Exploring UK crime networks

This paper describes our experiences with three different crime networks in the UK: burglary, 'gun' gangs and retail theft. We present an introduction into each of these problems, and highlight some of the issues related to over-simplification of the network analysis. We also review the term `third-generation' analysis, and provide some insights into achieving this, but also conclude that it can be an extremely computationally expensive undertaking

Measuring UK crime gangs

This paper describes the output of a study to tackle the problem of gang-related crime in the UK; we present the intelligence and routinely gathered data available to a UK regional police force, and describe an initial social network analysis of gangs in the Greater Manchester area of the UK between 2000-2006. By applying social network analysis techniques, we attempt to detect the birth of two new gangs based on local features (modularity, cliques) and global features (clustering coefficient). Thus for the future, identifying the changes in these can help us identify the possible birth of new gangs (sub-networks) in the social system. Furthermore, we study the dynamics of these networks globally and locally, and have identified the global characteristics that tell us that they are not random graphs - they are small world graphs - implying that the formation of gangs is not a random event. However, we are not yet able to conclude anything significant about scale-free characteristics due to insufficient sample size

'The First Day of Summer': Parsing Temporal Expressions with Distributed Semantics

Detecting and understanding temporal expressions are key tasks in natural language processing (NLP), and are important for event detection and information retrieval. In the existing approaches, temporal semantics are typically represented as discrete ranges or specific dates, and the task is restricted to text that conforms to this representation. We propose an alternate paradigm: that of distributed temporal semantics—where a probability density function models relative probabilities of the various interpretations. We extend SUTime, a state-of-the-art NLP system to incorporate our approach, and build definitions of new and existing temporal expressions. A worked example is used to demonstrate our approach: the estimation of the creation time of photos in online social networks (OSNs), with a brief discussion of how the proposed paradigm relates to the point- and interval-based systems of time. An interactive demonstration, along with source code and datasets, are available online

CCTV as a Smart Sensor Network

With the emergence of so-called 'smart CCTV' being able to recognise the precursors for disorder and civil disobedience, we present a preliminary study into using available CCTV networks augmented with big social media datasets. We examine the existing CCTV infrastructure in the UK, and use an agent-based simulation to model interactions between people based on friendship networks and features derived from their social media usage, proposing a novel algorithm for detection of psychopathy. Finally, we explore the frequency of crimes occurring within CCTV viewsheds using available UK police crime datasets to illustrate the current limitations of the CCTV infrastructure, as well as the potential ramifications of the stealthy emergence of CCTV networks as the fifth utility in smart cities

Vortex splitting on a planetary scale in the stratosphere by cyclogenesis on a subplanetary scale in the troposphere

It is hypothesized that a splitting of the stratospheric polar vortex and a sudden warming can result when the polar vortex is elongated and a closed cyclonic circulation develops on a subplanetary scale in the troposphere beneath one of its tips. The hypothesis is supported by studying the splitting event in the Southern Hemisphere during spring 2002. Potential vorticity inversion and an inverse modelling technique using the adjoint of a fully nonlinear dynamical model are used to confirm that splitting is sensitive to subplanetary-scale cyclogenesis when it is strong. Examples of stratospheric vortex-splitting events in the Northern Hemisphere are consistent with the hypothesis. The proposed mechanism for splitting contrasts with the commonly accepted one that it is caused by the upward propagation of a planetary wave from the troposphere. It is suggested that the phenomenon is better understood as an example of a vortex interaction rather than as a wave–mean flow interaction

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model of human physiology and an agriculturally important species. In this study, we utilized the CRISPR/Cas9 system to edit the NANOS2 gene in pig embryos to generate offspring with mono-allelic and bi-allelic mutations. We found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline ablation but other aspects of testicular development are normal. Moreover, male pigs with one intact NANOS2 allele and female knockout pigs are fertile. From an agriculture perspective, NANOS2 knockout male pigs are expected to serve as an ideal surrogate for transplantation of donor spermatogonial stem cells to expand the availability of gametes from genetically desirable sires

Incorporating Emotion and Personality-Based Analysis in User-Centered Modelling

Understanding complex user behaviour under various conditions, scenarios and journeys is fundamental to improving the user-experience for a given system. Predictive models of user reactions, responses—and in particular, emotions—can aid in the design of more intuitive and usable systems. Building on this theme, the preliminary research presented in this paper correlates events and interactions in an online social network against user behaviour, focusing on personality traits. Emotional context and tone is analysed and modelled based on varying types of sentiments that users express in their language using the IBM Watson Developer Cloud tools. The data collected in this study thus provides further evidence towards supporting the hypothesis that analysing and modelling emotions, sentiments and personality traits provides valuable insight into improving the user experience of complex social computer systems

Characterization of Spermatogonial Stem Cells Lacking Intercellular Bridges and Genetic Replacement of a Mutation in Spermatogonial Stem Cells

Stem cells have a potential of gene therapy for regenerative medicine. Among various stem cells, spermatogonial stem cells have a unique characteristic in which neighboring cells can be connected by intercellular bridges. However, the roles of intercellular bridges for stem cell self-renewal, differentiation, and proliferation remain to be elucidated. Here, we show not only the characteristics of testis-expressed gene 14 (TEX14) null spermatogonial stem cells lacking intercellular bridges but also a trial application of genetic correction of a mutation in spermatogonial stem cells as a model for future gene therapy. In TEX14 null testes, some genes important for undifferentiated spermatogonia as well as some differentiation-related genes were activated. TEX14 null spermatogonial stem cells, surprisingly, could form chain-like structures even though they do not form stable intercellular bridges. TEX14 null spermatogonial stem cells in culture possessed both characteristics of undifferentiated and differentiated spermatogonia. Long-term culture of TEX14 null spermatogonial stem cells could not be established likely secondary to up-regulation of CDK4 inhibitors and down-regulation of cyclin E. These results suggest that intercellular bridges are essential for both maintenance of spermatogonial stem cells and their proliferation. Lastly, a mutation in Tex14+/− spermatogonial stem cells was successfully replaced by homologous recombination in vitro. Our study provides a therapeutic potential of spermatogonial stem cells for reproductive medicine if they can be cultured long-term

SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes

The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (Aundiff) that expands clonally from single cells (Asingle) to form pairs (Apaired) and chains of 4, 8 and 16 Aaligned spermatogonia. Although stem cell activity is thought to reside in the population of Asingle spermatogonia, new research suggests that clone size alone does not define the stem cell pool. The mechanisms that regulate self-renewal and differentiation fate decisions are poorly understood due to limited availability of experimental tools that distinguish the products of those fate decisions. The pluripotency factor SALL4 (sal-like protein 4) is implicated in stem cell maintenance and patterning in many organs during embryonic development, but expression becomes restricted to the gonads after birth. We analyzed the expression of SALL4 in the mouse testis during the first weeks after birth and in adult seminiferous tubules. In newborn mice, the isoform SALL4B is expressed in quiescent gonocytes at postnatal day 0 (PND0) and SALL4A is upregulated at PND7 when gonocytes have colonized the basement membrane and given rise to spermatogonia. During steady-state spermatogenesis in adult testes, SALL4 expression overlapped substantially with PLZF and LIN28 in Asingle, Apaired and Aaligned spermatogonia and therefore appears to be a marker of undifferentiated spermatogonia in mice. In contrast, co-expression of SALL4 with GFRα1 and cKIT identified distinct subpopulations of Aundiff in all clone sizes that might provide clues about SSC regulation. Collectively, these results indicate that 1) SALL4 isoforms are differentially expressed at the initiation of spermatogenesis, 2) SALL4 is expressed in undifferentiated spermatogonia in adult testes and 3) SALL4 co-staining with GFRα1 and cKIT reveals distinct subpopulations of Aundiff spermatogonia that merit further investigation. © 2013 Gassei, Orwig

Indirect Effects of Wnt3a/β-Catenin Signalling Support Mouse Spermatogonial Stem Cells In Vitro

Proper regulation of spermatogonial stem cells (SSCs) is crucial for sustaining steady-state spermatogenesis. Previous work has identified several paracrine factors involved in this regulation, in particular, glial cell line-derived neurotrophic factor and fibroblast growth factor 2, which promote long-term SSC self-renewal. Using a SSC culture system, we have recently reported that Wnt5a promotes SSC self-renewal through a β-catenin-independent Wnt mechanism whereas the β-catenin-dependent Wnt pathway is not active in SSCs. In contrast, another study has reported that Wnt3a promotes SSC self-renewal through the β-catenin-dependent pathway, as it can stimulate the proliferation of a spermatogonia cell line. To reconcile these two contradictory reports, we assessed Wnt3a effects on SSCs and progenitor cells, rather than a cell line, in vitro. We observed that Wnt3a induced β-catenin-dependent signalling in a large subset of germ cells and increased SSC numbers. However, further investigation revealed that cell populations with greater β-catenin-signalling activity contained fewer SSCs. The increased maintenance of SSCs by Wnt3a coincided with more active cell cycling and the formation of germ cell aggregates, or communities, under feeder-free conditions. Therefore, the results of this study suggest that Wnt3a selectively stimulates proliferation of progenitors that are committed to differentiation or are in the process of exiting the SSC state, leading to enhanced formation of germ cell communities, which indirectly support SSCs and act as an in vitro niche