Constructivism for Philosophers (Be it a Remark on Realism)

Bereft of the illusion of an epistemic vantage point external to science, what should be our commitment towards the categories, concepts and terms of that very science? Should we, despaired of the possibility to found these concepts on rock bottom, adopt empiricist skepticism? Or perhaps the inexistence of external foundations implies, rather, immunity for scientific ontology from epistemological criticism? Philosophy’s “realism debate” died out without providing a satisfactory answer to the dilemma, which was taken over by the neighboring disciplines. The “symmetry principle” of the “Strong Programme” for the sociology of science-the requirement that truth and error receive the same kind of causal explanations-offered one bold metaphysical answer, under the guise of a methodological decree. Recently, however, it has been argued that this solution is not bold enough, that the social constructivists replaced the naïve presumption of an independent nature which adjudicates our beliefs with a mirror-image presumption of a sui generis society which furnishes these beliefs autonomously. The proper metaphysics for a foundationless epistemology,argues Bruno Latour, is one which grants nature and society, object and subject, equal roles in the success and failure of science and technology; one in which history of society merges with a history of things-in-themselves. The paper analyzes the philosophical and methodological motivations and ramifications of this extraordinary suggestion

Baroque Optics and the Disappearance of the Observer: From Kepler’s Optics to Descartes’ Doubt

In the seventeenth century the human observer gradually disappeared from optical treatises. It was a paradoxical process: the naturalization of the eye estranged the mind from its objects. Turned into a material optical instrument, the eye no longer furnished the observer with genuine representations of visible objects. It became a mere screen, on which rested a blurry array of light stains, accidental effects of a purely causal process. It thus befell the intellect to decipher one natural object—a flat image of no inherent epistemic value—as the vague, reversed reflection of another, wholly independent object. In reflecting on and trespassing the boundaries between natural and artificial, orderly and disorderly, this optical paradox was a Baroque intellectual phenomenon; and it was the origin of Descartes’ celebrated doubt— whether we know anything at all

Embodied Empiricism

This is the introduction to a collection of essays on 'embodied empiricism' in early modern philosophy and the life sciences - papers on Harvey, Glisson, Locke, Hume, Bonnet, Lamarck, on anatomy and physiology, on medicine and natural history, etc

WISeREP - An Interactive Supernova Data Repository

We have entered an era of massive data sets in astronomy. In particular, the number of supernova (SN) discoveries and classifications has substantially increased over the years from few tens to thousands per year. It is no longer the case that observations of a few prototypical events encapsulate most spectroscopic information about SNe, motivating the development of modern tools to collect, archive, organize and distribute spectra in general, and SN spectra in particular. For this reason we have developed the Weizmann Interactive Supernova data REPository - WISeREP - an SQL-based database (DB) with an interactive web-based graphical interface. The system serves as an archive of high quality SN spectra, including both historical (legacy) data as well as data that is accumulated by ongoing modern programs. The archive provides information about objects, their spectra, and related meta-data. Utilizing interactive plots, we provide a graphical interface to visualize data, perform line identification of the major relevant species, determine object redshifts, classify SNe and measure expansion velocities. Guest users may view and download spectra or other data that have been placed in the public domain. Registered users may also view and download data that are proprietary to specific programs with which they are associated. The DB currently holds >8000 spectra, of which >5000 are public; the latter include published spectra from the Palomar Transient Factory, all of the SUSPECT archive, the Caltech-Core-Collapse Program, the CfA SN spectra archive and published spectra from the UC Berkeley SNDB repository. It offers an efficient and convenient way to archive data and share it with colleagues, and we expect that data stored in this way will be easy to access, increasing its visibility, usefulness and scientific impact.Comment: To be published in PASP. WISeREP: http://www.weizmann.ac.il/astrophysics/wiserep

A Self-Determination Theory Approach to Work Motivation of Autistic Adults: A Qualitative Exploratory Study.

The study explores work motivation of autistic adults through the lens of Self-Determination Theory (SDT). Twelve autistic employees (ages 28-47; 3 females) participated in semi-structured qualitative interviews about their work experience. Analysis combined inductive and deductive approaches, identifying motivational themes emerging from the interviews, and analyzing them according to SDT concepts. Two major themes emerged: (1) work motivation factors positioned on the self-determination continuum: income and self-reliance; a daily routine; social/familial internalized norms; meaning and contribution; and job interest; and (2) satisfaction of psychological needs at work, postulated by SDT: competence, social-relatedness, and autonomy and structure. Findings are discussed in relation to current literature, and practical applications are suggested for meeting the motivational needs of autistic employees and promoting employment stability

Harnessing Soluble NK Cell Killer Receptors for the Generation of Novel Cancer Immune Therapy

The natural cytotoxic receptors (NCRs) are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The NCRs, which include three members; NKp46, NKp44 and NKp30, are critically involved in NK cytotoxicity against different targets, including a wide range of tumor cells derived from various origins. Even though the tumor ligands of the NCRs have not been identified yet, the selective manner by which these receptors target tumor cells may provide an excellent basis for the development of novel anti-tumor therapies. To test the potential use of the NCRs as anti-tumor agents, we generated soluble NCR-Ig fusion proteins in which the constant region of human IgG1 was fused to the extracellular portion of the receptor. We demonstrate, using two different human prostate cancer cell lines, that treatment with NKp30-Ig, dramatically inhibits tumor growth in vivo. Activated macrophages were shown to mediate an ADCC response against the NKp30-Ig coated prostate cell lines. Finally, the Ig fusion proteins were also demonstrated to discriminate between benign prostate hyperplasia and prostate cancer. This may provide a novel diagnostic modality in the difficult task of differentiating between these highly common pathological conditions

Quantum vortices of strongly interacting photons

Vortices are a hallmark of topologically nontrivial dynamics in nonlinear physics and arise in a huge variety of systems, from space and atmosphere to condensed matter and quantum gases. In optics, vortices manifest as phase twists of the electromagnetic field, commonly formed by the interaction of light and matter. Formation of vortices by effective interaction of light with itself requires strong optical nonlinearity and has therefore been confined, until now, to the classical regime. Here we report on the realization of quantum vortices resulting from a strong photon-photon interaction in a quantum nonlinear optical medium. The interaction causes faster phase accumulation for co-propagating photons. Similarly to a plate pushing water, the local phase accumulation produces a quantum vortex-antivortex pair within the two-photon wavefunction. For three photons, the formation of vortex lines and a central vortex ring attests to a genuine three-photon interaction. The wavefunction topology, governed by two- and three-photon bound states, imposes a conditional phase shift of $\pi$-per-photon, a potential resource for deterministic quantum logic operations.Comment: The first two authors contributed equally to this wor