A regioselective synthesisi of tri- and its application fo the total syntheses of arine alkaloids

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Total syntheses of indole alkaloids, annonidine A and 7-(3-metheyl-2-buten-1-YL)indole

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Modification of Cɛ mRNA Expression by EBV-Encoded Latent Membrane Protein 1

To evaluate the effect of expression of latent membrane protein (LMP) 1 encoded by Epstein-Barr virus (EBV) on Cɛ mRNA expression, mRNA levels were examined by RT-PCR or Northern blot analysis upon transient transfection of LMP1 in the splenocytes derived from Brown-Norway rats with or without immunization with 2,4-dinitrophenyl-conjugated Ascaris suum antigen. Splenocytes were transfected with LMP1 expression vector, pSG5-LMP1, using lipofection method. Cɛ mRNA levels were considerably increased by transfection with pSG5-LMP1 in the splenocytes derived from the nonimmunized rats; however, Cɛ mRNA levels were decreased in the splenocytes derived from the immunized rats. Cɛ mRNA expression in IgE-producing cells are modulated by LMP1, which might depend on the differentiation status of B cells upon exposure to allergen

A simple synthesis of 7-substituted 1-acetyl-2,3-dihydroindoles

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

A regioselective and common synthetic method of dihalogenoindoles and its application for the total syntheses of marine alkaloids, 4,6-dibromo-,4,6-dibromo-2-methyl-, and 3,4,5-tribromoindole

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Si-thall reaction, a method for cross coupline silicon compounds with thallium compounde

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

The Effect of the Dried-Bonito Broth on Blood Pressure, 8-Hydroxydeoxyguanosine (8-OHdG), an Oxidative Stress Marker, and Emotional States in Elderly Subjects

Dried-bonito broth (DBB, katsuo-bushi dashi) is commonly used in Japanese cuisine, and is also used as a traditional remedy for recovery from fatigue and improvement of blood circulation. To clarify the effect of DBB on blood pressure, oxidative stress and emotional states, a randomized crossover human trial was performed. Twenty-seven elderly Japanese subjects ingested DBB or water for one month. Measurement of blood pressure and urinary 8-hydroxydeoxyguanosine (8-OHdG) and evaluation of emotional states were performed before and after the ingestion periods. The changes in systolic blood pressure (SBP) during DBB ingestion was significantly lower than that during water ingestion (p = 0.037). Urinary 8-OHdG significantly decreased during DBB ingestion (p = 0.0002). Evaluation of emotional states indicated that composure significantly improved during DBB ingestion (p = 0.034). These results suggest that the daily ingestion of DBB lower SBP, reduce urinary 8-OHdG and might improve emotional states in elderly subjects

Implications for the Cosmic Reionization from the Optical Afterglow Spectrum of the Gamma-Ray Burst 050904 at z = 6.3

The gamma-ray burst (GRB) 050904 at z = 6.3 provides the first opportunity of probing the intergalactic medium (IGM) by GRBs at the epoch of the reionization. Here we present a spectral modeling analysis of the optical afterglow spectrum taken by the Subaru Telescope, aiming to constrain the reionization history. The spectrum shows a clear damping wing at wavelengths redward of the Lyman break, and the wing shape can be fit either by a damped Ly alpha system with a column density of log (N_HI/cm^{-2}) ~ 21.6 at a redshift close to the detected metal absorption lines (z_metal = 6.295), or by almost neutral IGM extending to a slightly higher redshift of z_{IGM,u} ~ 6.36. In the latter case, the difference from z_metal may be explained by acceleration of metal absorbing shells by the activities of the GRB or its progenitor. However, we exclude this possibility by using the light transmission feature around the Ly beta resonance, leading to a firm upper limit of z_{IGM,u} < 6.314. We then show an evidence that the IGM was largely ionized already at z=6.3, with the best-fit neutral fraction of IGM, x_HI = N_HI/N_H = 0.00, and upper limits of x_HI < 0.17 and 0.60 at 68 and 95% C.L., respectively. This is the first direct and quantitative upper limit on x_HI at z > 6. Various systematic uncertainties are examined, but none of them appears large enough to change this conclusion. To get further information on the reionization, it is important to increase the sample size of z >~ 6 GRBs, in order to find GRBs with low column densities (log N_HI <~ 20) within their host galaxies, and for statistical studies of Ly alpha line emission from host galaxies.Comment: Matches the published version in PASJ. The version with full resolution figures is available upon request to Totani or at http://www.kusastro.kyoto-u.ac.jp/~totani/up/grb050904-paper2-astroph-v3.pd

Syntheses of wasabi phytoalexin (methyl 1-methoxyindole-3-carboxylate) and its 5-iodo derivative, and their nucleophilic substitution reactions

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部A simple synthetic method for methyl 1-methoxyindole-3-carboxylate, a phytoalexin isolated from Wasabia japonica, syn. Eutrema wasabi, and its 5-iodo derivative is reported. They underwent nucleophilic substitution reactions selectively at the 2-position