Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: A qualitative systematic review of analgesic efficacy for acute postoperative pain

10.1213/ANE.0b013e3181cf9281Anesthesia and Analgesia11041170-1179AACR

An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs), including both traditional nonselective NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti-inflammatory and analgesic effects. NSAIDs are a necessary choice in pain management because of the integrated role of the COX pathway in the generation of inflammation and in the biochemical recognition of pain. This group of drugs has recently come under scrutiny because of recent focus in the literature on the various adverse effects that can occur when applying NSAIDs. This review will provide an educational update on the current evidence of the efficacy and adverse effects of NSAIDs. It aims to answer the following questions: (1) are there clinically important differences in the efficacy and safety between the different NSAIDs, (2) if there are differences, which are the ones that are more effective and associated with fewer adverse effects, and (3) which are the effective therapeutic approaches that could reduce the adverse effects of NSAIDs. Finally, an algorithm is proposed which delineates a general decision-making tree to select the most appropriate analgesic for an individual patient based on the evidence reviewed

Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain

10.1016/j.ijom.2004.01.020International Journal of Oral and Maxillofacial Surgery338771-776IJOS

Genetics of male infertility: Role of androgen receptor mutations and Y-microdeletions

Annals of the Academy of Medicine Singapore293396-400AAMS

The role of metal-support interaction for CO-free hydrogen from low temperature ethanol steam reforming on Rh-Fe catalysts

10.1039/c6cp05934aPhysical Chemistry Chemical Physics1964199-420