EFFECTS OF PROBODY MASSAGE ON PHYSICAL CHARACTERISTICS, BODY ALIGNMENT IN THE MIDDLE-AGED WOMEN WITH MUSCULOSKELETAL DISEASES

The purpose of this study was to investigate the degree of improvement of physical characteristics, body alignment of the exercise group after Probody Massage Program of 8 weeks with 30 musculoskeletal diseases in middle-aged Women in B Metropolitan city. The subjects of this study were 30 musculoskeletal diseases in middle-aged in B Metropolitan city for 8 weeks twice a week, was carried out the Probody Massage Program of 60 minutes. Physiological characteristics are height, weight, BMI, an index of inflammation, body alignment was measured pretest, after 8 weeks. As the Probody Massage Program was showed a positive change in physical characteristics, body alignment with musculoskeletal diseases in middle-aged Women. Consequently it was suggested that Probody Massage with improvement and prevention for posture's unbalance of musculoskeletal diseases in middle-aged Women. This program could be utilized for improvement of youth postures and physical characteristics, body alignment of musculoskeletal diseases in middle-aged Women

Neuroprotective and anti-oxidant effects of caffeic acid isolated from Erigeron annuus leaf

<p>Abstract</p> <p>Background</p> <p>Since oxidative stress has been implicated in a neurodegenerative disease such as Alzheimer's disease (AD), natural antioxidants are promising candidates of chemopreventive agents. This study examines antioxidant and neuronal cell protective effects of various fractions of the methanolic extract of <it>Erigeron annuus </it>leaf and identifies active compounds of the extract.</p> <p>Methods</p> <p>Antioxidant activities of the fractions from <it>Erigeron annuus </it>leaf were examined with [2,2-azino-bis(3-ethylbenz thiazoline-6-sulfonic acid diammonium salt)] (ABTS) and ferric reducing antioxidant power (FRAP) assays. Neuroprotective effect of caffeic acid under oxidative stress induced by H₂O₂was investigated with [3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MTT) and lactate dehydrogenase (LDH) assays.</p> <p>Results</p> <p>This study demonstrated that butanol fraction had the highest antioxidant activity among all solvent fractions from methanolic extract <it>E. annuus </it>leaf. Butanol fraction had the highest total phenolic contents (396.49 mg of GAE/g). Caffeic acid, an isolated active compound from butanol fraction, showed dose-dependent <it>in vitro </it>antioxidant activity. Moreover, neuronal cell protection against oxidative stress induced cytotoxicity was also demonstrated.</p> <p>Conclusion</p> <p><it>Erigeron annuus </it>leaf extracts containing caffeic acid as an active compound have antioxidative and neuroprotective effects on neuronal cells.</p

One-Round Protocol for Two-Party Verifier-Based Password-Authenticated Key Exchange

Abstract. Password-authenticated key exchange (PAKE) for two-party allows a client and a server communicating over a public network to share a session key using a human-memorable password only. PAKE protocols can be served as basic building blocks for constructing secure, complex, and higher-level protocols which were initially built upon the Transport Layer Security (TLS) protocol. In this paper, we propose a provablysecure verifier-based PAKE protocol well suited with the TLS protocol which requires only a single round. The protocol is secure against attacks using compromised server&apos;s password file and known-key attacks, and provides forward secrecy, which is analyzed in the ideal hash model. This scheme matches the most efficient verifier-based PAKE protocol among those found in the literature. It is the first provably-secure one-round protocol for verifier-based PAKE in the two-party setting

The Recognition of Discipline and Abuse in University Students of the Faculty of Education in Korea

　本研究では，韓国の教員養成課程の大学生におけるしつけと虐待に関する認識を明らかにするとともに，しつけと虐待に関する認識は，子どもの頃の経験，虐待に関連する教育を受けた経験や知識の有無等と関連するかを探ることを目的とし，2013 年に韓国の大学５校の協力を得て質問紙調査を行い分析した。分析の結果，本稿で設定した23 行為のうち，７割以上の大学生が「しつけとして行ってよい」と認識した行為は，大声で叱ると手をたたくの２行為，７割以上が「虐待になる」と認識した行為は，やけどを負わせる，一室に閉じ込めるなどの16 行為であること，大学生の多くは，しつけに伴う体罰を容認しながらも，その行為が子どもの心や体を傷つける場合は虐待になると考えており，子どもの頃，親から受けた経験がある行為をしつけとして容認する傾向があることが明らかになった。また，虐待に関する情報に接したり，大学で講義を受けた経験のある学生は，経験のない学生に比べて，虐待に関する認識が高い傾向がみられ，虐待に関連する教育の必要性を確認することができた

Substance P and beta-endorphin mediate electro-acupuncture induced analgesia in mouse cancer pain model

<p>Abstract</p> <p>Background</p> <p>Opioid analgesics are generally used to combat the pain associated with cancerous conditions. These agents not only inhibit respiratory function and cause constipation, but also induce other significant side effects such as addiction and tolerance, all of which further contribute to a reduced quality of life for cancer patients. Thus, in the present study, the effects of electro-acupuncture treatment (EA) on mechanical allodynia were examined in a cancer pain mouse model.</p> <p>Methods</p> <p>In order to produce a neuropathic cancer pain model, S-180 sarcoma cells were inoculated around the sciatic nerve of left legs of Balb/c mice. Magnetic Resonance Imaging (MRI) scanning confirmed the mass of S-180 cancer cells embedded around the sciatic nerve. Mechanical allodynia was most consistently induced in the mouse sarcoma cell line S-180 (2 × 10⁶sarcoma cells)-treated group compared to all the other groups studied. EA stimulation (2 Hz) was administered daily to ST36 (Zusanli) of S-180 bearing mice for 30 min for 9 days after S-180 inoculation.</p> <p>Results</p> <p>EA treatment significantly prolonged paw withdrawal latency from 5 days after inoculation. It also shortened the cumulative lifting duration from 7 days after inoculation, compared to the tumor control. Also, the overexpression of pain peptide substance P in the dorsal horn of the spinal cord was significantly decreased in the EA-treated group compared to the tumor control on Day 9 post inoculation. Furthermore, EA treatment effectively increased the concentration of β-endorphin in blood and brain samples of the mice to a greater extent than that of the tumor control as well as the normal group. The concentration of β-endorphin for EA treatment group increased by 51.457% in the blood and 12.6% in the brain respectively, compared to the tumor control group.</p> <p>Conclusion</p> <p>The findings of this study suggest that a S-180 cancer pain model is useful as a consistent and short time animal model. It also indicated that EA treatment could be used as an alternative therapeutic method for cancer pain due to a consequent decrease in substance P and increase in β-endorphin levels.</p

Identification of HLA-A*2402-restricted HCMV immediate early-1 (IE-1) epitopes as targets for CD8+ HCMV-specific cytotoxic T lymphocytes

<p>Abstract</p> <p>Background</p> <p>To identify novel HLA-A*2402-restricted human cytomegalovirus (HCMV) immediate early-1 (IE-1) epitopes for adoptive immunotherapy, we explored 120 overlapping 15-amino acid spanning IE-1.</p> <p>Methods</p> <p>These peptides were screened by measuring the frequency of polyclonal CD8+ T cells producing intracellular interferon-γ (IFN-γ) using flow cytometry and the epitopes were validated with a HCMV-infected target Cr release cytotoxicity assay.</p> <p>Results</p> <p>Initial screening was performed with 12 mini-pools of 10 consecutive peptides made from 120 overlapping peptides15-amino acids in length that spanned IE-1. When peripheral blood mononuclear cells (PBMCs) from HLA-A*2402 HCMV-seropositive donors were sensitized with each of the 12 mini-pools, mini-pools 1 and 2 induced the highest frequency of CD8+ cytotoxic T lymphocytes (CTLs) producing IFN-γ. When PBMCs were stimulated with each of the twenty peptides belonging to mini-pools 1 and 2, peptides IE-1_1–15MESSAKRKMDPDNPD and IE-1_5–19AKRKMDPDNPDEGPS induced the greatest quantities of IFN-γ production and cytotoxicity of HLA-matched HCMV-infected fibroblasts. To determine the exact HLA-A*2402-restricted epitopes within the two IE-1 proteins, we synthesized a total of twenty-one overlapping 9- or 10 amino acid peptides spanning IE-1_1–15and IE-1_5–19. Peptide IE-1_3–12SSAKRKMDPD induced the greatest quantities of IFN-γ production and target cell killing by CD8+ CTLs.</p> <p>Conclusion</p> <p>HCMV IE-1_3–12SSAKRKMDPD is a HLA-A*2402-restricted HCMV IE-1 epitope that can serve as a common target for CD8+ HCMV-specific CTLs.</p

Direct Observation of Localized Spin Antiferromagnetic Transition in PdCrO2 by Angle-Resolved Photoemission Spectroscopy

We report the first case of the successful measurements of a localized spin antiferromagnetic transition in delafossite-type PdCrO2 by angle-resolved photoemission spectroscopy (ARPES). This demonstrates how to circumvent the shortcomings of ARPES for investigation of magnetism involved with localized spins in limited size of two-dimensional crystals or multi-layer thin films that neutron scattering can hardly study due to lack of bulk compared to surface. Also, our observations give direct evidence for the spin ordering pattern of Cr3+ ions in PdCrO2 suggested by neutron diffraction and quantum oscillation measurements, and provide a strong constraint that has to be satisfied by a microscopic mechanism for the unconventional anomalous Hall effect recently reported in this system.X1118sciescopu