789 research outputs found
Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Small bowel adenocarcinoma is a rare malignancy associated with a poor prognosis and there is little evidence of effective treatment. Recurrent small bowel adenocarcinoma is an intractable disease for which there is little information available regarding its treatment by palliative therapy. We present a case of recurrent small bowel adenocarcinoma successfully treated by cytoreductive surgery and palliative chemotherapy.</p> <p>Case presentation</p> <p>We report the case of a 72-year-old Japanese female who developed a peritoneal metastasis from recurrent small bowel adenocarcinoma after curative resection and adjuvant chemotherapy with S-1 and polysaccharide K. She underwent cytoreductive surgery followed by chemotherapy with folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K. Subsequently, no sign of a recurrence was observed 42 months after the second operation.</p> <p>Conclusion</p> <p>To the best of our knowledge, this is the first case report of the successful treatment of peritoneal metastasis from small bowel adenocarcinoma by cytoreductive surgery and combination chemotherapy (folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K).</p
Physics on the edge: contour dynamics, waves and solitons in the quantum Hall effect
We present a theoretical study of the excitations on the edge of a
two-dimensional electron system in a perpendicular magnetic field in terms of a
contour dynamics formalism. In particular, we focus on edge excitations in the
quantum Hall effect. Beyond the usual linear approximation, a non-linear
analysis of the shape deformations of an incompressible droplet yields soliton
solutions which correspond to shapes that propagate without distortion. A
perturbative analysis is used and the results are compared to analogous
systems, like vortex patches in ideal hydrodynamics. Under a local induction
approximation we find that the contour dynamics is described by a non-linear
partial differential equation for the curvature: the modified Korteweg-de Vries
equation.
PACS number(s): 73.40.Hm, 02.40.Ma, 03.40.Gc, 11.10.LmComment: 15 pages, 12 embedded figures, submitted to Phys. Rev.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions that interact with signalling effector proteins. Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassing the region around KRAS-specific residue histidine 95 at the helix α3/loop 7/helix α4 interface. We show that these DARPins specifically inhibit KRAS/effector interactions and the dependent downstream signalling pathways in cancer cells. Binding by the DARPins at that region influences KRAS/effector interactions in different ways, including KRAS nucleotide exchange and inhibiting KRAS dimerization at the plasma membrane. These results highlight the importance of targeting the α3/loop 7/α4 interface, a previously untargeted site in RAS, for specifically inhibiting KRAS function
Solitons on the edge of a two-dimensional electron system
We present a study of the excitations of the edge of a two-dimensional
electron droplet in a magnetic field in terms of a contour dynamics formalism.
We find that, beyond the usual linear approximation, the non-linear analysis
yields soliton solutions which correspond to uniformly rotating shapes. These
modes are found from a perturbative treatment of a non-linear eigenvalue
problem, and as solutions to a modified Korteweg-de Vries equation resulting
from a local induction approximation to the nonlocal contour dynamics. We
discuss applications to the edge modes in the quantum Hall effect.Comment: 4 pages, 2 eps figures (included); to appear in Phys. Rev. Letter
Expanding Stereochemical and Skeletal Diversity Using Petasis Reactions and 1,3-Dipolar Cycloadditions
A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is quantified and compared using principal moment-of-inertia shape analysis.Chemistry and Chemical Biolog
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