3 research outputs found
The evaluation of mechanical properties of animal tendons after corticosteroid therapy.
Get PDFThe purpose of the study was to examine the effect of systemic glucocorticosteroids administration on mechanical properties of animal tendons. Twenty female Wistar rats were divided into two groups and those that formed experimental group were subjected activity of hydrocortisone given to the peritoneum. Mechanical tests were performed. Hydrocortisone administration caused reduction of force value and the increase of strain, also the value of elasticity module was significantly smaller comparing to the control group. The results of biomechanical tests suggested that glucocorticoids produce less stiffness tendon, which fails in maximum point of load. This study revealed that systemic hydrocortisone administration changes significantly mechanical properties of tendons, which may cause frequent failure of the tendon
Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration
Get PDFCaffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been<br />shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to<br />assess the influence of caffeine on the development of bone tissue, with particular reference to elemental<br />bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females<br />were randomly divided into an experimental and a control group. The experimental group was<br />given caffeine orally in 30 mg/day doses from the 8th to the 21st day of pregnancy, while the control group<br />was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the<br />basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted.<br />For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental<br />group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the<br />development of variants in the experimental group was statistically higher. In the experimental group,<br />a significant decrease in the calcium level, as well as an increase in the potassium level, was observed.<br />The X-ray microprobe’s undoubted advantage is that is offers a quick qualitative and quantitative analysis<br />of the elemental composition of the examined samples. Employing this new technique may furnish us<br />with new capabilities when investigating the essence of the pathology process.<br>Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been<br />shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to<br />assess the influence of caffeine on the development of bone tissue, with particular reference to elemental<br />bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females<br />were randomly divided into an experimental and a control group. The experimental group was<br />given caffeine orally in 30 mg/day doses from the 8th to the 21st day of pregnancy, while the control group<br />was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the<br />basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted.<br />For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental<br />group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the<br />development of variants in the experimental group was statistically higher. In the experimental group,<br />a significant decrease in the calcium level, as well as an increase in the potassium level, was observed.<br />The X-ray microprobe’s undoubted advantage is that is offers a quick qualitative and quantitative analysis<br />of the elemental composition of the examined samples. Employing this new technique may furnish us<br />with new capabilities when investigating the essence of the pathology process
The evaluation of mechanical properties of animal tendons after corticosteroid therapy.
No full textThe purpose of the study was to examine the effect of systemic glucocorticosteroids administration on mechanical properties of animal tendons. Twenty female Wistar rats were divided into two groups and those that formed experimental group were subjected activity of hydrocortisone given to the peritoneum. Mechanical tests were performed. Hydrocortisone administration caused reduction of force value and the increase of strain, also the value of elasticity module was significantly smaller comparing to the control group. The results of biomechanical tests suggested that glucocorticoids produce less stiffness tendon, which fails in maximum point of load. This study revealed that systemic hydrocortisone administration changes significantly mechanical properties of tendons, which may cause frequent failure of the tendon
