Verification and validation of the high-performance Lorentz-Orbit Code for Use in Stellarators and Tokamaks (LOCUST)

| openaire: EC/H2020/633053/EU//EUROfusionA novel high-performance computing algorithm, developed in response to the next generation of computational challenges associated with burning plasma regimes in ITER-scale tokamak devices, has been tested and is described herein. The Lorentz-orbit code for use in stellarators and tokamaks (LOCUST) is designed for computationally scalable modelling of fast-ion dynamics, in the presence of detailed first wall geometries and fine 3D magnetic field structures. It achieves this through multiple levels of single instruction, multiple thread parallelism and by leveraging general-purpose graphics processing units. This enables LOCUST to rapidly track the full-orbit trajectories of kinetic Monte Carlo markers to deliver high-resolution fast-ion distribution functions and plasma-facing component power loads. LOCUST has been tested against the prominent NUBEAM and ASCOT fast-ion codes. All codes were compared for collisional plasmas in both high and low-aspect ratio toroidal geometries, with full-orbit and guiding-centre tracking. LOCUST produces statistically consistent results in line with acceptable theoretical and Monte Carlo uncertainties. Synthetic fast-ion D-α diagnostics produced by LOCUST are also compared to experiment using FIDASIM and show good agreement.Peer reviewe

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study

5-Fluorouracil (5-FU)-based chemotherapy is frequently associated with diarrhoea. We compared two 5-FU-based regimens and the effect of Lactobacillus and fibre supplementation on treatment tolerability. Patients diagnosed with colorectal cancer (n=150) were randomly allocated to receive monthly 5-FU and leucovorin bolus injections (the Mayo regimen) or a bimonthly 5-FU bolus plus continuous infusion (the simplified de Gramont regimen) for 24 weeks as postoperative adjuvant therapy. On the basis of random allocation, the study participants did or did not receive Lactobacillus rhamnosus GG supplementation (1–2 × 1010 per day) and fibre (11 g guar gum per day) during chemotherapy. Patients who received Lactobacillus had less grade 3 or 4 diarrhoea (22 vs 37%, P=0.027), reported less abdominal discomfort, needed less hospital care and had fewer chemotherapy dose reductions due to bowel toxicity. No Lactobacillus-related toxicity was detected. Guar gum supplementation had no influence on chemotherapy tolerability. The simplified de Gramont regimen was associated with fewer grade 3 or 4 adverse effects than the Mayo regimen (45 vs 89%), and with less diarrhoea. We conclude that Lactobacillus GG supplementation is well tolerated and may reduce the frequency of severe diarrhoea and abdominal discomfort related to 5-FU-based chemotherapy

Overview of fast particle experiments in the first MAST Upgrade experimental campaigns

MAST-U is equipped with on-axis and off-axis neutral beam injectors (NBI), and these external sources of super-Alfvénic deuterium fast-ions provide opportunities for studying a wide range of phenomena relevant to the physics of alpha-particles in burning plasmas. The MeV range D-D fusion product ions are also produced but are not confined. Simulations with the ASCOT code show that up to 20% of fast ions produced by NBI can be lost due to charge exchange (CX) with edge neutrals. Dedicated experiments employing low field side (LFS) gas fuelling show a significant drop in the measured neutron fluxes resulting from beam-plasma reactions, providing additional evidence of CX-induced fast-ion losses, similar to the ASCOT findings. Clear evidence of fast-ion redistribution and loss due to sawteeth (ST), fishbones (FB), long-lived modes (LLM), Toroidal Alfvén Eigenmodes (TAE), Edge Localised Modes (ELM) and neoclassical tearing modes (NTM) has been found in measurements with a Neutron Camera (NCU), a scintillator-based Fast-Ion Loss Detector (FILD), a Solid-State Neutral Particle Analyser (SSNPA) and a Fast-Ion Deuterium-α (FIDA) spectrometer. Unprecedented FILD measurements in the range of 1–2 MHz indicate that fast-ion losses can be also induced by the beam ion cyclotron resonance interaction with compressional or global Alfvén eigenmodes (CAEs or GAEs). These results show the wide variety of scenarios and the unique conditions in which fast ions can be studied in MAST-U, under conditions that are relevant for future devices like STEP or ITER

Simulating beam ion charge exchange in MAST-U

Atomic processes were implemented in the orbit-following code ASCOT for simulating fast-ion charge exchange (CX) in magnetically confined fusion plasmas. The model was verified by reaction mean free path estimation and agrees with TRANSP to within 20% on CX losses. ASCOT predicts that 22% of beam power is lost due to CX in a MAST-U target scenario. While plasma heating and current drive are decreased towards the edge, CX is predicted to increase current drive closer to the core. Peak wall power loads of 60-90 kWm-2are estimated on the central poloidal field coils and the vacuum vessel between them.</p

Simulating beam ion charge exchange in MAST-U

Atomic processes were implemented in the orbit-following code ASCOT for simulating fast-ion charge exchange (CX) in magnetically confined fusion plasmas. The model was verified by reaction mean free path estimation and agrees with TRANSP to within 20% on CX losses. ASCOT predicts that 22% of beam power is lost due to CX in a MAST-U target scenario. While plasma heating and current drive are decreased towards the edge, CX is predicted to increase current drive closer to the core. Peak wall power loads of 60-90 kWm-2are estimated on the central poloidal field coils and the vacuum vessel between them.</p

Simulating the impact of charge exchange on beam ions in MAST-U

A model for simulating charge exchange (CX) of fast ions with background atoms in magnetically confined fusion plasmas has been implemented in the ASCOT orbit-following code. The model was verified by comparing simulated reaction mean free paths to analytical values across a range of fusion-relevant parameters. ASCOT was used to simulate beam ions slowing down in the presence of CX reactions in a MAST-U target scenario. ASCOT predicts the CX-induced loss of beam power to be 22%, which agrees to within 15% with the TRANSP prediction. Due to CX, plasma heating and current drive by beam ions are strongly reduced towards the edge. However, an overall lower but noticeable increase of up to 20% in current drive is predicted closer to the core. The simulated deposition of fast CX atoms on the wall is concentrated around the outer midplane, with estimated peak power loads of 70-80 kW m-2 on the central poloidal field coils (P5) and the vacuum vessel wall between them. This analysis demonstrates that ASCOT can be used to simulate fast ions in fusion plasmas where CX reactions play a significant role, e.g. in spherical tokamaks and stellarators.</p