Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events

Aims/hypothesis: Diabetes has been shown to be a risk factor for some cancers. Whether diabetes confers the same excess risk of cancer, overall and by site, in women and men is unknown. Methods: A systematic search was performed in PubMed for cohort studies published up to December 2016. Selected studies reported sex-specific relative risk (RR) estimates for the association between diabetes and cancer adjusted at least for age in both sexes. Random-effects meta-analyses with inverse-variance weighting were used to obtain pooled sex-specific RRs and women-to-men ratios of RRs (RRRs) for all-site and site-specific cancers. Results: Data on all-site cancer events (incident or fatal only) were available from 121 cohorts (19,239,302 individuals; 1,082,592 events). The pooled adjusted RR for all-site cancer associated with diabetes was 1.27 (95% CI 1.21, 1.32) in women and 1.19 (1.13, 1.25) in men. Women with diabetes had ~6% greater risk compared with men with diabetes (the pooled RRR was 1.06, 95% CI 1.03, 1.09). Corresponding pooled RRRs were 1.10 (1.07, 1.13) for all-site cancer incidence and 1.03 (0.99, 1.06) for all-site cancer mortality. Diabetes also conferred a significantly greater RR in women than men for oral, stomach and kidney cancer, and for leukaemia, but a lower RR for liver cancer. Conclusions/interpretation: Diabetes is a risk factor for all-site cancer for both women and men, but the excess risk of cancer associated with diabetes is slightly greater for women than men. The direction and magnitude of sex differences varies by location of the cancer

Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals

Aims/hypothesis: The prevalence of diabetes and heart failure is increasing, and diabetes has been associated with an increased risk of heart failure. However, whether diabetes confers the same excess risk of heart failure in women and men is unknown. The aim of this study was to conduct a comprehensive systematic review with meta-analysis of possible sex differences in the excess risk of heart failure consequent to diabetes. Our null hypothesis was that there is no such sex difference. Methods: A systematic search was conducted in PubMed for population-based cohort studies published between January 1966 and November 2018. Studies were selected if they reported sex-specific estimates of RRs for heart failure associated with diabetes, and its associated variability, which were adjusted at least for age. Random-effects meta-analyses with inverse variance weighting were used to obtain pooled sex-specific RRs and women-to-men ratio of RRs (RRRs) for heart failure associated with diabetes. Results: Data from 47 cohorts, involving 12,142,998 individuals and 253,260 heart failure events, were included. The pooled multiple-adjusted RR for heart failure associated with type 1 diabetes was 5.15 (95% CI 3.43, 7.74) in women and 3.47 (2.57, 4.69) in men, leading to an RRR of 1.47 (1.44, 1.90). Corresponding pooled RRs for heart failure associated with type 2 diabetes were 1.95 (1.70, 2.22) in women and 1.74 (1.55, 1.95) in men, with a pooled RRR of 1.09 (1.05, 1.13). Conclusions/interpretation: The excess risk of heart failure associated with diabetes is significantly greater in women with diabetes than in men with diabetes. PROSPERO registration: CRD42019135246

Dynamics of a deformable self-propelled domain

We investigate the dynamical coupling between the motion and the deformation of a single self-propelled domain based on two different model systems in two dimensions. One is represented by the set of ordinary differential equations for the center of gravity and two tensor variables characterizing deformations. The other is an active cell model which has an internal mechanism of motility and is represented by the partial differential equation for deformations. Numerical simulations show a rich variety of dynamics, some of which are common to the two model systems. The origin of the similarity and the difference is discussed.Comment: 6 pages, 6 figure

Degenerate Four Virtual Soliton Resonance for KP-II

By using disipative version of the second and the third members of AKNS hierarchy, a new method to solve 2+1 dimensional Kadomtsev-Petviashvili (KP-II) equation is proposed. We show that dissipative solitons (dissipatons) of those members give rise to the real solitons of KP-II. From the Hirota bilinear form of the SL(2,R) AKNS flows, we formulate a new bilinear representation for KP-II, by which, one and two soliton solutions are constructed and the resonance character of their mutual interactions is studied. By our bilinear form, we first time created four virtual soliton resonance solution for KP-II and established relations of it with degenerate four-soliton solution in the Hirota-Satsuma bilinear form for KP-II.Comment: 10 pages, 5 figures, Talk on International Conference Nonlinear Physics. Theory and Experiment. III, 24 June-3 July, 2004, Gallipoli(Lecce), Ital

Methane Mitigation and Microbial Diversity of Silage Diets Containing Calliandra calothyrsus in a Rumen in Vitro Fermentation System

This study was conducted to investigate the effects of silage based diets on methane (CH4) mitigation and microbial diversity in a rumen in vitro fermentation. The experiment was arranged in a completely randomized design with five treatments and three replications. The dietary treatments consisted of varying levels of silage containing 50% Calliandra calothyrsus as follows K; 100% concentrate + pure tannic acid of 1 mg/mL, R1; 25% silage + 75% concentrate, R2; 50% silage + 50% concentrate, R3; 75% silage + 25% concentrate, and R4; 100% silage. The fermentation variables measured were total gas, CH4, in vitro organic matter digestibility (IVOMD), VFAs, pH, N-NH3, number of protozoa, and microbial diversity analysis. Increasing level of silages reduced total gas production, CH4 concentration, IVOMD, index of bacterial diversity, protozoal number, total methanogens and Methanobacteriales population. Diet with 25% to 50% silage decreased CH4 concentration, total gas production and IVOMD by 11.43%, 24.92%, and 18.73%, respectively. Ammonia N and VFAs (except butyrate and valerate) were significantly reduced (

High-pressure effects on isotropic superconductivity in the iron-free layered pnictide superconductor BaPd2As2

While the layered 122 iron arsenide superconductors are highly anisotropic, unconventional, and exhibit several forms of electronic orders that coexist or compete with superconductivity in different regions of their phase diagrams, we find in the absence of iron in the structure that the superconducting characteristics of the end member BaPd2As2 are surprisingly conventional. Here we report on complementary measurements of specific heat, magnetic susceptibility, resistivity measurements, Andreev spectroscopy, and synchrotron high pressure x-ray diffraction measurements supplemented with theoretical calculations for BaPd2As2. Its superconducting properties are completely isotropic as demonstrated by the critical fields, which do not depend on the direction of the applied field. Under the application of high pressure, Tc is linearly suppressed, which is the typical behavior of classical phonon-mediated superconductors with some additional effect of a pressure-induced decrease in the electronic density of states and the electron-phonon coupling parameters. Structural changes in the layered BaPd2As2 have been studied by means of angle-dispersive diffraction in a diamond-anvil cell. At 12 GPa and 24.2 GPa we observed pressure induced lattice distortions manifesting as the discontinuity and, hence discontinuity in the Birch-Murnaghan equation of state. The bulk modulus is B0=40(6) GPa below 12 GPa and B0=142(3) GPa below 27.2 GPa

Factorization methods for Noncommutative KP and Toda hierarchy

We show that the solution space of the noncommutative KP hierarchy is the same as that of the commutative KP hierarchy owing to the Birkhoff decomposition of groups over the noncommutative algebra. The noncommutative Toda hierarchy is introduced. We derive the bilinear identities for the Baker--Akhiezer functions and calculate the $N$-soliton solutions of the noncommutative Toda hierarchy.Comment: 7 pages, no figures, AMS-LaTeX, minor corrections, final version to appear in Journal of Physics

New magnetic intermediate state, "B - phase, " in the cubic chiral magnet MnSi

It is well known that the archetype chiral magnet MnSi stabilizes a skyrmion lattice, termed "A-phase, "in a narrow temperature range in the vicinity of the paramagnetic boundary around Tc ~29 K and Hc ~2 kOe. Recently, it has been predicted that at much lower temperatures below Tc, the conical helicoid and the forced ferromagnetic (FFM) states could be separated by a new "unknown state."In order to detect this "unknown state, "we explored the phase diagram of MnSi oriented single crystals as a function of the d.c. magnetic field (H - dc) and the temperature (T) by using a.c. magnetization measurements. For H - dc¿ , we observed a new region, termed "B-phase, "in the magnetic phase diagram, characterized by a flat-valley-like anomaly on the in-phase component of the a.c. magnetization (m'), over 3.5 = Hdc = 6.2 kOe just below the low temperature (T or , revealing that the magnetic anisotropy could play a role in the stabilization of the phase. The "B-phase"could be compatible with the theoretical predictions if the new magnetic state is supposedly related with a relative reorientation of the four helices in MnSi