28 research outputs found
Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
Carcinosarcomas are rare tumors in humans as well as rats and most commonly occur in the
uterus. Recently, we observed a case of incidental carcinosarcoma of the uterus in a
female Wistar Hannover GALAS [BrlHan:WIST@ Jcl (GALAS)] rat at 2 years of age.
Histopathologically, the tumor was characterized by an admixture of malignant epithelial
and nonepithelial elements. The carcinomatous components represented a type of endometrial
carcinoma, consisting of glandular and solid proliferation of large-sized tumor cells.
Prominent mitoses and tumor cell invasion were observed. The sarcomatous components were
characterized by multifocal proliferation of severe atypical cells with cartilage matrix
and were diagnosed as chondrosarcoma. Transitions between carcinomatous and sarcomatous
components were observed, and many tumor cells in the solid lesion showed
immunohistochemical reactivity with both cytokeratin and vimentin. Based on these
findings, this tumor was diagnosed as a uterine carcinosarcoma. This is the first report
of uterine carcinosarcoma in Wistar Hannover GALAS [BrlHan:WIST@Jcl (GALAS)] rats