Enhancement of Terrestrial Diffuse X-ray Emission Associated With Coronal Mass Ejection and Geomagnetic Storm

We present an analysis of a Suzaku observation taken during the geomagnetic storm of 2005 August 23-24. We found time variation of diffuse soft X-ray emission when a coronal mass ejection hit Earth and caused a geomagnetic storm. The diffuse emission consists of fluorescent scattering of solar X-rays and exospheric solarwind charge exchange. The former is characterized by a neutral oxygen emission line due to strong heating of the upper atmosphere during the storm time, while the latter is dominated by a sum of C V, C VI, N VI, N VII, O VII, and O VIII emission lines due to the enhanced solar wind flux in the vicinity of the exosphere. Using the solar wind data taken with the ACE and WIND satellites,a time correlation between the solar wind and the strong O VII line flux were investigated. We estimated necessary column densities for the solar X-ray scattering and exospheric SWCX. From these results, we argue that a part of the solar wind ions enter inside the magnetosphere and cause the SWCX reaction.Comment: 33 pages, 16 figures, accepted for publication in PAS

ヒト肝細胞発癌過程の病態解明と新規治療法の開発

金沢大学大学病院研究課題/領域番号:22790637, 研究期間(年度):2010出典：研究課題「ヒト肝細胞発癌過程の病態解明と新規治療法の開発」課題番号22790637（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22790637/）を加工して作

Non-learning Stereo-aided Depth Completion under Mis-projection via Selective Stereo Matching

We propose a non-learning depth completion method for a sparse depth map captured using a light detection and ranging (LiDAR) sensor guided by a pair of stereo images. Generally, conventional stereo-aided depth completion methods have two limiations. (i) They assume the given sparse depth map is accurately aligned to the input image, whereas the alignment is difficult to achieve in practice. (ii) They have limited accuracy in the long range because the depth is estimated by pixel disparity. To solve the abovementioned limitations, we propose selective stereo matching (SSM) that searches the most appropriate depth value for each image pixel from its neighborly projected LiDAR points based on an energy minimization framework. This depth selection approach can handle any type of mis-projection. Moreover, SSM has an advantage in terms of long-range depth accuracy because it directly uses the LiDAR measurement rather than the depth acquired from the stereo. SSM is a discrete process; thus, we apply variational smoothing with binary anisotropic diffusion tensor (B-ADT) to generate a continuous depth map while preserving depth discontinuity across object boundaries. Experimentally, compared with the previous state-of-the-art stereo-aided depth completion, the proposed method reduced the mean absolute error (MAE) of the depth estimation to 0.65 times and demonstrated approximately twice more accurate estimation in the long range. Moreover, under various LiDAR-camera calibration errors, the proposed method reduced the depth estimation MAE to 0.34-0.93 times from previous depth completion methods.Comment: 15 pages, 13 figure

Severity of Tinnitus Distress Negatively Impacts Quality of Life in Patients With Vestibular Schwannoma and Mimics Primary Tinnitus

Objective: Quality of life (QoL) and subjective symptoms are predominantly used to evaluate treatment outcome of patients with vestibular schwannoma (VS). However, for patients undergoing conservative treatment—the most frequently used intervention—the association between QoL and subjective symptoms is unclear. Moreover, it is unknown whether VS-related tinnitus could be associated with the audiological and psychological status of the patient. Our overall aim is to provide objective evidence of this association to better guide treatment of VS.Methods: In a prospective study, we analyzed factors that influence VS-related tinnitus and QoL in 72 patients receiving conservative management of unilateral sporadic VS. This was done through questionnaires that assessed QoL, anxiety, depression, and audiological examinations. We used the SF-36 Short Form to assess QoL; the Tinnitus Handicap Inventory, Dizziness Handicap Inventory, Facial Clinimetric Evaluation Scale, Visual Analog Scale for hearing impairment to assess symptoms subjectively; and pure tone audiometry, the speech discrimination for hearing measurements. For psychological status, we used the Hospital Anxiety and Depression Scale. For analyses, we used Pearson correlation analysis and multiple regression between variables and QoL.Results: Correlation and regression analyses revealed that the severity of tinnitus distress had the largest negative impact on QoL in all domains of SF-36. The severity of tinnitus was significantly associated with subjective hearing impairment and the degree of depression and anxiety. Hearing thresholds had no statistical association with severity of tinnitus.Conclusions: To our knowledge, this is the first study to investigate VS-related tinnitus with respect to both patients' hearing status and psychological condition. Our results suggest that tinnitus distress strongly affects VS patients' QoL and that its characteristics are similar to primary tinnitus. An intervention for VS-related tinnitus, therefore, should assess to what extent tinnitus bothers patients, and it should reduce any unpleasant emotions that may exacerbate symptoms. This approach should improve their QoL

Prenatal Torsion of Radial Polydactyly: A Gangrenous Mass at the Base of the Thumb

A patient was born with a mass at the base of the thumb approximately 1.5 cm in diameter on the radial side of the fingers. The mass had globular swelling filled with hemorrhagic fluid and was dark red. X-rays and histology of the excised specimen suggested the diagnosis of gangrene and torsion of polydactyly. Prenatal torsion of polydactyly is not a common occurrence; moreover, prenatal torsion of polydactyly has only been found in ulnar polydactyly. Our case is a novel case of radial polydactyly that was gangrenous at birth owing to prenatal torsion. Diagnosing such a mass at the base of the thumb is important

Clock mutation affects circadian regulation of circulating blood cells

BACKGROUND: Although the number of circulating immune cells is subject to high-amplitude circadian rhythms, the underlying mechanisms are not fully understood. METHODS: To determine whether intact CLOCK protein is required for the circadian changes in peripheral blood cells, we examined circulating white (WBC) and red (RBC) blood cells in homozygous Clock mutant mice. RESULTS: Daytime increases in total WBC and lymphocytes were suppressed and slightly phase-delayed along with plasma corticosterone levels in Clock mutant mice. The peak RBC rhythm was significantly reduced and phase-advanced in the Clock mutants. Anatomical examination revealed hemoglobin-rich, swollen red spleens in Clock mutant mice, suggesting RBC accumulation. CONCLUSION: Our results suggest that endogenous clock-regulated circadian corticosterone secretion from the adrenal gland is involved in the effect of a Clock mutation on daily profiles of circulating WBC. However, intact CLOCK seems unnecessary for generating the rhythm of corticosterone secretion in mice. Our results also suggest that CLOCK is involved in discharge of RBC from the spleen

Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor – dioxin responsive element signaling pathway

AbstractTunicamycin is a well-known inhibitor of protein glycosylation and used as an inducer of endoplasmic reticulum (ER) stress. We found that tunicamycin induced expression of cytochrome P450 1A1 in a dose-dependent manner. Like dioxin, the transcriptional induction was associated with dose-dependent activation of the dioxin responsive element (DRE). This effect was independent of inhibition of protein glycosylation or induction of ER stress. Pharmacological and genetic inhibition of the aryl hydrocarbon receptor (AhR) significantly attenuated activation of DRE by tunicamycin. These results elucidated the novel potential of tunicamycin as an activator of the AhR – DRE signaling pathway