Small Molecule Modulation of GLUT1-Mediated Glucose Transport

The glucose transport protein, GLUT1, is highly expressed in rapidly proliferating cells, including cancer cells, while decreased GLUT1 levels are found in diseases such as GLUT1 deficiency syndrome and Alzheimer’s. There is increased interest in developing GLUT1 inhibitors as novel anticancer therapeutics, and the discovery of compounds that directly stimulate GLUT1 function. This work investigates how small molecules stimulate and/or inhibit GLUT1-mediated glucose transport, either directly or through the AMPK pathway. Using sugar transport assays and docking analyses to explore Ligand–GLUT1 interactions and specificity of binding, we show that: 1) Ligands inhibit GLUT1 by competing with glucose for binding to the exofacial or endofacial sugar binding sites; 2) Subsaturating inhibitor concentrations stimulate sugar uptake; 3) Ligands inhibit GLUT1–, GLUT3– and GLUT4–mediated sugar uptake in HEK293 cells; and 4) Inclusion of a benzonitrile head group on endofacial GLUT1 inhibitors confers greater inhibitory potency. Furthermore, we investigated AMPK-regulated GLUT1 trafficking in cultured blood-brain barrier endothelial cells, and show that inhibition of GLUT1 internalization is not responsible for increased cell surface levels of GLUT1 observed with AMPK activation in these cells. This study provides a framework for screening candidate GLUT1 inhibitors for specificity, and for optimizing drug design and delivery. Our data on transport stimulation at low inhibitor concentrations support the idea that GLUT1 functions as a cooperative oligomer of allosteric alternating access subunits

Built Environment Professionals' Perceptions of the Effectiveness of Building Control Measures in Lagos State

Due to the alarming rate of building collapse, this study assesses building control practices in Lagos state. It examines the effectiveness of building control practices, and it also identifies the factors limiting the capacity of building control practices. To achieve these objectives, quantitative techniques were used in which 61 questionnaires were distributed to selected professionals from contracting firms within the built environment. The sample was selected using the purposive sampling technique. The data collected were processed using mean item score, percentage and ANOVA. The study revealed that not all building control measures were thoroughly observed. It was discovered from the findings that, aside from the measure of processing and scrutinising the building plans for approval, which was duly observed, no other measures were observed, and they are all equally significant. The study also identifies factors that impede adherence to building control practices, such as corruption and the bureaucratic process, which were ranked highest. Hypothesis testing revealed that there is no significant difference among the professionals in their perception of the effectiveness of building control practices. In conclusion, this study recommends regular auditing of the activities of building control agencies due to the prevalence of corruption cases among their members

ANDROID-BASED ESTIMATING APP FOR BUILDERS ON CONSTRUCTION SITES

The discrepancies between the estimated quantities of building materials and the final quantities used during the construction process requires the need to use more accurate techniques in estimating building materials. The study aimed at developing an android-based estimating app for builders on construction sites with the view of increasing accuracy of estimated building materials. The study was carried out in two stages, whereby one part required a survey to ascertain existing practices while the other helped to develop the android application. A survey research design was utilized on Builders in Lagos state in the south-west of Nigeria. Mean scores and correlation matrix was used for the descriptive and inferential statistics. For the design of the android estimation application for Builders, an android studio and Java programming language was used in developing the app. The developed android app was run via the android emulator. The descriptive data revealed that most of the techniques presently used by builders in estimating building materials were traditional methods which were drawn from either manual-based or use of experiential knowledge. Using these techniques were hinged on several factors as identified in the study. An android-based estimating app was developed for Builders with the aim of estimating for concrete works, sandcrete blocks, ceramic tiles and mortar during the construction process. The study recommended the use of information and communication technologies (ICTs) in obtaining accurate building quantities needed during the construction process

An analysis of social media marketing of indigenous construction firms in Nigeria: A tool for sustainable growth

Indigenous construction firms in Nigeria operate in one of the harshest economic climates while competing with their foreign counterparts. ICFs require strategic and innovative marketing skills in selling their products and services to current and prospective clients. The paper examined the use of social media marketing strategies by indigenous construction firms in Nigeria; a tool for sustainable growth. The study used quantitative data through a questionnaire survey instrument at company-level. A total of seventy-nine (79) questionnaires at firm level were utilised. The data collected were presented using stacked bars, radar charts and matrix correlation. The study identified the social media platforms mostly utilised by ICFs and the major barriers resisting the adoption of the innovative marketing strategy in Nigeria. The perceived benefits accrued to ICFs in the use of social media as a marketing tool differs across the type of social media platforms in use by the ICFs. ICFs need to be concerned about image and trust building through a concerted effort in client engagement on social media platforms to improve their brand and reputation. Social media marketing strategies should be integrated with the traditional marketing plans of construction fir

Entrepreneurial Opportunities in the Production of Building Materials

An aspect of an operational nation building would be a country that has a sustainable construction industry whereby it is self-sufficient in the production of its building materials, but that is not the case. The aim of this study was to assess the entrepreneurial opportunities in the production of Building materials. A literature review approach and desk study using secondary data of net income (Profit after tax) during the period 2010 – 2014 of eight (8) building materials companies, publicly listed on the Nigerian Stock Exchange (NSE) were used for the study. From the study, it is evident that there are entrepreneurial prospects in the Housing and infrastructural needs, Maintenance and repairs, need for quality building materials to avoid Building collapse. These entrepreneurial opportunities gives room for huge production of Building materials such as cement, paint, tiles and steel reinforcement. In conclusion, there is a dire need for investment in the production of building materials locally rather than the heavy reliance on importation. In this exasperating times when oil prices have dwindled, the study calls for diversification to other sector. It was recommended that internally and international short term loan acquisition schemes supported by the federal government should be made available to entrepreneurs in production of building materials. Allied facilities such as improved power sector and material protection policy on imported building materials should be fast tracke

Quality of sleep in an HIV population on antiretroviral therapy at an urban tertiary centre in Lagos, Nigeria

Aim. To determine the prevalence of sleep disturbance and its associated characteristics in HIV-positive outpatients on HAART using the PSQI. Methods. Using a cross-sectional design, 300 patients attending the outpatient HIV/AIDS clinic at the Lagos State University Teaching Hospital were recruited. Baseline data obtained included the participants’ demographic data, educational qualification, and marital status. Their treatment history, including duration since HIV diagnosis, the most recent CD4 cell count, and current antiretroviral therapies, was obtained from their case records. Each participant completed the PSQI questionnaire and those with scores ≥5 were diagnosed with poor sleep quality. Results. The participants were made up of 70.7% females and 29.3% males. Their ages ranged between 18 and 74 years with a mean of 38.9 ± 10.3 years. According to the PSQI, 59.3% reported poor sleep quality. The mean score of those with poor quality sleep (9.2 ± 3.3) was comparable to that of those with good quality sleep (1.26 ± 1.4). \u1d443 < 0.001. Significant differences were observed in all the individual components of the PSQI (\u1d443 < 0.001). On multivariate analyses, the independent associations with sleep quality were the duration since HIV diagnosis (\u1d443 = 0.29), efavirenz based regimen (\u1d443 < 0.001), and lower CD4 cell count (\u1d443 < 0.001). Conclusions. Sleep disturbances are quite common in the HIV population even in the era of HAART. Early recognition via routine assessment and effective treatments could prevent the resultant complications and improve quality of life

CONSTRUCTION PROFESSIONALS’ PERCEPTION OF A WEB-BASED RECRUITING SYSTEM FOR SKILLED LABOUR

Globally, the construction industry is experiencing shortage of skilled labour to handle most of its construction projects. There is the need to develop a two-way collaborative technology that adequately connects the available skilled labour to the construction projects where they are needed and vice versa in order to reduce the shortage. By harnessing the strength of web-based technologies, this study intended to evaluate construction professionals’ perception of a web-based recruiting system for skilled labour. The study developed a web-based recruiting system using CSS, HTML, Javascript and MyQSL. System block design and a use case diagram was used to model the web-based systems which are presented in screen shots in this study. A total of one hundred (100) structured questionnaires were distributed to construction professionals in the attitudinal survey on the developed web-based system. The data obtained was analysed and presented using SPSS v21. Statistical tools such as stacked bars, mean score, analysis of variance (ANOVA) and Kruskall Wallis test were utilized. Based on the designed web-based platform, the study revealed that in recruiting skilled labour for construction projects, construction professional are mostly concerned with having the sufficient number of skilled labour which are readily available to the site location, properly screened and obtained through a low-cost recruiting process in order to improve their competitive advantage in the construction industry. The study identified lack of knowledge about using a web-based system, low IT training among skilled labour and inaccurate information supplied by worker as major drawbacks to using a web-based system for sourcing for skilled labour. The study revealed that there was a statistically significant difference in the drawbacks to the use of web-based recruiting system for sourcing for skilled labour among the construction professionals. The study recommended that there is need to increase ICT trainings among construction professionals and its ancillary stakeholders in order to utilize new innovative ICT tools in the construction industry. Innovative ICT tools can be used to complement traditional methods in use in the construction industry so as to enhance the delivery of construction projects

Presence of Social Client Relationship Management within the Nigerian Construction Industry

Client relationship management (CRM) has become a subject matter of interest to both academics and business practitioners. This is because it reflects the need to manage successful and profitable client relationships for organizations. Construction organizations, as well as the construction industry, are vital components of economic development in Nigeria, but many organizations struggle to perform the client relationships expected of them. The use of social media in the present era has given power to the relevant stakeholders to express their perceptions to a very large audience on the social media platforms of construction organizations. The application of social media to marketing is essential to managing client relationships. This research has been carried out to examine the level of awareness and use of social client relationship management (CRM 2.0) in Nigeriancontracting and consulting construction organizations. In other words, the purpose of the study is to examine the level of adoption of social media platforms in client relationship management in the construction industry in Nigeria. The study also assessed the barriers to the adoption of the use of social media platforms in client relationship management. Using a questionnaire survey, a purposive quota sampling technique was utilized for the collection of data from contracting and consulting firms. The findings reveal that contracting and consulting firms have little to no awareness of CRM 2.0. This study suggests that Nigerian construction organizations are still hesitant to implement social media in a business environment and fully adopt CRM 2.0 in the construction industr

IMPACT OF LOGISTICS FACTORS ON MATERIAL PROCUREMENT FOR CONSTRUCTION PROJECTS

The study assessed the impact of logistics factors on material procurement for construction projects. The research was based on a quantitative research design with the use of questionnaire. Convenience sampling technique was used to distribute 85 questionnaires to contractors in Abuja, Nigeria. Data collected were analyzed by means of descriptive statistics such as bar charts and inferential statics like Principal Component Analysis (PCA) and Categorical Regression Analysis. Vendor qualities and competence of procurement officer were found to be the two most critical components required for successful material procurement on construction sites. Moreover, certain factors were found to affect material procurement on site. These factors include: late delivery of materials, inability to forecast activity period with accuracy, delivery inaccuracies, transportation challenges, increased waiting time and supply of poor quality materials. The study recommends that competent procurement officers having good pricing and negotiation skills be appointed for material procurement on construction sites

Factors Affecting Contractors' Bidding Decisions for Construction Projects in Nigeria

Bidding is the most common means by which contractors obtain work. The construction industry accounts for approximately three quarters of the Gross Domestic Product (GDP) in the country. It is generally believed that wrong bidding practice is a major contributor to the construction industry's inefficiency. This means that any improvement in bidding has the potential to enhance the industry's performance, improve the quality of the decision-making process and assist in achieving the strategic objective of contracting organisations. In an effort to uncover the main factors that characterise the bid/no bid decision of contracting organisations, a study to evaluate the factors that affect contractors' decisions to bid for a project and to evaluate the importance of the identified factors to decision makers was conducted. A structured questionnaire was used as the principal instrument for collecting data from respondents. A total sample of 100 was drawn from these collections of construction contractors from Lagos state. Fifty were completed and returned, representing a 50% response rate. Frequency, percentage, mean score and Spearman's correlation were used in analysing data collected for the study. The results indicate that the financial capability of clients, availability of capital and availability of material are the most important factors that contractors consider when making a bid/no bid decision. The study also reveals that competition (number and identity of competitors) does not have significant influence on contractors' bidding decisions. The study recommends that contractors should also build their reputations in the construction industry by acquiring technical competencies and capabilities as these qualities have become important considerations in assessing contractors' competiveness, as well as being key indicators of successful tendering in construction projects