AMS 14C Dates and Major Element Composition of Glass Shards of Late Pleistocene Tephras on Tanegashima Island, Southern Japan

Four late Pleistocene tephra layers—Tane I (Tn1), II (Tn2), III (Tn3), and IV (Tn4) in ascending order—are intercalated between widespread tephras, Kikai-Tozurahara (K-Tz: 95 ka) and Aira-Tn (AT: 30 cal kBP), on Tanegashima Island, in southern Japan. Paleolithic ruins such as the Yokomine C and Tatikiri archaeological sites were excavated from the loam layer between the Tn4 and Tn3 tephras. To refine the chronological framework on the island, we conducted accelerator mass spectrometry (AMS) radiocarbon dating for 2 paleosol and 6 charcoal samples related with the late Pleistocene tephras and the Yokomine C archaeological site. The obtained 14C dates are consistent with the stratigraphy in calendar years, 33 cal kBP for Tn4, 40 cal kBP for Tn3, and 50 cal kBP for Tn2 and Tn1. The charcoal dates from Yokomine C, 32–38 cal kBP, not only constrain the age of Tn4 and Tn3 ashes, but also serve as a possible date for the site. We also measured the major element compositions of volcanic glass shards with EDS-EPMA to characterize these tephras. Although we could not find a possible correlative for Tn3 and Tn4 ashes using major element oxides of the glass shards, i.e. 75–76 wt% in SiO2, the glass chemistry obtained in this study will be valuable in correlating these tephras with their source volcanoes in the near future.The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202

Development of Basic Ability and Instruction Suitable for Each Student in Special Education : Based on Intoroduction and Practice of Optional Subject

We introduced optional subject into the curriculum of special class at the current year. Consequently, instruction which was more suitable for all the students' actual condition was able to be carried out, and all the students have learned very enthusiastically. Three points were suggested as a result. First, clarify a problem of each student by three people (the student, the guardian, and the teacher) at early time of the year. Secondarily, make an appropriate class according to the clarified problem. Thirdly, make the student choose the subject by various viewpoints. The follwing year, we are also going to improve optional subject and to aim at fixing of the basis to each students

Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration

Background/Aims Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using a 19-gauge needle is an efficient sampling method for the diagnosis of lymphadenopathy. This study compared 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma (ML). Methods Patient characteristics, number of needle passes, puncture route, sensitivity, specificity, and accuracy of cytology/histology for lymphadenopathy were analyzed in patients diagnosed with lymphadenopathy by EUS-FNA using conventional or Franseen needles. Results Between 2012 and 2022, 146 patients met the inclusion criteria (conventional [n=70] and Franseen [n=76]). The median number of needle passes was significantly lower in the conventional group than in the Franseen group (3 [1–6] vs. 4 [1–6], p=0.023). There were no significant differences in cytological/histological diagnoses between the two groups. For ML, the immunohistochemical evaluation rate, sensitivity of flow cytometry, and cytogenetic assessment were not significantly different in either group. Bleeding as adverse events (AEs) were observed in three patients in the Franseen group. Conclusions Both the 19-gauge conventional and Franseen needles showed high accuracy in lymphadenopathy and ML classification. Considering sufficient tissue collection and the avoidance of AEs, the use of 19-gauge conventional needles seems to be a good option for the diagnosis of lymphadenopathy

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.

横紋筋肉腫におけるゲノム・エピゲノム異常の全体図を解明 -横紋筋肉腫を4群に分類-. 京都大学プレスリリース. 2015-07-03.Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar histology with frequent PAX3/7 fusions and alterations in cell cycle regulators. In contrast, mostly showing embryonal histology, both E1 and E2 subtypes are characterized by high frequency of CN alterations and/or allelic imbalances, FGFR4/RAS/AKT pathway mutations and PTEN mutations/methylation and in E2, also by p53 inactivation. Despite the better prognosis of embryonal RMS, patients in the E2 are likely to have a poor prognosis. Our results highlight the close relationships of the methylation status and gene mutations with the biological behaviour in RMS

The Creation of School Education Bringing up a Student Carrying Tomorrow (3) : The Valuation of "Compulsory Subjects", "Optional Subjects", and "Integrated Subjects"

The purpose of this study is to show the valuation of "Compulsory Subjects", "Optional Subjects", and "Integrated Subjects", to show the relationship between each subjects and "three abilities", "the ability of recognizing othere senses of value", "the ability of self-expression and communication" and "the ability of decision-making" which defined by the project members. The main result of this study is that we should make up the standards which teachers, students and parents recognize as important abilities

膵癌予後因子としてのリン酸化Heat shock protein 27の重要性

博士(医学)岐阜大学(Gifu University