Polylactide (PLA)-based amphiphilic block copolymers: synthesis, self-assembly, and biomedical applications

Polylactide (PLA) and its copolymers are one type of hydrophobic aliphatic polyester based on hydroxyalkanoic acids. They possess exceptional qualities: biocompatibility; FDA approval for clinical use; biodegradability by enzyme and hydrolysis under physiological conditions; low immunogenicity; and good mechanical properties. These critical properties have facilitated their value as sutures, implants for bone fixation, drug delivery vehicles, and tissue engineering scaffolds in pharmaceutical and biomedical applications. However, the hydrophobicity of PLA and its copolymers remains concerns for further biological and biomedical applications. One promising approach is to design and synthesize well-controlled PLA-based amphiphilic block copolymers (ABPs); typical hydrophilic copolymers include poly(meth)acrylates, poly(ethylene glycol), polypeptides, polysaccharides, and polyurethanes. This review summarizes recent advances in the synthesis and self-assembly of PLA-containing ABPs and their bio-related applications including drug delivery and imaging platforms of self-assembled nanoparticles, and tissue engineering of crosslinked hydrogels

Atom transfer radical polymerization in inverse miniemulsion: A versatile route toward preparation and functionalization of microgels/nanogels for targeted drug delivery applications

AbstractThis short review describes application of atom transfer radical polymerization (ATRP) in inverse miniemulsion and disulfide–thiol exchange to prepare well-defined biodegradable functional nanogels (ATRP-nanogels). Due to the formation of uniform network, the ATRP-nanogels have higher swelling ratios, better colloidal stability, and controlled degradation, as compared to nanogels prepared by conventional free-radical polymerization. Various water-soluble biomolecules such as anticancer drugs, carbohydrates, proteins, and star branched polymers were incorporated into ATRP-nanogels at high loading level, by in-situ physical loading or by in-situ chemical incorporation via covalent bonds. The nanogels crosslinked with disulfide or polyester linkages were degraded either in the presence of biocompatible reducing agents or by hydrolysis for controllable release of the encapsulated drugs. ATRP-nanogels contain bromine end groups that enable further chain extension and functionalization with biorelated molecules. They are also easily functionalized by copolymerization with functional monomers or use of functional ATRP initiator during synthesis. These functional nanogels have capability to be further chemically modified and bioconjugated with cell-targeting proteins, antibodies, and integrin-binding peptides to increase cellular uptake via clathrin-mediated endocytosis. These results suggest that such well-defined functional nanogels have great potential for targeted drug delivery applications

Use of Adjacent Knot Data in Predicting Bending Strength of Dimension Lumber by X-Ray

In a previous study, the knot depth ratio (KDR) evaluation method was proposed to quantify the area of knots in a cross-section. That study reported that bending strength can be predicted by KDR analysis. However, the KDR model did not take into consideration the additional strength reduction caused by adjacent knots. It was found that the prediction of lumber strength was improved when adjacent knots were taken into consideration. Analysis using the KDRA (KDR adding knots) model revealed that the optimum cross-sectional interval, an input variable, is directly affected by knot size parallel to lumber length (KSPLL). KSPLL depends on the sawing method and log characteristics, and for species containing large knots, the cross-sectional interval is likely to be extremely wide. This can cause several adjacent small knots to be excluded from the analysis, requiring modification of the KDRA model algorithm. This modification resulted in improvement in the precision of the strength prediction, although the input variable of the cross-sectional interval was not used. The R2 values obtained using this method were 0.60 and 0.56 for Japanese larch and red pine, respectively

Iron oxide-based superparamagnetic polymeric nanomaterials: Design, preparation, and biomedical application

Recent advances in the development and biological applications of polymeric nanomaterials embedded with superparamagneticironoxide nanoparticles (SIONPs) are summarized. Novel SIONP-polymer hybrid nanoparticles are prepared by various methods, including direct modification with polymers, surface-initiated controlled polymerization, inorganic silica/polymer hybridization, self-assembly, self-association, and various heterogeneous polymerization methods. They have potential for various biomedicalapplications, including magnetic resonance imaging (MRI) contrast enhancement, targeted drug delivery, hyperthermia, biological separation, protein immobilization, and biosensors

Development of a Method to Predict the Bending Strength of Lumber Without Regard to Species Using X-Ray Images

Several models have been developed for predicting bending strength of lumber using X-rays, but most require species-specific classifications. However, the classification is very difficult because logs or cants can arrive without leaves or bark. This study was carried out to develop an alternative bending strength prediction model that does not lose precision when the species is unknown. The study proposes an Equivalent Density Model (EDM), in which a cross-section is quantified as equivalent density. Because the relationship between density and strength of small clear specimens is not affected by species, the EDM was expected to correlate to strength regardless of species. This model predicted the modulus of rupture in two species with R2 = 0.73, although the two were mixed. Therefore, it may be possible to predict bending strength using X-rays without classifying lumber by species

Electroactive Artificial Muscles Based on Functionally Antagonistic Core–Shell Polymer Electrolyte Derived from PS-b-PSS Block Copolymer

Electroactive ionic soft actuators, a type of artificial muscles containing a polymer electrolyte membrane sandwiched between two electrodes, have been intensively investigated owing to their potential applications to bioinspired soft robotics, wearable electronics, and active biomedical devices. However, the design and synthesis of an efficient polymer electrolyte suitable for ion migration have been major challenges in developing high-performance ionic soft actuators. Herein, a highly bendable ionic soft actuator based on an unprecedented block copolymer is reported, i.e., polystyrene-b-poly(1-ethyl-3-methylimidazolium-4-styrenesulfonate) (PS-b-PSS-EMIm), with a functionally antagonistic core–shell architecture that is specifically designed as an ionic exchangeable polymer electrolyte. The corresponding actuator shows exceptionally good actuation performance, with a high displacement of 8.22 mm at an ultralow voltage of 0.5 V, a fast rise time of 5 s, and excellent durability over 14 000 cycles. It is envisaged that the development of this high-performance ionic soft actuator could contribute to the progress toward the realization of the aforementioned applications. Furthermore, the procedure described herein can also be applied for developing novel polymer electrolytes related to solid-state lithium batteries and fuel cells

Air-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modification

Polylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties