Effect of Pyrus communis (Common Pear) Seeds on Selected Parameters of Liver Function in Rats Treated with Cadmium

The study investigated possible hepatoprotective potentials of Pyrus communis (PC) seeds in rats treated with cadmium. Twenty Wistar rats weighing 150 g - 180 g were divided into 4 groups (A, B, C and D) of 5 rats each. Group A received distilled water only. 5mg/kg bwt cadmium was given to group B orally while group C were pre-administered with 500mg/kg bwt PC extract orally. Group D received 500mg/kg bwt PC. After two weeks of treatment, serum and liver homogenate were evaluated for haptoglobin, (Hp) total protein (TP), albumin, alanine transaminase, (ALT) and aspartate transaminase, (AST). The results showed significant (p<0.05) reduction in liver and serum Hp concentrations in rats treated with cadmium. There was also significant (p<0.05) decrease in liver TP, ALT and AST levels and significant (p<0.05) increase in serum TP, ALT and AST levels in rats treated with cadmium. However, treatment with PC restored Hp, TP, ALT and AST levels back to near normal. We concluded that 5mg/kg bwt cadmium caused liver damage and depressed Hp synthesis, and PC protected the liver

Demographic transition, demographic dividend and economic growth in Nigeria

Abstract Changes in age structure that results from demographic transition have economic consequences. This paper identifies the period of potential window of opportunity or demographic dividends created by Nigeria’s demographic transition. This is done by simulating the period of the demographic window of opportunity in Nigeria. In a simulation covering 1950 – 2050 our results reveal that Nigeria entered the window of opportunity in 2003 and will last beyond year 2050. The highest benefit will accrue in years 2032 and 2033 when the dividend can account for more than 10% of the growth of GDP per capita even if the current performance scenario continues to exist. However, the paper notes that the demographic dividend is not automatically realized and Nigeria needs to embark on strategies that will develop her human capital and position her towards not only capturing the first dividend but the second dividend as well.Keywords: demographic transition; demographic dividends;national transfer accounts (NTA); economic lifecycle;economic support ratioRésumé Les changements dans la structure d'âge qui provient de la transition démographique ont des conséquences économiques. Ce papier identifie la période de fenêtre potentielle d'opportunité ou de dividendes démographiques créés par la transition démographique du Nigeria. C'est fait en simulant la période de la fenêtre démographique d'opportunité au Nigeria. Dans une simulation couvrant 1950 – 2050. Nos résultats révèlent que le Nigeria est entré dans la fenêtre d'opportunité en 2003 et durera au-delà de l'année 2050. Le plus haut avantage s'accumulera au cours des années 2032 et 2033 où le dividende peut représenter plus de 10 % de la croissance de PIB par habitant même si le scénario de performance actuel continue à exister. Pourtant, le papier note que le dividende démographique n'est pas automatiquement réalisé et le Nigeria doit entreprendre des stratégies qui développeront sa capitale humaine et la placeront vers le fait de non capturer seulement le premier dividende, mais le deuxième dividende aussi.Mots clé: la transition démographique, les dividendes démographiques, les comptes de transfert nationaux (NTA), life cyclé économique, le rapport de soutien économiqu

Qualitative study of barriers to cervical cancer screening among Nigerian women.

OBJECTIVES: To explore the barriers to cervical cancer screening, focusing on religious and cultural factors, in order to inform group-specific interventions that may improve uptake of cervical cancer screening programmes. DESIGN: We conducted four focus group discussions among Muslim and Christian women in Nigeria. SETTING: Discussions were conducted in two hospitals, one in the South West and the other in the North Central region of Nigeria. PARTICIPANTS: 27 Christian and 22 Muslim women over the age of 18, with no diagnosis of cancer. RESULTS: Most participants in the focus group discussions had heard about cervical cancer except Muslim women in the South Western region who had never heard about cervical cancer. Participants believed that wizardry, multiple sexual partners and inserting herbs into the vagina cause cervical cancer. Only one participant knew about the human papillomavirus. Among the Christian women, the majority of respondents had heard about cervical cancer screening and believed that it could be used to prevent cervical cancer. Participants mentioned religious and cultural obligations of modesty, gender of healthcare providers, fear of disclosure of results, fear of nosocomial infections, lack of awareness, discrimination at hospitals, and need for spousal approval as barriers to uptake of screening. These barriers varied by religion across the geographical regions. CONCLUSIONS: Barriers to cervical cancer screening vary by religious affiliations. Interventions to increase cervical cancer awareness and screening uptake in multicultural and multireligious communities need to take into consideration the varying cultural and religious beliefs in order to design and implement effective cervical cancer screening intervention programmes

Age-specific prevalence of human papilloma virus infection among Nigerian women

Background: Inconsistent trends in HPV prevalence by age have been described in Africa. We examined the age prevalence pattern and distribution of 37 HPV-DNA types among urban Nigerian women. Methods: The study population was a sample of 278 women who presented to cervical cancer screening programs in Abuja, Nigeria, between April and August 2012. Using a nurse administered questionnaire, information on demographic characteristics and risk factors of cervical cancer was collected and samples of cervical exfoliated cells were obtained from all participants. Roche Linear Array HPV Genotyping Test® was used to characterize prevalent HPV and log-binomial regression models were used to examine the association between potential correlates and the prevalence of HPV infection. Results: The mean age (SD) of the women enrolled was 38 (8) years. The overall prevalence of HPV was 37%. HPV 35 was the most prevalent HPV type in the study population. Among women age ≤ 30 years, 52% had HPV infection compared to 23% of those women who were older than 45 years (p = 0.006). We observed a significant linear association between age and the prevalence of HPV infections. The prevalence ratio (PR) and 95% confidence interval (CI) was 2.26 (1.17, 4.34) for any HPV infection, 3.83 (1.23, 11.94) for Group 1 HPV (definite carcinogens), and 2.19 (0.99, 4.84) for Group 2a or 2b HPV (probable or possible carcinogens) types, among women aged 18–30 years, compared to women who were older than 45 years. Conclusion: The prevalence of HPV infection was highest among younger women and decreased steadily with age among this population of urban Nigerian women

Cervical cancer risk factors among HIV-infected Nigerian women

Background: Cervical cancer is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Cervical cancer is an AIDS-defining cancer; however, HIV only marginally increases the risk of cervical pre-cancer and cancer. In this study, we examine the risk factors for cervical pre-cancer and cancer among HIV-positive women screened for cervical cancer at two medical institutions in Abuja, Nigeria. Methods: A total of 2,501 HIV-positive women participating in the cervical cancer screen-and-treat program in Abuja, Nigeria consented to this study and provided socio-demographic and clinical information. Log-binomial models were used to calculate relative risk (RR) and 95% confidence intervals (95%CI) for the risk factors of cervical pre-cancer and cancer. Results: There was a 6% prevalence of cervical pre-cancer and cancer in the study population of HIV-positive women. The risk of screening positivity or invasive cancer diagnosis reduced with increasing age, with women aged 40 years and older having the lowest risk (RR=0.4; 95%CI=0.2–0.7). Women with a CD4 count of 650 per mm3 or more also had lower risk of screening positivity or invasive cancer diagnosis (RR=0.3, 95%CI=0.2–0.6). Other factors such as having had 5 or more abortions (RR=1.8, 95%CI=1.0–3.6) and the presence of other vaginal wall abnormalities (RR=1.9, 95%CI=1.3–2.8) were associated with screening positivity or invasive cancer diagnosis. Conclusion: The prevalence of screening positive lesions or cervical cancer was lower than most previous reports from Africa. HIV-positive Nigerian women were at a marginally increased risk of cervical pre-cancer and cancer. These findings highlight the need for more epidemiological studies of cervical cancer and pre-cancerous lesions among HIV-positive women in Africa and an improved understanding of incidence and risk factors

Evaluation of neuronal inflammation and oxidative DNA damage in different haptoglobin phenotypes of Nigerian type-2 diabetes mellitus population

Background: Oxidative stress is a major factor in the pathogenesis and progression of the clinical condition type 2 Diabetes Mellitus (DM) related to adverse biochemical/molecular interactions. Aim and Objectives: To determine whether haptoglobin phenotypes predispose DM patients to vascular complications and neuronal damage. Material and Methods: A total of 74 subjects were assessed out of which 31 had treated and untreated diabetes complicated with hypertension, 26 had treated and untreated uncomplicated DM and 17 were apparently healthy subjects who served as controls. Body Mass Index (BMI), Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP), serum Glucose (GLU), protein S100B and 8-Hydroxy-2-deoxyguanosine (8-OHdG) were determined in all subjects alongside the characterization of Haptoglobin (Hp) phenotypes. Results: BMI, SBP, DBP, GLU, protein S100B and 8-OHdG in treated and untreated complicated and uncomplicated DM patients were higher when compared to controls (p < 0.05). Hp 2 allele (Hp 2-1 and Hp2-2) was seen to be associated with poor glucose control, higher blood pressure and increased neuronal damage in both complicated and uncomplicated DM. It was also seen that the possession of Hp 2 gene was associated with a lower response to treatment. Conclusion: The Hp 2 allele could be a predisposing factor in developing diabetes related complications like hypertension and neuronal damage

HIV associated high-risk HPV infection among Nigerian women

Background: In developed countries, the incidence of cervical cancer has remained stable in HIV+ women but the prevalence and multiplicity of high-risk HPV (hrHPV) infection, a necessary cause of cervical cancer, appears different comparing HIV+ to HIV- women. Little is known about HIV and HPV co-infection in Africa. Methods: We enrolled women presenting at our cervical cancer screening program in Abuja, Nigeria between April and August 2012, and collected information on demographic characteristics, risk factors of HPV infection and samples of exfoliated cervical cells. We used Roche Linear Array HPV Genotyping Test® to characterize prevalent HPV and logistic regression models to estimate the association between HIV and the risk of hrHPV infection. Results: There were 278 participants, 54% (151) were HIV+, 40% (111) were HIV-, and 6% (16) had unknown HIV status. Of these, data from 149 HIV+ and 108 HIV- women were available for analysis. The mean ages (±SD) were 37.6 (±7.7) years for HIV+ and 36.6 (±7.9) years for HIV- women (p-value = 0.34). Among the HIV+ women, HPV35 (8.7%) and HPV56 (7.4%) were the most prevalent hrHPV, while HPV52 and HPV68 (2.8%, each) were the most prevalent hrHPV types among HIV- women. The multivariate prevalence ratio for any hrHPV and multiple hrHPV infections were 4.18 (95% CI 2.05 – 8.49, p-value <0.0001) and 6.6 (95% CI 1.49 – 29.64, p-value 0.01) respectively, comparing HIV + to HIV- women, adjusted for age, and educational level. Conclusions: HIV infection was associated with increased risk of any HPV, hrHPV and multiple HPV infections. Oncogenic HPV types 35, 52, 56 and 68 may be more important risk factors for cervical pre-cancer and cancer among women in Africa. Polyvalent hrHPV vaccines meant for African populations should protect against other hrHPV types, in addition to 16 and 18

Influence of Spirituality and Modesty on Acceptance of Self-Sampling for Cervical Cancer Screening.

INTRODUCTION: Whereas systematic screening programs have reduced the incidence of cervical cancer in developed countries, the incidence remains high in developing countries. Among several barriers to uptake of cervical cancer screening, the roles of religious and cultural factors such as modesty have been poorly studied. Knowledge about these factors is important because of the potential to overcome them using strategies such as self-collection of cervico-vaginal samples. In this study we evaluate the influence of spirituality and modesty on the acceptance of self-sampling for cervical cancer screening. METHODOLOGY: We enrolled 600 participants in Nigeria between August and October 2014 and collected information on spirituality and modesty using two scales. We used principal component analysis to extract scores for spirituality and modesty and logistic regression models to evaluate the association between spirituality, modesty and preference for self-sampling. All analyses were performed using STATA 12 (Stata Corporation, College Station, Texas, USA). RESULTS: Some 581 (97%) women had complete data for analysis. Most (69%) were married, 50% were Christian and 44% were from the south western part of Nigeria. Overall, 19% (110/581) of the women preferred self-sampling to being sampled by a health care provider. Adjusting for age and socioeconomic status, spirituality, religious affiliation and geographic location were significantly associated with preference for self-sampling, while modesty was not significantly associated. The multivariable OR (95% CI, p-value) for association with self-sampling were 0.88 (0.78-0.99, 0.03) for spirituality, 1.69 (1.09-2.64, 0.02) for religious affiliation and 0.96 (0.86-1.08, 0.51) for modesty. CONCLUSION: Our results show the importance of taking cultural and religious beliefs and practices into consideration in planning health interventions like cervical cancer screening. To succeed, public health interventions and the education to promote it must be related to the target population and its preferences

Recurrence of cervical intraepithelial lesions after thermo-coagulation in HIV-positive and HIV-negative Nigerian women

Background: The burden of cervical cancer remains huge globally, more so in sub-Saharan Africa. Effectiveness of screening, rates of recurrence following treatment and factors driving these in Africans have not been sufficiently studied. The purpose of this study therefore was to investigate factors associated with recurrence of cervical intraepithelial lesions following thermo-coagulation in HIV-positive and HIV-negative Nigerian women using Visual Inspection with Acetic Acid (VIA) or Lugol’s Iodine (VILI) for diagnosis. Methods: A retrospective cohort study was conducted, recruiting participants from the cervical cancer “see and treat” program of IHVN. Data from 6 sites collected over a 4-year period was used. Inclusion criteria were: age ≥18 years, baseline HIV status known, VIA or VILI positive and thermo-coagulation done. Logistic regression was performed to examine the proportion of women with recurrence and to examine factors associated with recurrence. Results: Out of 177 women included in study, 67.8 % (120/177) were HIV-positive and 32.2 % (57/177) were HIV-negative. Recurrence occurred in 16.4 % (29/177) of participants; this was 18.3 % (22/120) in HIV-positive women compared to 12.3 % (7/57) in HIV-negative women but this difference was not statistically significant (p-value 0.31). Women aged ≥30 years were much less likely to develop recurrence, adjusted OR = 0.34 (95 % CI = 0.13, 0.92). Among HIV-positive women, CD4 count <200cells/mm3 was associated with recurrence, adjusted OR = 5.47 (95 % CI = 1.24, 24.18). Conclusion: Recurrence of VIA or VILI positive lesions after thermo-coagulation occurs in a significant proportion of women. HIV-positive women with low CD4 counts are at increased risk of recurrent lesions and may be related to immunosuppression