Technological cost%3CU%2B2010%3Ereduction pathways for axial%3CU%2B2010%3Eflow turbines in the marine hydrokinetic environment.

This report considers and prioritizes potential technical costreduction pathways for axialflow turbines designed for tidal, river, and ocean current resources. This report focuses on technical research and development costreduction pathways related to the device technology rather than environmental monitoring or permitting opportunities. Three sources of information were utilized to understand current cost drivers and develop a list of potential costreduction pathways: a literature review of technical work related to axialflow turbines, the U.S. Department of Energy Reference Model effort, and informal webinars and other targeted interactions with industry developers. Data from these various information sources were aggregated and prioritized with respect to potential impact on the lifetime levelized cost of energy. The four most promising costreduction pathways include structural design optimization; improved deployment, maintenance, and recovery; system simplicity and reliability; and array optimization

Technological cost-reduction pathways for attenuator wave energy converters in the marine hydrokinetic environment.

This report considers and prioritizes the primary potential technical costreduction pathways for offshore wave activated body attenuators designed for ocean resources. This report focuses on technical research and development costreduction pathways related to the device technology rather than environmental monitoring or permitting opportunities. Three sources of information were used to understand current cost drivers and develop a prioritized list of potential costreduction pathways: a literature review of technical work related to attenuators, a reference device compiled from literature sources, and a webinar with each of three industry device developers. Data from these information sources were aggregated and prioritized with respect to the potential impact on the lifetime levelized cost of energy, the potential for progress, the potential for success, and the confidence in success. Results indicate the five most promising costreduction pathways include advanced controls, an optimized structural design, improved power conversion, planned maintenance scheduling, and an optimized device profile

Technological cost-reduction pathways for attenuator wave energy converters in the marine hydrokinetic environment.

This report considers and prioritizes the primary potential technical costreduction pathways for offshore wave activated body attenuators designed for ocean resources. This report focuses on technical research and development costreduction pathways related to the device technology rather than environmental monitoring or permitting opportunities. Three sources of information were used to understand current cost drivers and develop a prioritized list of potential costreduction pathways: a literature review of technical work related to attenuators, a reference device compiled from literature sources, and a webinar with each of three industry device developers. Data from these information sources were aggregated and prioritized with respect to the potential impact on the lifetime levelized cost of energy, the potential for progress, the potential for success, and the confidence in success. Results indicate the five most promising costreduction pathways include advanced controls, an optimized structural design, improved power conversion, planned maintenance scheduling, and an optimized device profile

Technological cost%3CU%2B2010%3Ereduction pathways for axial%3CU%2B2010%3Eflow turbines in the marine hydrokinetic environment.

This report considers and prioritizes potential technical costreduction pathways for axialflow turbines designed for tidal, river, and ocean current resources. This report focuses on technical research and development costreduction pathways related to the device technology rather than environmental monitoring or permitting opportunities. Three sources of information were utilized to understand current cost drivers and develop a list of potential costreduction pathways: a literature review of technical work related to axialflow turbines, the U.S. Department of Energy Reference Model effort, and informal webinars and other targeted interactions with industry developers. Data from these various information sources were aggregated and prioritized with respect to potential impact on the lifetime levelized cost of energy. The four most promising costreduction pathways include structural design optimization; improved deployment, maintenance, and recovery; system simplicity and reliability; and array optimization

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) \u3c 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p \u3c 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained ≤20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations