2 research outputs found
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma.
non-edited manuscriptThe first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors.
METHODS:
Invited patients signed the informed consent form, and interviews were conducted in order to obtain information about sociodemographic and lifestyle behavior. During endoscopy, esophageal biopsies were collected from case and controls. Multiplex polymerase chain reaction genotyping was conducted on endoscopic biopsies to identify HPV types and HPV-16 was further evaluated by specific PCR real time.
RESULTS:
Among 87 cases, 12 (13.8%) had tumors harboring high risk HPV DNA and among 87 controls, 12 (13.8%) had high risk HPV DNA (OR:1.025 [CI:0.405:2.592]). Variables regarding consumption of alcohol and use of tobacco continued to characterize risk factors even after adjustments by presence or absence of high risk HPV.
CONCLUSION:
HPV was demonstrated to be frequently and similarly associated to normal and malignant esophageal tissues, but not as an independent risk factor to esophageal cancer.
IMPACT:
To contribute to the Brazilian population data on this subject, which is still contradictory.CNPq Universal for providing supplies to the largest study, of which this study is a part of, entitled “The role of human papillomavirus (HPV) as the etiologic agent of esophageal cancer.
A cross-sectional study, case-control and longitudinal at Barretos Cancer Hospital”; (Grant number 482666/2012-9 to ALF); INCT HPV [Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP) [Grant number 08/57889-1 to LLV]; Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq) (Grant number 573799/2008-3 to LLV)]info:eu-repo/semantics/acceptedVersio
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma
Background. The first publication that
associated Human Papillomavirus (HPV) infection and
esophageal cancer was published in 1982. However, data
are still contradictory and require further investigation.
The aim of this study was to identify high risk HPV
DNA in esophageal tissue of patients with and without
esophageal squamous cell carcinoma (ESCC) and
correlate HPV presence with classical risk factors.
Methods. Invited patients signed the informed consent
form, and interviews were conducted in order to obtain
information about sociodemographic and lifestyle
behavior. During endoscopy, esophageal biopsies were
collected from case and controls. Multiplex polymerase
chain reaction genotyping was conducted on endoscopic
biopsies to identify HPV types and HPV-16 was further
evaluated by specific PCR real time. Results. Among 87
cases, 12 (13.8%) had tumors harboring high risk HPV
DNA and among 87 controls, 12 (13.8%) had high risk
HPV DNA (OR:1.025 [CI:0.405:2.592]). Variables
regarding consumption of alcohol and use of tobacco
continued to characterize risk factors even after
adjustments by presence or absence of high risk HPV.
Conclusion. HPV was demonstrated to be frequently and
similarly associated to normal and malignant esophageal
tissues, but not as an independent risk factor to
esophageal cancer. Impact. To contribute to the Brazilian
population data on this subject, which is still
contradictory