1,566 research outputs found
Cross-Cultural Content Validity of the Autism Program Environment Rating Scale in Sweden
Increasing rates of autism spectrum disorder (ASD) and younger age at diagnosis pose a challenge to preschool intervention systems. In Sweden, most young autistic children receive intervention service in community-based preschool programs, but no tool is yet available to assess the quality of the preschool learning environment. This study adapted the Autism Program Environment Rating Scale Preschool/Elementary to Swedish community context (APERS-P-SE). Following translation and a multistep modification process, independent experts rated the content validity of the adaptation. Findings indicate high cross-cultural validity of the adapted APERS-P-SE. The cultural adaption process of the APERS-P-SE highlights similarities and differences between the American and Swedish preschool systems and their impact on early ASD intervention
One-electron states and interband optical absorption in single-wall carbon nanotubes
Explicit expressions for the wave functions and dispersion equation for the
band p - electrons in single-wall carbon nanotubes are obtained within the
method of zero-range potentials. They are then used to investigate the
absorption spectrum of polarized light caused by direct interband transitions
in isolated nanotubes. It is shown that, at least, under the above
approximations, the circular dichroism is absent in chiral nanotubes for the
light wave propagating along the tube axis. The results obtained are compared
with those calculated in a similar way for a graphite plane.Comment: 16 pages, 8 figures, 1 tabl
MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis
AbstractThe emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically validated target, deoxyxylulose phosphate reductoisomerase (Dxr). Here we describe RCB-185, a lipophilic prodrug with nanomolar activity against asexual parasites. Growth of P. falciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment substantially reduced metabolite levels downstream of the Dxr enzyme. In addition, parasites that produced higher levels of the Dxr substrate were resistant to RCB-185. Notably, environmental isolates resistant to current therapies remained sensitive to RCB-185, the compound effectively treated sexually-committed parasites, and was both safe and efficacious in malaria-infected mice. Collectively, our data demonstrate that RCB-185 potently and selectively inhibits Dxr in P. falciparum, and represents a promising lead compound for further drug development.</jats:p
Subband population in a single-wall carbon nanotube diode
We observe current rectification in a molecular diode consisting of a
semiconducting single-wall carbon nanotube and an impurity. One half of the
nanotube has no impurity, and it has a current-voltage (I-V) charcteristic of a
typical semiconducting nanotube. The other half of the nanotube has the
impurity on it, and its I-V characteristic is that of a diode. Current in the
nanotube diode is carried by holes transported through the molecule's
one-dimensional subbands. At 77 Kelvin we observe a step-wise increase in the
current through the diode as a function of gate voltage, showing that we can
control the number of occupied one-dimensional subbands through electrostatic
doping.Comment: to appear in Physical Review Letters. 4 pages & 3 figure
Key influences on the initiation and implementation of inclusive preschool programs
This is the publisher's version, also found here: cec.metapress.com
Multiple Functionality in Nanotube Transistors
Calculations of quantum transport in a carbon nanotube transistor show that
such a device offers unique functionality. It can operate as a ballistic
field-effect transistor, with excellent characteristics even when scaled to 10
nm dimensions. At larger gate voltages, channel inversion leads to resonant
tunneling through an electrostatically defined nanoscale quantum dot. Thus the
transistor becomes a gated resonant tunelling device, with negative
differential resistance at a tunable threshold. For the dimensions considered
here, the device operates in the Coulomb blockade regime, even at room
temperature.Comment: To appear in Phys. Rev. Let
Controllability and universal three-qubit quantum computation with trapped electron states
We show how to control and perform universal three-qubit quantum computation
with trapped electron quantum states. The three qubits are the electron spin,
and the first two quantum states of the cyclotron and axial harmonic
oscillators. We explicitly show how the universal gates can be performed. As an
example of a non-trivial quantum algorithm, we outline the implementation of
the Deutsch-Jozsa algorithm in this system.Comment: 4 pages, 1 figure. Typos corrected. The original publication is
available at http://www.springerlink.co
Conductance of carbon nanotubes with disorder: A numerical study
We study the conductance of carbon nanotube wires in the presence of
disorder, in the limit of phase coherent transport. For this purpose, we have
developed a simple numerical procedure to compute transmission through carbon
nanotubes and related structures. Two models of disorder are considered, weak
uniform disorder and isolated strong scatterers. In the case of weak uniform
disorder, our simulations show that the conductance is not significantly
affected by disorder when the Fermi energy is close to the band center.
Further, the transmission around the band center depends on the diameter of
these zero bandgap wires. We also find that the calculated small bias
conductance as a function of the Fermi energy exhibits a dip when the Fermi
energy is close to the second subband minima. In the presence of strong
isolated disorder, our calculations show a transmission gap at the band center,
and the corresponding conductance is very small
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