(3,5-Dimethyl­phen­yl)[8-(3,5-dimethyl­benzo­yl)-2,7-dimeth­oxy­naphthalen-1-yl]methanone

In the title mol­ecule, C30H28O4, the inter­planar angle between the two benzene rings of the 3,5-dimethyl­benzoyl groups is 50.35 (7)°. The dihedral angles between the two benzene rings and the naphthalene ring system are 81.87 (6) and 83.55 (6)°. In addition, the conformations of the pairs of methyl groups and their counterparts differ from each other though their environment is very similar. In the crystal, weak C—H⋯O inter­actions occur

[2,7-Dimeth­oxy-8-(2-naphtho­yl)naphthalen-1-yl](naphthalen-2-yl)methanone

The mol­ecule of the title compound, C34H24O4, possesses crystallographically imposed twofold C 2 symmetry. The two 2-naphthoyl groups at the 1- and 8-positions of the central naphthalene ring are aligned almost anti­parallel [5.21 (5)°]. The dihedral angle between the central 2,7-dimeth­oxy­naphthalene unit and the terminal naphthyl groups is 75.13 (4)°. In the crystal, weak C—H⋯O hydrogen bonds and π–π stacking inter­actions [centroid–centroid and inter­planar distances are 3.6486 (8) and 3.3734 (5) Å, respectively] are observed

7-Meth­oxy-1-(4-nitro­benzo­yl)naph­thalen-2-yl 4-nitro­benzoate

In the title compound, C25H16N2O8, the dihedral angle between the naphthalene ring system and the benzene ring of the nitro­phenyl ketone unit is 82.64 (7)°. The bridging ester O—C(=O)—C plane makes dihedral angles of 42.12 (8) and 11.47 (9)°, respectively, with the naphthalene ring system and the benzene ring of the nitro­phenyl ester unit. In the crystal, two types of weak inter­molecular C—H⋯O inter­actions are observed

Early Parenting Program as Intervention Strategy for Emotional Distress in First-Time Mothers: A Propensity Score Analysis

The purpose of this study is to evaluate the effectiveness of a single session intervention designed to reduce emotional distress in first-time mothers. We held a parenting class for first-time mothers who had given birth at a university hospital in Tokyo, Japan. The program of the class consists of lectures on infant care and group discussion, which is a common form of intervention in Japan. The effectiveness of intervention is assessed according to differences in emotional distress experienced by class participants and nonparticipants, and analyzed by the use of a propensity score method to avoid self-selection bias. In order to be more confident about our results, we employ several variations of this method. Results from statistical analysis show that although the effectiveness of the intervention was limited, it was able to alleviate subjects’ loss of self-confidence as mothers. Because this outcome shows a good degree of consistency across methods, it can be considered robust. Moreover, it is roughly consistent with previous studies. Effectiveness can probably be increased by developing a program that improves upon the intervention

(2,7-Dimeth­oxy­naphthalen-1-yl)(2,4,6-trimethyl­phen­yl)methanone

In the title compound, C22H22O3, the dihedral angle between the naphthalene ring system and the benzene ring is 82.93 (5)°. The bridging carbonyl C—C(=O)—C plane makes dihedral angles of 50.11 (6) and 46.87 (7)°, respectively, with the naphthalene ring system and the benzene ring. In the crystal, three types of weak inter­molecular C—H⋯O inter­actions are observed

Simulated Nanoscale Peeling Process of Monolayer Graphene Sheet - Effect of Edge Structure and Lifting Position

The nanoscale peeling of the graphene sheet on the graphite surface is numerically studied by molecular mechanics simulation. For center-lifting case, the successive partial peelings of the graphene around the lifting center appear as discrete jumps in the force curve, which induce the arched deformation of the graphene sheet. For edge-lifting case, marked atomic-scale friction of the graphene sheet during the nanoscale peeling process is found. During the surface contact, the graphene sheet takes the atomic-scale sliding motion. The period of the peeling force curve during the surface contact decreases to the lattice period of the graphite. During the line contact, the graphene sheet also takes the stick-slip sliding motion. These findings indicate the possibility of not only the direct observation of the atomic-scale friction of the graphene sheet at the tip/surface interface but also the identification of the lattice orientation and the edge structure of the graphene sheet

[8-(4-Chloro­benzo­yl)-2,7-dimeth­oxy­naphthalen-1-yl](2,4,6-trimethyl­phen­yl)methanone

In the title compound, C29H25ClO4, the dihedral angle between the benzene rings of the 2,4,6-trimethyl­benzoyl group and the 4-chloro­benzoyl group is 65.19 (9)°. The dihedral angles between the naphthalene ring system and the benzene rings of the 2,4,6-trimethyl­benzoyl group and the 4-chloro­benzoyl group are 85.66 (8) and 69.48 (8)°, respectively. In the crystal, two types of inter­molecular C—H⋯O inter­actions and an intra­molecular C—H⋯O inter­action are observed. Moreover, there is a short intra­molecular C=O⋯C=O contact of 2.614 (2) Å between the benzoyl substituents

Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients

AbstractThe nef gene is considered to play a crucial role in the development of acquired immunodeficiency syndrome (AIDS). In this study, we analyzed the sequence of nef quasispecies obtained from replication-competent HIV-1 isolates from two Japanese hemophiliac patients infected with HIV-1. At least 10 nef clones were isolated at each time point and a total of 75 individual nef quasispecies were sequenced. We observed a gradual increase in genetic diversity of the nef gene over time. Among the various functional regions of Nef protein, myristoylation site and the central PXXP (SH3 ligand) motifs were well conserved. The scattered regions responsible for downregulation of CD4 and class I MHC were also conserved. These data suggest that these functions of Nef may be involved throughout the disease process

{8-[4-(Bromo­meth­yl)benzo­yl]-2,7-dimeth­oxy­naphthalen-1-yl}[4-(bromo­meth­yl)phen­yl]methanone

In the title compound, C28H22Br2O4, the two 4-bromo­methyl­benzoyl groups at the 1- and 8-positions of the naphthalene ring system are aligned almost anti­parallel, the benzene rings forming a dihedral angle of 2.94 (16)°. The dihedral angles between the benzene rings and the naphthalene ring systems are 70.98 (13) and 72.89 (13)°. In the crystal, centrosymmetric­ally-related mol­ecules are linked into dimeric units by inter­molecular C—H⋯O inter­actions

(3,6-Dimeth­oxy­naphthalen-2-yl)(2,4,6-trimethyl­phen­yl)methanone

In the title compound, C22H22O3, the dihedral angle between the naphthalene ring system and the benzene ring is 79.95 (5)°. The bridging carbonyl C—C(=O)—C group makes dihedral angles of 24.21 (7) and 82.43 (8)°, respectively, with the naphthalene ring system and the benzene ring. In the crystal, weak inter­molecular C—H⋯O inter­actions link mol­ecules into chains parallel to the c axis