The Importance of Clinical and Biochemical Markers in the Diagnosis of Disorders of the Psychomotor and Physical Development of Children who Underwent Perinatal CNS Lesions

The purpose of this study was to evaluate the blood level of neurotrophic factors (S100 protein, nerve growth factor, L- homocysteine and angiotensin II) in the diagnosis of disorders of the psychomotor and physical development of children who underwent perinatal CNS lesions. A comprehensive approach to assessing the blood levels of neurotrophic factors, along with methods of neuroimaging in children in the first 6 months of the postnatal period, allows identification of the total result of multidirectional degenerative-reparative processes in the neurovascular components of CNS and construction of the diagnostically significant criteria of the severity of neuropathology, which determines the physical development of children in the first year of life

Relationship Between Indices of Oxidative Stress, Endothelial Dysfunction and Chaperone Activity and the Severity of Coronary Atherosclerosis

The aim of this research was to study the relationship between the indices of oxidative stress, endothelial dysfunction and chaperone activity of proteins with the severity of coronary atherosclerosis. In patients with coronary heart disease, we found gender-related differences in the severity of coronary atherosclerosis. Significant differences in the indices of oxidative stress, endothelial dysfunction and chaperone activity were revealed depending on the severity of coronary atherosclerosis and the type of atherosclerotic lesion. The determination of studied parameters can serve as a good indicator of the severity of coronary atherosclerosis

Serum Level of Homocysteine and Perinatal CNS Lesions in Infants

This study reports an assessment of adaptive possibilities of the central nervous system (CNS) in infants. The study shows how the homocysteine level depends on the severity of neurological deficit (ND) in infants, and how the serum homocysteine level changes during the various treatment regimens

Role of Nerve Growth Factor in Assessing the Severity of Clinical Manifestations and Outcomes of Perinatal CNS Lesions in Infants

The purpose of our research was to analyze the association between the serum beta-NGF level and the severity of neurological deficit (ND) in children in the first year of life. Our results suggest a possible functional link between the low level of NGF and the development of severe ND. The obtained results allow us to consider the serum beta-NGF level as a useful marker of the ND severity in young children