Calculations of Cotton Effects in the Vacuum UV Region for Chilar v-Lactones. Correlation with the Absolute Stereochemistry

A graphic method of Drude equations was applied to calculate the Cotton effects below 180 nm region for various types of aand/ er y-substituted-y-lactones 1-10. The Cotton effects at ca. 170 nm were found to reflect the stereochemistry at C-2 (negative for f3 and positive for a) and C-4 (positive for f3 and negative for a) as well as the ring conformation (positive for E3 and negative for 3E) of which rotational contributions at 589 nm were suggested as the origin of Hudson\u27s lactone rule

Calculations of Cotton Effects in the Vacuum UV Region for Aldonic Acid 1,4-Lactones and Interpretations of Hudson\u27s Lactone Rule

A graphic method of Drude equation was applied to a series of aldonic acid 1,4-lactones 1-7 to investigate possible Cotton effects below 200nm. The calculation shows three bands at 220nm, 170 nm and 130 nm to reflect the stereochemistries at C-2, C-4 and rtng conformations and vicinal OH at C-3 and C-4, respectively. The sum of the rotational contributions at 589 nm of these bands explained the applicability of Hudson\u27s lactone rule in sugar lactones

Tumor Uptake Study of 18F-labeled N-Acetylneuraminic Acids

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Results of Hepatitis B Vaccination 3 Years After a Primary Vaccine Series in Medical Students

Objective：To investigate the significance of additional hepatitis B （HB） vaccination in medical students who were unresponsive to a primary vaccine series or those who had lost antibody to hepatitis B surface antigen （anti-HBs）.Methods：Subjects were followed up for 3 years after completion of a primary HB vaccine series. One additional dose was given to those who lost the anti-HBs within 3 years after the initial series, while 3 doses were given to those who had not responded to the initial vaccination. Subjects：100 medical students （59 men and 41 women；mean age on admission to university, 19.4±1.6 years） enrolled at the School of Medicine, Dokkyo Medical University in April 2012.Results：The rate of positivity for anti-HBs was 98％ soon after completion of the primary HB vaccine series and decreased without the need for additional vaccination to 79％, 61％, and 55％ at 1, 2, and 3 years after the primary series, respectively. Eighteen vaccinated subjects （18％） lost the anti-HBs 2 years after the primary series, and all of them responded to 1 additional dose. Another 18 successfully vaccinated subjects （18％） were anti-HBs negative both 1 and 2 years after the primary series；17 of them responded to 1 additional dose. As for 2 subjects （2％） who were unresponsive to the primary series, 1 became anti-HBs-positive for the first time after 3 additional doses given 2 years after the primary series.Conclusion：A number of students became or remained anti-HBs negative after the primary HB vaccination, indicating that its timing and dose of additional vaccination need to be studied further to evaluate its utility

Citation Analysis with Medical Subject Headings (MeSH) using the Web of Knowledge: A new routine

Citation analysis of documents retrieved from the Medline database (at the Web of Knowledge) has been possible only on a case-by-case basis. A technique is here developed for citation analysis in batch mode using both Medical Subject Headings (MeSH) at the Web of Knowledge and the Science Citation Index at the Web of Science. This freeware routine is applied to the case of "Brugada Syndrome," a specific disease and field of research (since 1992). The journals containing these publications, for example, are attributed to Web-of-Science Categories other than "Cardiac and Cardiovascular Systems"), perhaps because of the possibility of genetic testing for this syndrome in the clinic. With this routine, all the instruments available for citation analysis can now be used on the basis of MeSH terms. Other options for crossing between Medline, WoS, and Scopus are also reviewed.Comment: Journal of the American Society for Information Science and Technology (2012, in press

(F-18)-2-Deoxy-2-Fluoro-D-Galactose: A Potential Tracer for the Assessment of Sugar Metabolism in the Liver by Positron Emission Tomography

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