14 research outputs found
AnĂĄlise microscĂłpica do miocĂĄrdio ventricular esquerdo em cĂŁes soropositivos para cinomose
Avaliação antropométrica e dietética de hipertensos atendidos em ambulatório de um hospital universitårio
TRY plant trait database â enhanced coverage and open access
Plant traitsâthe morphological, anatomical, physiological, biochemical and phenological characteristics of plantsâdetermine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of traitâbased plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traitsâalmost complete coverage for âplant growth formâ. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and traitâenvironmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Exercise reduces lung fibrosis involving serotonin/akt signaling.
PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia, which involves aberrant serotonin (5-hydroxytryptamine [5-HT]) and Akt signaling. As protective effects of chronic aerobic training (AT) have been demonstrated in the context of lung injury, this study investigated whether AT attenuates bleomycin-induced lung fibrosis partly via a reduction of 5-HT and AKT signaling. METHODS: Seventy-two C57BL/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi), and Fibrosis + Exercise (Fi + Ex) groups. Bleomycin (1.5 UI·kg) was administered on day 1 and treadmill AT began on day 15 and continued for 60 min·d, 5 d·wk for 4 wk. We evaluated total and differential cell counts in bronchoalveolar lavage (BAL), interleukin (IL)-1β, IL-6, CXCL1/KC, IL-10, tumor necrosis factor α, and transforming growth factor β levels in BAL, collagen content in lung parenchyma, 5-HT levels in BAL fluid and in serum, the expression of 5-HT2B receptor, and Akt phosphorylation in lung tissue. RESULTS: AT reduced bleomycin-increased number of total cells (P < 0.001), neutrophils (P < 0.01), macrophages (P < 0.01), and lymphocytes (P < 0.05) in BAL. It also reduced the levels of IL-1β (P < 0.01), IL-6 (P < 0.05), CXCL1/KC (P < 0.001), tumor necrosis factor α (P < 0.001), and transforming growth factor β (P < 0.001). It increased expression of ant-inflammatory cytokine IL-10 (P < 0.001). It reduced bleomycin-increased 5-HT levels in BAL (P < 0.001) and in serum (P < 0.05). Reductions in collagen fiber deposition (P < 0.01), 5-HT2B receptor expression (P < 0.01), and Akt phosphorylation in lung tissue were observed. CONCLUSIONS: AT accelerates the resolution of lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis partly via attenuation of 5-HT/Akt signaling.  
Estratificação das oportunidades educacionais no Brasil: contextos e desafios para a oferta de ensino em condiçÔes de qualidade para todos
Avaliação da correlação entre as concentraçÔes de poluentes atmosfĂ©ricos e a mortalidade de idosos no municĂpio de Curitiba Evaluation of the correlation between atmospheric pollutant concentrations and elderly mortality in Curitiba
Este estudo tem por objetivo verificar as associaçÔes de curto prazo entre as concentraçÔes de poluentes atmosfĂ©ricos e a mortalidade de idosos no municĂpio de Curitiba (PR). O perĂodo de anĂĄlise compreendeu os anos de 2003 a 2008. Foram realizadas anĂĄlises de correlação simples e de regressĂŁo mĂșltipla, utilizando-se um modelo aditivo generalizado (MAG), para avaliar as relaçÔes entre os poluentes diĂłxido de enxofre (SO2), ozĂŽnio (O3) e partĂculas totais em suspensĂŁo (PTS) e o nĂșmero de Ăłbitos totais (ObT) e por doenças respiratĂłrias (ObR) de pessoas com idade superior a 60 anos. Os resultados obtidos mostraram relaçÔes positivas e estatisticamente significativas entre os nĂveis de PTS e a mortalidade de idosos por todas as causas (ObT), mesmo considerando-se que os nĂveis de PTS atenderam aos padrĂ”es de qualidade do ar para o perĂodo em estudo.<br>This study aims to analyze the short-term association between concentration of atmospheric pollutants and the mortality of elderly in the city of Curitiba (Brazil). The data comprised the period from 2003 to 2008. The relationships between the pollutants sulfur dioxide (SO2), ozone (O3) and total suspended particles (TSP) and the number of total deaths (ObT) and deaths due to respiratory deceases (ObR) of people aged over 60 years were investigated with simple correlation and multiple regression analyses, using a generalized additive model (GAM). The results showed a positive and statistically significant relationship between TSP concentrations and elderly mortality from all causes (ObT), even considering that TSP concentrations met the air quality standards during the period of study