Observational Tests of Planet Formation Models

We summarize the results of two experiments to address important issues related to the correlation between planet frequencies and properties and the metallicity of the hosts. Our results can usefully inform formation, structural, and evolutionary models of gas giant planets.Comment: 2 pages, no figures. To appear in the proceedings of "IAU conference 249: Exoplanets: Detection, Formation and Dynamics", held in Suzhou, China, 22-26 Oct. 200

Genetic variants in the ErbB4 gene are associated with white matter integrity

Variations in the signalling NRG1-ErbB4 pathway have been associated with genetic susceptibility for both bipolar disorder and schizophrenia, although the underlying neural mechanisms are still uncertain. Reduced integrity of the anterior limb of the internal capsule (ALIC) has been found in association with risk-associated genetic variation in the 5' region of the NRG1 gene. We hypothesised that variation in the gene encoding the NRG1 receptor, ErbB4, would also be associated with reduced ALIC integrity and with cognitive impairments characteristic of individuals with bipolar disorder and schizophrenia. Using diffusion tensor imaging (DTI). we examined the white matter integrity associations of the ErbB4 polymorphism rs4673628, which resides within intron 12 of the gene encoding ErbB4, in 36 healthy individuals. We also sought to clarify the cognitive effects of any findings. We found that genetic variation at the rs4673628 locus in the ErbB4 gene was significantly associated with ALIC white matter integrity which was also significantly and positively associated with mnemonic function. These findings provide further evidence to support a key role of NRG1-ErbB4 signalling in the pathophysiology of major mental disorders