Linfoma malt primario de la lengua

Los linfomas derivados de los tejidos linfoides asociados a las mucosas (MALT) primarios de la lengua son infrecuentes. Se documenta el caso de una paciente de 80 años de edad, con un tumor en el dorso de la lengua filiado histológicamente como linfoma extranodal de células B. Se sugiere como posible origen del linfoma un proceso reactivo de origen desconocido, al presentar las glándulas salivales menores adyacentes al tumor un cuadro compatible con una sialadenitis mioepitelial.Primitive malignant lymphoma mucosa associated lymphoid tissue (MALT) on the tongue are rare entities. We report here a case of an old woman (80 years old) with a tumor in the dorsum of the tongue, which was histologically diagnosed as an extra-nodal marginal B cell lymphoma. An inflammatory reaction resembling myoepithelial sialoadenitis was observed in the minor salivary glands adjacent at the tumour, suggesting a possible derivation of the lymphoma from a previous reactive process of unknown origin

Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis

Adverse effects associated with the use of bisphosphonates are infrequent and consist of pyrexia, renal function impairment, and hypocalcemia. Bisphosphonates-associated osteonecrosis of the jaws is an uncommon but potentially serious complication of intravenous bisphosphonate therapy in cancer patients. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alendronate, is uncertain and warrants careful monitoring. Oral bisphosphonates-associated osteonecrosis can occur in patients with rheumatoid arthritis. We report a case of mandibular osteonecrosis in a patient who received alendronate for 3.8 years. The pathology improved after bisphosphonate therapy discontinuation and sequestrectomy. To our knowledge there are only three cases published in the literature relating bisphosphonates-associated osteonecrosis of the jaws in patients with rheumatoid arthritis. All the cases published, including our case, have reported association between methotrexate, prednisone and alendronate sodium (Fosamax®) therapy. Corticosteroid therapy and dental surgery could increase the risk of developing bisphosphonates-associated osteonecrosis of the jaws in these patients

Odontoma intraóseo erupcionado: una infrecuente patología

Objetivos: Los odontomas que afectan a los tejidos blandos son muy infrecuentes, pudiendo presentarse bajo dos formas clinicas: odontoma periférico y odontoma erupcionado. Se documenta un caso de odontoma erupcionado con el objetivo de discutir entre ambas formas de presentación clínica de esta patología. Diseño del estudio: Estudio de caso. Resultados: Se presenta el caso de un varón con una masa dura localizada en la región posterior del reborde alveolar izquierdo del maxilar superior, de un año de evolución y lento crecimiento. La ortopantomografía mostró la presencia de una tumoración radiodensa en la región posterior del maxilar izquierdo. El estudio histológico de la pieza operatoria fue de odontoma complejo. Conclusiones: Hasta el momento se han documentado 11 casos de odontoma erupcionado en la literatura. A diferencia del odontoma periférico, el odontoma erupcionado suele ser del tipo complejo, afectando a pacientes de mayor edad.Objectives: Odontoma arising in the extraosseous soft tissue is extremely uncommon. Two forms of odontoma are presently recognized: peripheral odontoma and erupted odontoma. We report an erupted odontoma arising in the posterior maxilla, and discuss the main differences between both forms of clinical presentation. Study design: Case study. Results: A 23-year-old man presented with a firm gingival mass on the left posterior maxilla, that had gradually enlarged over one year. Orthopantomography showed a dense radiopaque mass occupying the posterior portion of the left maxilla. The pathology was reported as complex odontoma. Conclusions: This is the eleventh reported case of erupted odontoma. Unlike peripheral odontoma, erupted odontoma is generally a complex odontoma, and affects older patients

Influence of the teaching program on the learning in knowledge and practice of osteonecrosis of the jaws produced by antireasorptives in dental students of the Principality of Asturias (Spain)

This study aims to evaluate the influence of changes in the teaching contents on medication-related osteonecrosis of the jaw may have on the knowledge and the capacity for practical case resolution about this pathology. A cross-sectional descriptive study was conducted through a survey divided into four sections: degree of means of knowledge acquisition, habitual practice and ability to solve clinical cases. The total number of respondents (n = 225) was divided into two groups: Group A (Year 2015-2016) and Group B (Year 2016-2017). The students in Group B received more teaching content on the subject than group A. A total of 175 survey responses were collected. The internet was the preferred tool for continuing education in both groups. The best known bisphosphonates (BPs) were Alendronate (Fosamax®: 56.9% Group A, 67.5% Group B) and Zoledronic Acid (Zometa®: 56.9% Group A, 51.8% Group B). A low percentage of students (37.9% Group A, 43.4% Group B) acknowledged the existence of other drugs that could also cause osteonecrosis of the jaws. Regarding the correct resolution of practical cases, the respondents of Group B reached a significantly higher score (5.67) than the score observed in Group A (4.04). Training on medication-related osteonecrosis among dental students is susceptible to improvement. Introducing minor changes in the teachings allows this goal to be successfully achieved

Valor pronóstico de la apoptosis y de los genes relacionados con la misma: p-53, bcl-2 y bax en el carcinoma de células escamosas de la cavidad oral

Objetivos 1,- estudiar la relación existente entre la apoptosis y tres genes relacionados con la misma: p-53, bcl-2 y bax. 2,- evaluar la relación entre la apoptosis, los genes p-53, bcl-2 y bax y las variables clínicas e histológicas de los carcinomas de células escamosas de la boca. 3,- estudiar la supervivencia de los pacientes con carcinoma escamoso de la boca en función de las variables clínicas, histológicas e inmunohistoquímicas investigadas. Diseño se ha realizado un estudio analítico observacional de carácter prospectivo. La muestra estaba constituida por 91 enfermos diagnósticados e intervenidos de carcinoma escamoso oral. Las variables clínicas e histológicas investigadas fueron: edad, sexo, localización, tamaño tumoral, grado de afectación granglionar, estadio tnm, estado del paciente al final del estudio, y grado de diferenciación. El seguimiento mínimo de los casos fue de 6 meses. Para el análisis inmunohistoquímico se utilizaron anticuerpos para la p-53, bcl-2 y bax mediante el método en visión y/o lsab. Para el estudio de las apoptosis se utilizó el procedimiento túnel, cuantificándose dos variables; apoptosis e índice apoptótico. En el análisis inferencial se emplearon pruebas paramétricas y no paramétricas. Se consideraron diferencias significativas aquellas en las que el valor de p<0,05. El estudio de la supervivencia se llevó a cabo con los métodos Kaplan-Meier, actuarial, y regresión de riesgos proporcionados de cox. Resultados la edad media de los enfermos fue de 60 años. El 76,9% de los pacientes eran varones. Lengua y suelo de la boca fueron las localizaciones de mayor incidencia. La mayor parte de los casos eran t2 ó t4, sin afectación ganglionar en el momento del tratamiento. La mayor parte de los pacientes (51 enfermos) se filiaron en los estadios tnm iii y iva [...

Effects of Vape Use on Oral Health: A Review of the Literature

Background and Objectives: The widespread use of tobacco has evolved with the popularity of vapes, especially among young people, despite the lack of clarity in warnings about their risks. Studies indicate the need for more effective communication about the oral risks of vaping. In addition to systemic, respiratory, and cardiovascular effects, vaping is associated with an increased risk of gingivitis and periodontal disease as well as reduced antioxidant capacity of saliva. The objectives of this narrative review are to summarize the existing information in the literature on the effects of vaping at the oral level and to bring together knowledge about the mechanism of action of vaping in oral tissues. Materials and Methods: In the present study, articles were searched in PubMed, Elsevier Scopus, and Web of Science using the keywords “oral health”, “vaping”, and “vape”. Studies published in the last 6 years that addressed the effects of oral vaping were selected, including comparisons among vape users, smokers, and non-smokers. Repeated articles, prior to 2017 and in languages other than English, were excluded. Two review authors (A.M.I and M.F.E.M) independently selected the papers based on titles and abstracts and conducted a full review of the remaining papers. In cases of disagreement, a third reviewer was used. Results: A total of 113 results were obtained, distributed as 16 from PubMed, 35 from Web of Science, and 62 from Elsevier Scopus. After removing duplicates, 67 articles were filtered by reviewing titles and abstracts, and finally, 22 articles were selected for comprehensive reading. Subsequently, eight of these articles were chosen for qualitative synthesis and are presented in standardized tables. The sample size of all included studies was composed of 31,647 participants, (14,477 male and 17,170 female) with a mean of 35.016 ± 7.57 years of age. Conclusions: This review indicates that the use of vapes is associated with an increased risk of periodontitis and caries. Although users experience more oral problems than non-smokers, these are less severe than those of traditional smokers. The widespread prevalence, especially among young people, highlights the urgency of awareness campaigns to warn of risks and understand potential harm

Medicina basada en la evidencia (MBE): ventajas

Abstract: Evidence Based Medicine (EBM) is defined as a process whose objective is the selection of the best scientific arguments for the resolution of problems in the medical practice. Phylosophically, it is a new paradigm that has been extended to all the sanitary professions (Evidence Based Surgery, Evidence Based Dentistry, etc.), sustained by the technological advances. Although their advantages are evident, also there have been recognized limitations, specially concerning the surgical practice. At the present work the bases and the main advantages of the EBM are checked.Resumen: La Medicina basada en la Evidencia (MBE) se define como un proceso cuyo objetivo es la selección de los mejores argumentos científicos para la resolución de los problemas que la práctica médica cotidiana plantea. Filosóficamente es un nuevo paradigma (verificacionista), que se ha extendido a todas las profesiones sanitarias (Cirugía Basada en la Evidencia, Odontología Basada en la Evidencia, etc.), soportado por los avances tecnológicos. Aunque sus ventajas son evidentes, también se han reconocido limitaciones, especialmente en lo concerniente a la práctica quirúrgica. En el presente trabajo se revisan los fundamentos y principales ventajas de la MBE