Antinomicity of the Good-Truth-Beauty Triad on the Internet

The presented article outlines vectors of transformation of basic values of Good-Truth-Beauty in the network. The epistemological, moral-ethical, and aesthetic aspects are offered, which allows revealing the forms of representation of initial values in the Internet culture. In particular, the planes of the intersection of the axes “good/evil”, “truth/lie”, and “beautiful/ugly” in social media are presented. The authors are concerned about the assertion of equivalence and blurring of the boundaries between good and evil, which can lead to permissiveness that is covered by anonymity, symbolism, and nominalisation provided by social networks. The article explores the articulation of the problem of evil in the Internet through the use of the heuristic potential of aesthetic experience. An analysis of modern aesthetic forms of the representation of evil in network culture through the prism of such basic values as Goodness-Truth-Beauty is carried out. It is shown how these values are deformed and sometimes turn into their opposite with the help of aesthetic means. It is shown that modern propaganda, which is carried out in social networks, actively uses existential features of perception and experience of truth. In the course of the study, the opinion is substantiated that reflexive judgment allows to attract aesthetic means to the moral understanding of manifestations of evil in the absence of stable standards and moral guidelines in social networks.</p

Accentuated Peripheral Blood NK Cytotoxicity Forms an Unfavorable Background for Embryo Implantation and Gestation

Problem Many studies have demonstrated the negative impact of high rates of NK cytotoxicity (NKc) on reproductive processes, but there is no agreement as to the appropriateness and feasibility of using the NKc for routine diagnostic in IVF patients. This study conducted a retrospective analysis of embryo transfer (ET) success rates and live birth rates (LBR) in patients with different NKc values. Method of study 1854 cycles of ET were selected and divided into three groups according to NKc levels, and randomized by anamnesis and age: normal (nNKc, n = 871), elevated (eNKc, n = 759), and reduced NKc (rNKc, n = 123). ET with donors&rsquo; embryos (n = 101) were analyzed separately. NKc-to-K562 was measured in PBMC (peripheral blood mononuclear cells) by flow cytometry before ET. The patients did not obtain any additional treatments. Results Patients with eNKc, in addition to having reduced clinical pregnancy rates (OR1.59, p &lt; 0.0001), had increased levels of subsequent pregnancy failures (OR2.545, p &lt; 0.0001) when compared to nNKc patients. As a result, patients with eNKc had almost half the LBR than patients with nNKc (OR2.2, p &lt; 0.0001). In patients with rNKc, LBR was also lowered. eNKc was equally unfavorable for implantation and delivery in cryo- or fresh cycles. Markedly, eNKc was much more unfavorable for reproduction than slightly elevated NKc. The donor&rsquo;s embryos were implanted irrespective of the recipient&rsquo;s NKc levels, but the later stages of pregnancy were worse in patients with eNKc. Conclusions Our findings highlighted the negative impact of high levels of NK cytotoxicity on pregnancy outcomes