MALIGNANT ONCOCYTOMA OF THE PARANASAL SINUS

A case of malignant oncocytoma developing in the paranasal sinus of a 37-year-old Japanese man with a habit of heavy smoking is described. The primary tumor was found in the right maxillary sinus with local invasion to the nose and right ethmoidal sinus ; it was composed of nests of large oncocytic cells, with finely granular and eosinophilic cytoplasm, nuclear pleomorphism and prominent nucleoli, surrounded by proliferation of spindle-shaped cells in some areas. Electron microscopically, the cytoplasm of oncocytic tumor cells was characterized by abundant mitochondria, and immunohistochemical investigation revealed positive binding for antibodies to S-100 protein and α₁-antitrypsin, but a negative reaction for both cytokeratin and vimentin. At autopsy, metastatic nodules of tumor in the lungs, liver and pancreas independently exhibited both oncocytic cell- and sarcomatous cell compartments. This phenomenon is rare, and to the authors' knowledge, this would be histologically an ususual report of malignant oncocytoma with sarcomatous metastatic nodules arising from the paranasal sinus to be described in the literature

Biyouyanagin A, an Anti-HIV Agent from Hypericum c hinense L. var. s alicifolium

A structurally unique hydrophobic compound, biyouyanagin A, was isolated from the MeOH extract of the leaves of Hypericum chinense L. var. salicifolium. The structure of biyouyanagin A was elucidated on the basis of spectroscopic evidence. Biyouyanagin A showed a significant activity against HIV and inhibited cytokine production

ミンカン ノ ヤクブツイソンショウ リハビリテーション シセツ ニオケル ケイジショブンレキ ノ アル ヤクブツイションショウシャ ノ ジッタイ ト サイハンボウシ ニ カンスル イチコウサツ

背景：薬物依存症者の刑務所への再入所率は非常に高い。目的：民間の薬物依存症リハビリテーション施設に在籍している刑事処分歴のある薬物依存症者の実態を調査し、再犯を防止するための若干の提言を示すことを本研究の目的とした。方法：13の民間の薬物依存症リハビリテーション施設において、刑事処分歴のある薬物依存症者112名を調査した。結果：112名の刑務所入所回数は、平均2.0回であった。また、平均2.7回目の刑務所入所の後に薬物依存症リハビリテーション施設に入寮していた。保釈後、あるいは刑務所出所から再逮捕までの期間は、1年以内が55.3％であった。結論：刑事処分歴のある薬物依存症者は、少なくとも刑務所出所後の1年間は薬物依存症の治療プログラムが必要であると思われた。Background:The percentage of drug-addicts re-entering prison are very high.Objective:We examined drug addicts who were admitted to private drug-rehabilitation institutions with a history of criminal offences/incarcerations. The goal would be to minimize or prevent, even by little, the re-occurrence of criminal offences/incarceration.Methods:This survey was conducted on 112 drug-addicts with a history of criminal offences/incarceration, at 13 various private drug-rehabilitation institutions.Results:The average prison incarceration rate was two times. The drug-addicts were admitted to drug-rehabilitation institutions after an average of 2.7 prison terms. Fromthe time of release, be it released on bail or released from prison, 55.3％ were re-arrested within one year.Conclusion:These results suggest that it is necessary for drug-addicts with a history of criminal offences/incarcerations to receive at least one year of drug-addiction treatment

The Association between OGG1 Ser326Cys Polymorphism and Lung Cancer Susceptibility: A Meta-Analysis of 27 Studies

Background: Numerous studies have investigated association of OGG1 Ser326Cys polymorphism with lung cancer susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis based on 27 publications encompass 9663 cases and 11348 controls to comprehensively evaluate such associations. Methods: We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1 Ser326Cys polymorphism and lung cancer risk. We calculated pooled odds ratio (OR) and 95 % confidence interval (CI) by using either fixed-effects or random-effects model. We used genotype based mRNA expression data from HapMap for SNP rs1052133 in normal cell lines among 270 subjects with four different ethnicities. Results: The results showed that individuals carrying the Cys/Cys genotype did not have significantly increased risk for lung cancer (OR = 1.15, 95 % CI = 0.98–1.36) when compared with the Ser/Ser genotype; similarly, no significant association was found in recessive, dominant or heterozygous co-dominant model (Ser/Cys vs. Cys/Cys). However, markedly increased risks were found in relatively large sample size (Ser/Ser vs. Cys/Cys: OR = 1.29, 95 % CI = 1.13–1.48, and recessive model: OR = 1.19, 95 % CI = 1.07–1.32). As to histological types, we found the Cys/Cys was associated with adenocarcinoma risk (Ser/Ser vs. Cys/Cys: OR = 1.32, 95 % CI = 1.12–1.56; Ser/Cys vs. Cys/Cys: OR = 1.19, 95 % CI = 1.04–1.37, and recessive model OR = 1.23, 95 % CI = 1.08–1.40). No significant difference of OGG1 mRNA expression was found among genotypes between differen

衝撃波加熱プラズマ中の励起準位の緩和過程についての分光的研究

京都大学0048新制・論文博士理学博士乙第2776号論理博第493号新制||理||211(附属図書館)4712UT51-50-J339(主査)教授 中井 祥夫, 教授 巽 友正, 教授 端 恒夫, 教授 田中 茂利学位規則第5条第2項該当Kyoto UniversityDA

Proof-of-Concept of a Millimeter-Wave Integrated Heterogeneous Network for 5G Cellular

The fifth-generation mobile networks (5G) will not only enhance mobile broadband services, but also enable connectivity for a massive number of Internet-of-Things devices, such as wireless sensors, meters or actuators. Thus, 5G is expected to achieve a 1000-fold or more increase in capacity over 4G. The use of the millimeter-wave (mmWave) spectrum is a key enabler to allowing 5G to achieve such enhancement in capacity. To fully utilize the mmWave spectrum, 5G is expected to adopt a heterogeneous network (HetNet) architecture, wherein mmWave small cells are overlaid onto a conventional macro-cellular network. In the mmWave-integrated HetNet, splitting of the control plane (CP) and user plane (UP) will allow continuous connectivity and increase the capacity of the mmWave small cells. mmWave communication can be used not only for access linking, but also for wireless backhaul linking, which will facilitate the installation of mmWave small cells. In this study, a proof-of-concept (PoC) was conducted to demonstrate the practicality of a prototype mmWave-integrated HetNet, using mmWave technologies for both backhaul and access