7 research outputs found

    Play and the Creative Arts

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    The author’s view is that the child's participation in pretence play changes the state of his mind, and plunge him into a kind of a light hypnotic trance. The child’s view seems to become inward-looking, introspective, which allows him to protect his inner world from the surrounding reality. Children are easily controlling the process of transition into the playing state and coming back to reality and they are aware that nothing magical happens to them during the play. At the same time, they are in desperate need of this kind of game protection of their internal world in which reality is creatively transformed by them into something else that has a strictly individual value for each individual child, and therefore extremely valuable for him or her and absolutely necessary for the personal developmen

    The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis

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    Aims A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). Methods and results We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF = 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28%), and have a history of hypertension (51 vs. 41%). Ischaemic aetiology was less common (43 vs. 59%) in patients with HF-PEF. There were 121 [95% confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95% CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95% CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40%. Conclusion Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis

    Pathogenesis of Diabetes-Induced Congenital Malformations

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