Florian Hladik and Charlene Dezzutti discuss a macaque study of whether rectal simian immunodeficiency virus transmission can be prevented by topical pre-exposure application of tenofovir gel

Charlene S Dezzutti

Cohen

Cranage

de Witte

Denton

Florian Hladik

Fuchs

Garc&iacute

Hladik

Munch

Neurath

Olshansky-Feddes

Patel

Van Damme

van de Wijgert

Public Library of Science (PLOS)

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PubMed Central

English

AIDS research. Microbicide fails to protect against HIV.

Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of

Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised controlled trial.

Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: Potential implication for HIV transmission.

Impact of semen on HIV-1 infection and in vitro antiviral activity of topical microbicides [abstract TA-215]. Microbicides

Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1.

Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.

Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir .

Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.

Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides.

Semen-derived amyloid fibrils drastically enhance HIV infection.

Seminal plasma reduces the effectiveness of topical polyanionic microbicides.

Vaginal microbicides: moving ahead after an unexpected setback.

Can a Topical Microbicide Prevent Rectal HIV Transmission?