SAFETY OF MELOXICAM IN TREATMENT OF JUVENILE ARTHRITIS IN CHILDREN

The study estimated the safety of meloxicam in prolonged treatment of children with juvenile arthritis (JA). Clinical data and results of endoscopy of 50 patients with JA were analyzed. All patients were switched from diclofenac to meloxicam by different reasons. An estimation of hepatotoxicity of meloxicam compared to other non-steroidal anti-inflammatory drugs (NSAIDs) — diclofenac and nimesulid, was performed. The results of a study show that treatment with meloxicam decreases a risk of gastrointestinal adverse events in patients with JA. Hepatotoxicity rate of NSAIDs was 7,2%. Patients treated with meloxicam had lowest rate of transaminases increase.Key words: children, juvenile rheumatoid arthritis, juvenile chronic arthritis, NSAIDs, gastrotoxicity, hepatotoxicity.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(2):113-118

Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols

The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity —polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure