Comparative study of the hypoglycemic and biochemical effects of Catharanthus roseus (Linn) g. apocynaceae (Madagascar periwinkle) and chlorpropamide (diabenese) on alloxan-induced diabetic rats

The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes were compared in alloxan-induced diabetic rats. Four groups namely A, B, C and D comprising of nine rats each were used. A and B were administered with chlorpropamide and C. roseus extracts respectively, while C and D served as diabetic and non-diabetic controls respectively. The results showed comparatively significant reductions (P�0.05) in the levels of glucose, protein, cholesterol, lipid peroxidation and liver enzymes in the groups administered C. roseus extracts and chlorpropamide relative to the controls. The reductions were higher in the groups treated with C. roseus extract than in the groups treated with diabenese

Design concept and characterization in select Igbo masquerades

The study of the concepts and motifs in Igbo masquerade design requires an adequate knowledge of the traditional society from and for which the masquerades are created. This knowledge entails an understanding of the worldview of the society that gave it birth. In other words, the Igbo masquerade phenomenon is better understood through an analysis of the concept of mmonwu in Igbo cosmology both as spirit manifests and a performance art. The problem of this study therefore is to interrogate the design concepts and motifs in select Igbo masquerades through which they are characterized and identified. Through an analysis of the design concepts and motifs in Anuka, Agboghommuo, Ajikwu and Ijele masquerades respectively, the study finds that Igbo masquerades are characterized and identified  through the nature of their designs and the philosophy through which they are conceptualized. It thus submits that the Igbo masquerade phenomenon is not fortuitous rather it is an art that encapsulates the Igbo philosophy and worldview. The study therefore recommends the study and analysis of Igbo masquerade designs and motifs as a means of deepening the understanding of the art which  understanding will further position the art in global performance space

A second large plasmid encodes conjugative transfer and antimicrobial resistance in O119:H2 and some typical O111 enteropathogenic \u3ci\u3eEscherichia coli\u3c/i\u3e strains

A novel and functional conjugative transfer system identified in O119:H2 enteropathogenic Escherichia coli (EPEC) strain MB80 by subtractive hybridization is encoded on a large multidrug resistance plasmid, distinct from the well-described EPEC adherence factor (EAF) plasmid. Variants of the MB80 conjugative resistance plasmid were identified in other EPEC strains, including the prototypical O111:NM strain B171, from which the EAF plasmid has been sequenced. This separate large plasmid and the selective advantage that it confers in the antibiotic era have been overlooked because it comigrates with the virulence plasmid on conventional gels

Laying Down the Foundations for International Student Journey. Students as Academic Partners Project Report.

The aim of this project was to explore the lived experiences of being an international student studying at a University within the UK and to make recommendations for future provision. There are increasing numbers of international students studying at Universities within the UK. Positive learning environments and arrangements are the responsibility of the host University and international students’ needs should be taken into consideration. This project was led by international students in collaboration with academic staff. It involved a qualitative exploration of international student perspectives and their experiences of studying within the UK. Ten international students completed a questionnaire that was designed by international students. Respondents were asked questions in relation to three areas: coming to the UK, arriving in the UK and studying in the UK

Chemo-preventive Activity of Ethanolic Extracts of Newbouldia laevis and Olax subscorpioidea Leaves on Methylnitrosourea–induced Stroma Fibrosis in Breast Tissues of Female Albino Rats

Breast cancer represents the most common neoplastic disease in females, accounting for up to one third of new diagnoses of women’s cancer in certain regions of the world. The chemo-preventive activity of ethanolic extracts of Newbouldia laevis and Olax subscorpioidea leaves on methylnitrosourea (MNU)–induced stroma fibrosis in female albino rats was evaluated. Quantitative and qualitative phytochemical screening was carried out to identify and determine the quantity of bioactive compounds. Haematoxylin and Eosin staining procedure was used to assess breast tissues of experimental animals. Cancer antigen (CA) markers 15-3, 27-29 and carcinoembryonic antigen (CEA) in the blood of experimental animals were evaluated using an automated procedure. Quantitative phytochemical screening showed that Olax subscorpioidea and Newbouldia laevis contained alkaloid in the highest amount. Histopathological assay revealed the presence of stromal fibrosis in the breast tissues of 8 out of 10 rats administered with NMU. Levels of CA 15-3, CA 27-29, CEA were significantly (p < 0.05) elevated in MNU administered group in comparison to the negative control. Treatment with Olax subscorpioidea leave extract significantly (p < 0.05) ameliorated CA 15-3, CA 27-29 and CEA levels. However, treatment with Newbouldia laevis leave extract significantly (p < 0.05) ameliorated CA 15-3 and CEA levels only. Findings from this study showed that ethanolic extracts of Olax subscorpioidea and Newbouldia laevis leaves have chemo-preventive activity in NMU-induced stroma fibrosis in the breast tissue of female albino rats. However more studies on the discovery and validation of bioactive components of the plants are needed

English Pronunciation Errors: A Case Study of Amhara and Oromia Regions of Ethiopia

The main goal of this study is oral fluency, that is, the ability to express oneself intelligibly, reasonably, accurately and without too much hesitation without which communication breaks down. In pursuit of this intelligibility between speaker and hearer, the researchers observed through formal and informal settings to find out the deficiencies in the speeches of speakers from the two regions under study that calls for immediate attention. Efforts were made to highlight the pronunciation errors, give possible reasons why they may be occurring and provided plausible solutions. African Research Review Vol. 1 (2) 2007: pp. 160-17

The Woes of Scientific Realism

This paper investigated the disagreement between Realists and Anti-realists on the observable and unobservable distinction in scientific practice. Whilethe realists maintain that machines and gadgets can simulate the human act of perception there-by making all realities under the screen of science observable, the anti-realists or the instrumentalists insist that what cannot be observed with the human senses even if detected with gadgets are not observable. This paper contended against the realist position which says that machines can simulate the human activity of perception. Hence the distinction between what is observable and unobservable is shown to be indisputable

Testing the Optimality of Two Different Non-Parametric Discriminant Methods

This paper aims at comparing the concept of data depth to classification and classification by projection pursuit using method of linear discriminant function. These two methods allow the extension of univariate concepts to the field of multivariate analysis. In particular they open the possibility of non-parametric methods to be used in multivariate data analysis. In this study, six simulated and one real life data sets were studied and, we observed that projection pursuit method is more optimal in classifying objects into their original groups

The effects of rhythm on building openings and fenestrations on airflow pattern in tropical low-rise residential buildings

Effective passive airflow in low-rise residential buildings in hot-humid environment is crucial to maintaining good indoor thermal comfort for occupants. However, investigation of effects of the rhythm of window openings on achieving a passive airflow pattern in such buildings in the tropical climate of sub-Saharan Nigeria have been rarely studied. Therefore, this research aimed to evaluate the effects of the rhythm of window openings on passive airflow patterns for indoor thermal comfort in low-rise residential buildings in the hot-humid environment of Obosi, Nigeria. It involved experimental research using the Anemometer TA465 instrument for measuring wind velocity, relative humidity, and temperature of the purposively designated buildings in the three layouts of the study area for both wet and dry seasons. Employing the Yamane statistical formula, a sample size of 433 was obtained, and questionnaires were administered to occupants of the studied buildings and analyzed using categorical Regression Analysis (CATREG). The regression analysis showed that p=0.000, i.e. p<0.05 indicating that there was a significant relationship between the type and sizes of windows (elements used in measuring rhythm) and the intensity or force of breeze (a measure of passive airflow pattern). Further analysis of the data involved the use of Autodesk CFD 2018 (Computational Fluid Dynamics) for building wind flow simulations. The result showed variations in temperature levels (indications of differences in indoor thermal comfort) of various indoor spaces of the investigated designated floors and buildings, especially ground floors and the top-most floors of the buildings. The study underscored the need to use architectural rhythm design strategies to create a positive impact on airflow patterns in low-rise buildings, especially in densely built-up urban areas. The results of this study are instructive in noting that in order to attain passive airflow in buildings in the face of challenge of land restrictions, vertical stacking of building floors could be used once an adequate rhythm of window openings is adopted