98 research outputs found
Análisis descriptivo de la población de pacientes diagnosticados de Esclerosis Lateral Amiotrófica en Álava y Alto Deba entre 2012 y 2016
[ES] La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa que afecta a las motoneuronas superiores e inferiores a nivel de la médula espinal, la corteza cerebral y el tronco del encéfalo. La clínica consiste en una debilidad muscular que progresa hasta una parálisis total que produce una dependencia absoluta de los cuidadores. También existe un deterioro progresivo de las funciones deglutoria y respiratoria, la cual es habitualmente la responsable de la muerte del paciente en un periodo que puede durar de 3 a 5 años desde el inicio de los síntomas. La percepción y la cognición suelen estar preservadas
Análisis descriptivo de la población de pacientes diagnosticados de Esclerosis Lateral Amiotrófica en Álava y Alto Deba entre 2012 y 2016
[ES] La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa que afecta a las motoneuronas superiores e inferiores a nivel de la médula espinal, la corteza cerebral y el tronco del encéfalo. La clínica consiste en una debilidad muscular que progresa hasta una parálisis total que produce una dependencia absoluta de los cuidadores. También existe un deterioro progresivo de las funciones deglutoria y respiratoria, la cual es habitualmente la responsable de la muerte del paciente en un periodo que puede durar de 3 a 5 años desde el inicio de los síntomas. La percepción y la cognición suelen estar preservadas
Effective detergent/ chlorophyll ratio and detergent concentration in the aqueous phase during solubilization of Phormidium laminosum membranes
AbstractExperiments of turbidity decrease induced by detergents were systematically performed to characterize the solubilization of Phormidium laminosum membrane fragments. SDS, Triton X-100 and a mixture of octyl glucoside/decyl maltoside/lithium dodecyl sulfate (OG/DM/LiDS, in a molar ratio of 4.19:2.54:1) were used. The detergent concentration in the aqueous phase (Dw) and the effective detergent/chlorophyll ratio in mixed aggregates (Re) were determined. Both parameters increased during the solubilization and in an exponential way in the range from 10 to 90% solubilization. At detergent concentrations which caused the complete solubilization, DW values were close to the described critical micellar concentrations (cmc), but solubilization started at concentrations well below the cmc. At the onset of solubilization five molecules of SDS, one of Triton X-100 and three of the mixture OG/DM/LiDS, per chlorophyll molecule, saturated the membrane fragments. The increase of DW and Re values was characterized by two constants. This permits the design of a model to predict the detergent concentration which produces a desired solubilization of thylakoid membrane fragments for a given chlorophyll concentration
Training future Primary teachers to approach microorganisms through practical activities. Role of students´ emotions and values
Para promover la motivación y el aprendizaje sobre los microorganismos se ha recomendado
implementar actividades prácticas. Sin embargo, los docentes realizan pocas prácticas de Microbiología, área en la
que, al igual que sus alumnos, presentan ideas alternativas. Dada esta situación, es necesario formar a los futuros
docentes en la enseñanza de los microorganismos. En el presente trabajo se describe una práctica para la
enseñanza de conceptos microbiológicos básicos a maestros en formación inicial, así como los resultados de su
implementación en el aprendizaje y las emociones de los participantes. Los resultados muestran que dicha
práctica es efectiva, motivante y bien valorada por los participantes en relación a su futuro profesional;
observándose correlaciones entre estos aspectos. En concreto, se han detectado asociaciones positivas entre las
emociones positivas y los resultados de aprendizaje, y entre estos y el valor otorgado a la práctica; así como una
asociación negativa entre las emociones negativas y los resultados de aprendizaje.In order to foster motivation and learning about microorganisms, the implementation of practical
activities has been recommended. However, Primary teachers rarely perform Microbiology practices, a branch of
science in which they hold some misconceptions, like their students. To reverse this situation, it is necessary to
develop the ability to teach these practices in prospective teachers. In this contribution we describe a practice to
teach basic microbiological concepts to prospective Primary teachers, as well as the effect of its implementation
in students learning outcomes and their emotions. Results show that the practice is effective, motivating and wellvalued
by participants in relation to their professional future, observing correlations between these aspects. In
particular, positive associations between positive emotions and learning outcomes are detected, and between
these and value towards practice; as well as negative association between negative emotions and learning
outcomes
Comedias sueltas del Museo Nacional del Teatro
Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200
Trans-oligomerization of duplicated aminoacyl-tRNA synthetases maintains genetic code fidelity under stress
Aminoacyl-tRNA synthetases (aaRSs) play a key role in deciphering the genetic message by producing charged tRNAs and are equipped with proofreading mechanisms to ensure correct pairing of tRNAs with their cognate amino acid. Duplicated aaRSs are very frequent in Nature, with 25,913 cases observed in 26,837 genomes. The oligomeric nature of many aaRSs raises the question of how the functioning and oligomerization of duplicated enzymes is organized. We characterized this issue in a model prokaryotic organism that expresses two different threonyl-tRNA synthetases, responsible for Thr-tRNAThr synthesis: one accurate and constitutively expressed (T1) and another (T2) with impaired proofreading activity that also generates mischarged Ser-tRNAThr. Low zinc promotes dissociation of dimeric T1 into monomers deprived of aminoacylation activity and simultaneous induction of T2, which is active for aminoacylation under low zinc. T2 either forms homodimers or heterodimerizes with T1 subunits that provide essential proofreading activity in trans. These findings evidence that in organisms with duplicated genes, cells can orchestrate the assemblage of aaRSs oligomers that meet the necessities of the cell in each situation. We propose that controlled oligomerization of duplicated aaRSs is an adaptive mechanism that can potentially be expanded to the plethora of organisms with duplicated oligomeric aaRSs.Ministerio de Economía y Competitividad BFU2010–19544, BFU2013–44686-
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