs from oppositely polarized simple cells leads to complex cells that respond to both contrast polarities. A neural network model is described which simulates how simple and complex cells self-organize starting from unsegregated and unoriented geniculocortical inputs during prenatal development. Neighboring simple cells that are sensitive to opposite contrast polarities develop from a combination of spatially short-range inhibition and high-gain recurrent habituative excitation between cells that obey membrane equations. Habituation, or depression, of synapses controls reset of cell activations both through enhanced ON responses and OFF antagonistic rebounds. Orientation and ocular dominance maps form when high-gain medium-range recurrent excitation and long-range inhibition interact with the short-range mechanisms. The resulting structure clarifies how simple and complex cells contribute to perceptual processes such as texture segregation and perceptual grouping.Air Force Office of Scientific Research (F49620-92-J-0334); British Petroleum (BP 89A-1204); National Science Foundation (IRI-90-24877); Office of Naval Research (N00014-91-J-4100); Defense Advanced Research Projects Agency and the Office of Naval Research (N00014-95-1-0409

A History of the American Mind: "Young Goodman Brown"

Cet article, ancré dans la critique littéraire traditionnelle, a pour thèse que la nouvelle “Young Goodman Brown” est un récit historique. Pour être plus précis, cet article peut être considéré comme une relecture historique qui, néanmoins, s’appuie sur les interprétations traditionnelles du texte. Cette association de perspectives témoigne de la richesse du texte et rend évidentes les nouvelles approches historiques de l’auteur lui-même. La thèse de cet article peut se résumer de la façon suivante : "Young Goodman Brown” se penche sur l’impact important que peuvent avoir les influences culturelles sur l’individu, sur l'intériorisation de ces influences par l’individu et enfin sur comment ces influences créent et affectent les relations de cet individu avec sa société. Par extension, cet article analyse la façon dont les idées créent et affectent une société. En résumé, "Young Goodman Brown" est le condensé historique d'une culture, qui est la culture d’une Amérique démocratique et en pleine évolution

A demographic analysis of aging in Missouri

"MP323, 1973

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.

Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential treatment options for Dravet syndrome. To investigate the serotonin receptors that could moderate this antiepileptic activity, we designed and synthesized 28 novel analogues of clemizole, obtained receptor binding affinity profiles, and performed in vivo screening in a scn1lab mutant zebrafish (Danio rerio) model which recapitulates critical clinical features of Dravet syndrome. We discovered three clemizole analogues with 5-HT receptor binding that exert powerful antiepileptic activity. Based on structure-activity relationships and medicinal chemistry-based analysis, we then screened an additional set of known 5-HT receptor specific drug candidates. Integrating our in vitro and in vivo data implicates 5-HT2B receptors as a critical mediator in the mechanism of seizure suppression observed in Dravet syndrome patients treated with 5-HT modulating drugs

A History of the American Mind: "Young Goodman Brown"

Cet article, ancré dans la critique littéraire traditionnelle, a pour thèse que la nouvelle “Young Goodman Brown” est un récit historique. Pour être plus précis, cet article peut être considéré comme une relecture historique qui, néanmoins, s’appuie sur les interprétations traditionnelles du texte. Cette association de perspectives témoigne de la richesse du texte et rend évidentes les nouvelles approches historiques de l’auteur lui-même. La thèse de cet article peut se résumer de la façon suivante : "Young Goodman Brown” se penche sur l’impact important que peuvent avoir les influences culturelles sur l’individu, sur l'intériorisation de ces influences par l’individu et enfin sur comment ces influences créent et affectent les relations de cet individu avec sa société. Par extension, cet article analyse la façon dont les idées créent et affectent une société. En résumé, "Young Goodman Brown" est le condensé historique d'une culture, qui est la culture d’une Amérique démocratique et en pleine évolution

Resonance Suppression in Multi-Degree-of-Freedom Rotating Flexible Structures Using Order-Tuned Absorbers

International audienceThis paper considers the dynamic response and order-tuning of vibration absorbers fitted to a rotating flexible structure under traveling wave (TW) engine order excitation. Of specific interest is the extension of previous results on the so-called no-resonance zone, that is, a region in linear tuning parameter space in which the coupled structure/absorber system does not experience resonance over all rotation speeds. The no-resonance feature was shown to exist for cyclic rotating structures with one structural and one absorber degree-of-freedom (DOF) per sector. This work uses a higher-fidelity structural model to investigate the effects of higher modes on the cyclically-coupled system. It is shown that the no-resonance zone is replaced by a resonance-suppression zone in which one structural mode is suppressed, but higher-order resonances still exist with the addition of the absorbers. The results are general, in the sense that one vibration mode can be eliminated using a set of identically-tuned ab-sorbers on a rotating structure with arbitrarily many DOFs per sector

Panel II: Presidential Lawmaking Powers: Vetoes, Line Item Vetoes, Signing Statements, Executive Orders, and Delegations of Rulemaking Authority

My topic is the delegation of legislative power which occurs when a statute authorizes the Executive to make the rules of conduct. My purpose is to urge you to begin to rethink whether this prevalent practice is a wise and good thing