Rabies in wild and domestic carnivores of Africa : epidemiological and historical associations determined by limited sequence analysis

Virus isolates from three important reservoirs for rabies in Africa (domestic dogs, jackals and yellow mongooses) were compared by their reaction with a panel of monoclonal antibodies directed to the nucleocapsid protein and by the nucleotide sequence of a 200 base pair segment of the nucleocapsid gene. Although antigenically dissimilar, the variants commonly transmitted in dogs and jackals were very closely related by genetic analysis. Phylogenetic analysis and historical accounts support a common lineage for these variants in both past and present reservoirs for rabies in Europe. Two additional variants, distinct from the dog or jackal variant, were found in yellow mongoose samples and nucleotide sequence from these animals showed more divergence than any other group of samples. These variants and a third variant for which no host species could be identified, were shown to form two additional genetic groups only distantly related to each other. These three variants and a previously identified variant in Nigeria may be indigenous to African carnivores.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201