22 research outputs found
Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders
Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy
Evaluation of an ADVanced Organ Support (ADVOS) system in a two-hit porcine model of liver failure plus endotoxemia
Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice
The determinants of research performance in European universities. A large scale multilevel analysis
The paper examines the research performance of European universities in a disaggregated way, using a large array of indicators from Scopus publications, including indicators of volume (number of articles; number of citations) and indicators of quality (percentage of publications in top 10% and top 25% SNIP journals; percentage of citations from top 10% and top 25% journals). These indicators are considered dependent variables in a multi-level estimation framework, in which research performance in a scientific area depends on variables at the level of university and at the level of the external regional environment. The area examined is Medicine, for the 2007–2010 period. The paper exploits for the first time the integration of publication data with the census of European universities (ETER). A large number of hypotheses are tested and discussed
Oxytocin Signaling in Pain: Cellular, Circuit, System, and Behavioral Levels.
Originally confined to the initiation of parturition and milk ejection after birth, the hypothalamic nonapeptide oxytocin (OT) is now recognized as a critical determinant of social behavior and emotional processing. It accounts for the modulation of sensory processing and pain perception as OT displays a potent analgesic effect mediated by OT receptors (OTRs) expressed in the peripheral and central nervous systems. In our chapter, we will first systemically analyze known efferent and afferent OT neuron projections, which form the anatomical basis for OT modulation of somatosensory and pain processing. Next, we will focus on the synergy of distinct types of OT neurons (e.g., magno- and parvocellular OT neurons) which efficiently control acute inflammatory pain perception. Finally, we will describe how OT signaling mechanisms in the spinal cord control nociception, as well as how OT is able to modulate emotional pain processing within the central amygdala. In the conclusions at the end of the chapter, we will formulate perspectives in the study of OT effects on pain anticipation and pain memory, as well as propose some reasons for the application of exogenous OT for the treatment of certain types of pain in human patients