6 research outputs found
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Research data supporting Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in Schistosoma haematobium and Schistosoma mansoni infection
Individual level S. mansoni infection data obtained from individuals residing in a fishing village in the Lake Victoria region, Uganda, Musoli.
Data include human host age; baseline S. mansoni egg counts, 9-week post-treatment Kato Katz S. mansoni egg counts (eggs/gram feces); 2-year post-treatment Kato Katz S. mansoni egg counts (epg), and post-treatment IgE-TAL titers (ng/ul).
Detailed descriptions of the study cohorts, data collection and analysis can be found in:
Fitzsimmons et al. 2012 DOI:10.1128/IAI.00641-12
Individual level S. haematobium infection data from three villages in the Segou Region, Mali.
Data include human host age, sex and residence in high or moderate transmission intensity villages; pre-treatment baseline CAA measurement; 9-week post-treatment urine filtration S. haematobium egg counts (eggs/10 ml urine); 2-year post-treatment infection status (presence/absence of S. haematobium eggs by urine filtration); post-treatment seroprevalence of measurable IgE responses to specified members of the Tegument Allergen Like protein family (compared to non-endemic control response, data also available); pre-treatment IgE and IgG4 seroprevalence to specific ShTAL proteins; pre- and post-treatment IgE-TAL titers (ng/ul).
Detailed descriptions of the study cohorts, data collection and analysis can be found in:
Wilson et al. 2014 DOI: 10.1093/infdis/jiu374This study was funded by Medical Research Council, UK (grant MR/M019780/1). RCO was funded by the Medical Research Council, UK Doctoral Training Partnership (grant MR/K50127X/1). The original field studies were supported by the Commission of the European Community’s Science and Technology for Development Programme (contract 517733 [MUSTSchistUKEMA])
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Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection.
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S. mansoni. Here we provide the first comprehensive characterization of the S. haematobium Tegument Allergen-Like protein family, a key protein family directly linked to protective immunity in S. mansoni infection. Comparable with observations for S. mansoni, parasite phylogenetic analysis and relative gene expression combined with host serological analysis support a cross-reactive relationship between S. haematobium TAL proteins, exposed to the host immune system as adult worms die, and closely related proteins, exposed during penetration by the infecting cercarial and early schistosomulae stages. Specifically, our results strengthen the evidence for host immunity driven by cross-reactivity between family members TAL3 and TAL5, establishing it for the first time for S. haematobium infection. Furthermore, we build upon this relationship to include the involvement of an additional member of the TAL protein family, TAL11 for both schistosome species. Finally, we show a close association between experience of infection and intensity of transmission and the development of protective IgE responses to these antigens, thus improving our knowledge of the mechanisms by which protective host immune responses develop. This knowledge will be critical in understanding how control efforts such as mass drug administration campaigns influence the development of host immunity and subsequent patterns of infection and disease within endemic populations
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S. mansoni. Here we provide the first comprehensive characterization of the S. haematobium Tegument Allergen-Like protein family, a key protein family directly linked to protective immunity in S. mansoni infection. Comparable with observations for S. mansoni, parasite phylogenetic analysis and relative gene expression combined with host serological analysis support a cross-reactive relationship between S. haematobium TAL proteins, exposed to the host immune system as adult worms die, and closely related proteins, exposed during penetration by the infecting cercarial and early schistosomulae stages. Specifically, our results strengthen the evidence for host immunity driven by cross-reactivity between family members TAL3 and TAL5, establishing it for the first time for S. haematobium infection. Furthermore, we build upon this relationship to include the involvement of an additional member of the TAL protein family, TAL11 for both schistosome species. Finally, we show a close association between experience of infection and intensity of transmission and the development of protective IgE responses to these antigens, thus improving our knowledge of the mechanisms by which protective host immune responses develop. This knowledge will be critical in understanding how control efforts such as mass drug administration campaigns influence the development of host immunity and subsequent patterns of infection and disease within endemic populations
Recommended from our members
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S. mansoni. Here we provide the first comprehensive characterization of the S. haematobium Tegument Allergen-Like protein family, a key protein family directly linked to protective immunity in S. mansoni infection. Comparable with observations for S. mansoni, parasite phylogenetic analysis and relative gene expression combined with host serological analysis support a cross-reactive relationship between S. haematobium TAL proteins, exposed to the host immune system as adult worms die, and closely related proteins, exposed during penetration by the infecting cercarial and early schistosomulae stages. Specifically, our results strengthen the evidence for host immunity driven by cross-reactivity between family members TAL3 and TAL5, establishing it for the first time for S. haematobium infection. Furthermore, we build upon this relationship to include the involvement of an additional member of the TAL protein family, TAL11 for both schistosome species. Finally, we show a close association between experience of infection and intensity of transmission and the development of protective IgE responses to these antigens, thus improving our knowledge of the mechanisms by which protective host immune responses develop. This knowledge will be critical in understanding how control efforts such as mass drug administration campaigns influence the development of host immunity and subsequent patterns of infection and disease within endemic populations.</jats:p