184 research outputs found
Generalized Green-Kubo formulas for fluids with impulsive, dissipative, stochastic and conservative interactions
We present a generalization of the Green-Kubo expressions for thermal
transport coefficients in complex fluids of the generic form, , i.e.
a sum of an instantaneous transport coefficient , and a time
integral over a time correlation function in a state of thermal equilibrium
between a current and a transformed current . The streaming
operator generates the trajectory of a dynamical variable
when used inside the thermal average . These
formulas are valid for conservative, impulsive (hard spheres), stochastic and
dissipative forces (Langevin fluids), provided the system approaches a thermal
equilibrium state. In general and ,
except for the case of conservative forces, where the equality signs apply. The
most important application in the present paper is the hard sphere fluid.Comment: 14 pages, no figures. Version 2: expanded Introduction and section II
specifying the classes of fluids covered by this theory. Some references
added and typos correcte
K–Te photocathodes: A new electron source for photoinjectors
K–Te photocathodes deposited on a Mo substrate have been successfully used as an electron source in the free electron laser of University of Twente. Long lifetimes have been measured: after more than 20 h of operation in the accelerator a K–Te cathode with 4.75% initial quantum efficiency still displays a 1.1% quantum efficiency at 259 nm. Moreover, the quantum efficiency of this cathode versus operation time can be fitted by an exponential decay curve, which saturates asymptotically to a 1.03% value, suggesting that a quantum efficiency close to 1% could be sustained for very long operation times. Films degraded by use can be recovered to a quantum efficiency which is close to the initial value, by heating the substrate at temperatures between 100 and 330 °C. A new procedure to obtain K–Te cathodes with high (up to 11%) quantum efficiencies is described
Swelling-collapse transition of self-attracting walks
We study the structural properties of self-attracting walks in d dimensions
using scaling arguments and Monte Carlo simulations. We find evidence for a
transition analogous to the \Theta transition of polymers. Above a critical
attractive interaction u_c, the walk collapses and the exponents \nu and k,
characterising the scaling with time t of the mean square end-to-end distance
~ t^{2 \nu} and the average number of visited sites ~ t^k, are
universal and given by \nu=1/(d+1) and k=d/(d+1). Below u_c, the walk swells
and the exponents are as with no interaction, i.e. \nu=1/2 for all d, k=1/2 for
d=1 and k=1 for d >= 2. At u_c, the exponents are found to be in a different
universality class.Comment: 6 pages, 5 postscript figure
Parents’ Economic Support of Young-Adult Children: Do Socioeconomic Circumstances Matter?
Analyzing and correcting for contaminating magnetic fields at the Brorfelde geomagnetic observatory due to high voltage DC power lines
Paleo-Immunology: Evidence Consistent with Insertion of a Primordial Herpes Virus-Like Element in the Origins of Acquired Immunity
BACKGROUND:The RAG encoded proteins, RAG-1 and RAG-2 regulate site-specific recombination events in somatic immune B- and T-lymphocytes to generate the acquired immune repertoire. Catalytic activities of the RAG proteins are related to the recombinase functions of a pre-existing mobile DNA element in the DDE recombinase/RNAse H family, sometimes termed the "RAG transposon". METHODOLOGY/PRINCIPAL FINDINGS:Novel to this work is the suggestion that the DDE recombinase responsible for the origins of acquired immunity was encoded by a primordial herpes virus, rather than a "RAG transposon." A subsequent "arms race" between immunity to herpes infection and the immune system obscured primary amino acid similarities between herpes and immune system proteins but preserved regulatory, structural and functional similarities between the respective recombinase proteins. In support of this hypothesis, evidence is reviewed from previous published data that a modern herpes virus protein family with properties of a viral recombinase is co-regulated with both RAG-1 and RAG-2 by closely linked cis-acting co-regulatory sequences. Structural and functional similarity is also reviewed between the putative herpes recombinase and both DDE site of the RAG-1 protein and another DDE/RNAse H family nuclease, the Argonaute protein component of RISC (RNA induced silencing complex). CONCLUSIONS/SIGNIFICANCE:A "co-regulatory" model of the origins of V(D)J recombination and the acquired immune system can account for the observed linked genomic structure of RAG-1 and RAG-2 in non-vertebrate organisms such as the sea urchin that lack an acquired immune system and V(D)J recombination. Initially the regulated expression of a viral recombinase in immune cells may have been positively selected by its ability to stimulate innate immunity to herpes virus infection rather than V(D)J recombination Unlike the "RAG-transposon" hypothesis, the proposed model can be readily tested by comparative functional analysis of herpes virus replication and V(D)J recombination
TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Using a transgenic screen in zebrafish, thymocyte selection–associated high mobility group box protein (TOX) was uncovered as a collaborating oncogenic driver that accelerated T-ALL onset by expanding the initiating pool of transformed clones and elevating genomic instability. TOX is highly expressed in a majority of human T-ALL and is required for proliferation and continued xenograft growth in mice. Using a wide array of functional analyses, we uncovered that TOX binds directly to KU70/80 and suppresses recruitment of this complex to DNA breaks to inhibit nonhomologous end joining (NHEJ) repair. Impaired NHEJ is well known to cause genomic instability, including development of T-cell malignancies in KU70- and KU80-deficient mice. Collectively, our work has uncovered important roles for TOX in regulating NHEJ by elevating genomic instability during leukemia initiation and sustaining leukemic cell proliferation following transformation.
Significance: TOX is an HMG box–containing protein that has important roles in T-ALL initiation and maintenance. TOX inhibits the recruitment of KU70/KU80 to DNA breaks, thereby inhibiting NHEJ repair. Thus, TOX is likely a dominant oncogenic driver in a large fraction of human T-ALL and enhances genomic instability. Cancer Discov; 7(11); 1336–53. ©2017 AACR
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