SNW1 is a spliceosomal component and transcriptional co-regulator that provides a modulatory coupling of transcription initiation and splicing. SNW1 appears to be an essential cancer cell survival factor by co-transcriptionally regulating mRNA splicing of proteins involved in cell cycle checkpoints... a co-regulator, SNW1 is shown to attune the activity of a number of transcription factors, including nuclear hormone receptors as well as CBF1, Smad2/3, and MyoD by modulating a transition step be