ELECTRODIALYSIS PHENOMENA OF AQUEOUS SOLUTIONS CONTAINING PHOSPHORIC ACID AND METAL IONS

The electrodialysis phenomena of aqueous solutions containing phosphoric acid, Al and Mo ions were investigated in this study. A feasibility study of electrodialysis for treatment of waste phosphoric acid containing metal ions was also carried out. The desalination percentage of various ions shows different values through a kind of ion-exchange membrane. The voltage, solution concentration and feed temperature mainly affect electrodialysis of phosphoric acid containing Al and Mo ions. Higher voltage and feed temperature are beneficial for desalination of Al and Mo ions. At least 30% of Al ions and 7% of Mo ions can be removed from the phosphoric acid by using CMX/ AMX, CM1/ AM1 and CMX-SB/ ACS ion-exchange membranes. The electrodialysis process seems to be a promising one for use in treatment of waste phosphoric acid containing Al and Mo ions.This work was supported by the MEXT, Grant-in-Aid for Scientific Research (A)(1),(17206091).CHEMICAL, ENERGY AND ENVIRONMENTAL ENGINEERING, 50th anniversary editio

3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus

Brazilian green propolis water extract (PWE) and its chemical components, caffeoylquinic acids, such as 3,4-dicaffeoylquinic acid (3,4-diCQA), act against the influenza A virus (IAV) without influencing the viral components. Here, we evaluated the anti-IAV activities of these compounds in vivo. PWE or PEE (Brazilian green propolis ethanol extract) at a dose of 200 mg/kg was orally administered to Balb/c mice that had been inoculated with IAV strain A/WSN/33. The lifetimes of the PWE-treated mice were significantly extended compared to the untreated mice. Moreover, oral administration of 3,4-diCQA, a constituent of PWE, at a dose of 50 mg/kg had a stronger effect than PWE itself. We found that the amount of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA in the mice that were administered 3,4-diCQA was significantly increased compared to the control group, while H1N1 hemagglutinin (HA) mRNA was slightly decreased. These data indicate that PWE, PEE or 3,4-diCQA possesses a novel and unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL

Clinicopathological analysis of recurrence patterns and prognostic factors for survival after hepatectomy for colorectal liver metastasis

<p>Abstract</p> <p>Background</p> <p>Hepatectomy is recommended as the most effective therapy for liver metastasis from colorectal cancer (CRCLM). It is crucial to elucidate the prognostic clinicopathological factors.</p> <p>Methods</p> <p>Eighty-three patients undergoing initial hepatectomy for CRCLM were retrospectively analyzed with respect to characteristics of primary colorectal and metastatic hepatic tumors, operation details and prognosis.</p> <p>Results</p> <p>The overall 5-year survival rate after initial hepatectomy for CRCLM was 57.5%, and the median survival time was 25 months. Univariate analysis clarified that the significant prognostic factors for poor survival were depth of primary colorectal cancer (≥ serosal invasion), hepatic resection margin (< 5 mm), presence of portal vein invasion of CRCLM, and the presence of intra- and extrahepatic recurrence. Multivariate analysis indicated the presence of intra- and extrahepatic recurrence as independent predictive factors for poor prognosis. Risk factors for intrahepatic recurrence were resection margin (< 5 mm) of CRCLM, while no risk factors for extrahepatic recurrence were noted. In the subgroup with synchronous CRCLM, the combination of surgery and adjuvant chemotherapy controlled intrahepatic recurrence and improved the prognosis significantly.</p> <p>Conclusions</p> <p>Optimal surgical strategies in conjunction with effective chemotherapeutic regimens need to be established in patients with risk factors for recurrence and poor outcomes as listed above.</p

解糖系酵素ホスホグリセリン酸ムターゼの恒常的強発現はマウスにおいて心臓エネルギー代謝を修飾しストレス抵抗性を低下させる

京都大学0048新制・課程博士博士(医学)甲第17977号医博第3841号新制||医||1001(附属図書館)80821京都大学大学院医学研究科医学専攻(主査)教授 岩井 一宏, 教授 稲垣 暢也, 教授 岩田 想学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA