Анализ функционирования свободных экономических зон в России (на примере ОЭЗ «Янтарь» в Калининградской области

Целью работы является анализ функционирования особых экономических зон в России, на примере особой экономической зоны «Янтарь» в Калининградской области. В процессе исследования были изучены теоретические основы свободных экономических зон, так же проводился анализ состояния развития и перспектив свободных экономических зон в России, анализ состояния и эффективности особой экономической зоны «Янтарь» в Калининградской области. Кроме того, проводилось исследование деятельности таможенных органов на территории вышеупомянутой особой экономической зоны. В результате исследования были выявлены проблемы, которые препятствуют эффективной деятельности особой экономической зоны «Янтарь» и деятельности таможенных органов на ее территории.The aim is to analyze the functioning of special economic zones in Russia, in particular by the example of a special economic zone "Amber" in the Kaliningrad region. During the study in the course of research theoretical bases of free economic zones have been studied, also the analysis of a condition of development and prospects of free economic zones in Russia, the analysis of a condition and efficiency of the special economic zone "Amber" in the Kaliningrad region was carried out. In additional, research of activities of customs authorities in the territory of an above-mentioned special economic zone was conducted

Noninvasive in vivo tracking of mesenchymal stem cells and evaluation of cell therapeutic effects in a murine model using a clinical 3.0 T MRI

Cardiac cell therapy with mesenchymal stem cells (MSCs) represents a promising treatment approach for endstage heart failure. However, little is known about the underlying mechanisms and the fate of the transplanted cells. The objective of the presented work is to determine the feasibility of magnetic resonance imaging (MRI) and in vivo monitoring after transplantation into infarcted mouse hearts using a clinical 3.0 T MRI device. The labeling procedure of bone marrow-derived MSCs with micron-sized paramagnetic iron oxide particles (MPIOs) did not affect the viability of the cells and their cell type-defining properties when compared to unlabeled cells. Using a clinical 3.0 T MRI scanner equipped with a dedicated small animal solenoid coil, 105 labeled MSCs could be detected and localized in the mouse hearts for up to 4 weeks after intramyocardial transplantation. Weekly ECG-gated scans using T1-weighted sequences were performed, and left ventricular function was assessed. Histological analysis of hearts confirmed the survival of labeled MSCs in the target area up to 4 weeks after transplantation. In conclusion, in vivo tracking of labeled MSCs using a clinical 3.0 T MRI scanner is feasible. In combination with assessment of heart function, this technology allows the monitoring of the therapeutic efficacy of regenerative therapies in a small animal model. </jats:p

Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass

<p>Abstract</p> <p>Background</p> <p>Hemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass (CPB) and mild hypothermia.</p> <p>Methods</p> <p>Three indices of left ventricular myocardial contractile function (dP/dt, (dP/dt)/P, and wall thickening) were studied up to 6 hours after CPB in neonatal piglets (CPB group; n = 4). The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB (non-CPB group; n = 3).</p> <p>Results</p> <p>Left ventricular dP/dt_maxand (dP/dt_max)/P remained stable in CPB group, while dP/dt_maxdecreased in non-CPB group 5 hours postoperatively (1761 ± 205 mmHg/s at baseline vs. 1170 ± 205 mmHg/s after 5 h; p < 0.05). However, with regard to dP/dt_maxand (dP/dt_max)/P there were no statistically significant differences between the two groups. Comparably, although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant.</p> <p>Conclusions</p> <p>The myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility.</p

Автоматизированная система управления регулятором давления газа на газораспределительной станции «Вертикос».

Доведение технического состояния ГРС до уровня, отвечающего современным требованиям по промышленной безопасности. Достижение высоких технико-экономических показателей работы за счет автоматизированного поддержания наиболее рационального режима работы технологического оборудования.Bringing the technical condition of the GDS to a level that meets modern requirements for industrial safety. Achievement of high technical and economic performance due to the automated maintenance of the most rational mode of operation of technological equipment