Outcome Comparisons: Cognitive Outcomes (Change from Baseline between groups).

<p>Results presented as both median with upper and lower quartiles and mean with Standard Deviation.</p><p>MWU – Mann-Whitney U test, SD – Standard Deviation, IQR – Inter Quartile Range.</p>*<p>Statistically significant (p<0·05).</p

CONSORT chart showing flow of participants through the trial.

<p>Assessment of POCD required completion of seven cognitive assessments which were not all completed for all individuals at all timepoints. Presence/absence of POCD was therefore determined as follows throughout the trial. Week 1: Intervention group – 19, Control group – 28; Week 12: Intervention group – 24; Control group – 33; Week 52: Intervention group 27; Control group – 32.</p

RCT Outcome Comparisons: Post-Operative Cognitive Decline (POCD).

<p>POCD at 1 week (n = 19 intervention group, n = 28 control group). POCD at 12 weeks (n = 24 intervention group, n = 33 control group). POCD at 52 weeks (n = 27 intervention group, n = 32 control group).</p

Baseline Sample Characteristics for the RCT.

<p>Baseline Sample Characteristics for the RCT.</p