Using the principle of multiparametric ultrasound for the diagnosis of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Background. The purpose of this study is evaluation of using the principle of multiparametric ultrasound (mp-US) for the diagnosis of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. The investigation was carried out in Kyiv Endocrinology Centre in 2015–2017. Simultaneous ultrasonic examination of abdominal cavity was performed in all 105 patients using the device Soneus P7 (Ultrasign, Ukraine) and included В-mode, Doppler sonography, strain and shear wave elastography, steatography. Results. The examination of the abdominal cavity, quantitative evaluation of fatty liver, stiffness of the liver parenchyma and steatohepatitis were performed all 105 patients with NAFLD and T2DM. Conclusions. The principle of mp-US for detecting NAFLD in patients with T2DM is comprehensive method for the diagnosis of steatosis and steatography, quantitative evaluation of fatty liver, liver stiffness measurement

Liver Stiffness According to Data of Shear Wave Elastography in Patients with Diabetes Mellitus Type 2 and Nonalcoholic Fatty Liver Disease Depending on Activity of NAFLD

Shear wave elastography is one of the most promising non-invasive methods for diagnosis of fibrosis and steatosis in chronic diffuse liver diseases, which can be used as an alternative to biopsy. Given its widespread introduction into clinical practice, the groups of scientists from around the world pay more attention to the study of factors that can affect the measurement and its diagnostic efficacy. Our research devoted to the study of liver parenchyma stiffness changes measured by shear wave elastography/elastometry in patients with nonalcoholic fatty liver disease, according to univariate correlation and multiple linear regression analysis data, showed that independent determinants associated with increasing of liver parenchyma stiffness were degree of insulin resistance, obesity and transaminase activity

Influence of amorphous nanosilica on the parameters of multiparametric ultrasound investigation in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

Background. The purpose of this study was to evaluate the influence of amorphous nanosilica on the indices of multiparametric ultrasound investigation in patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Materials and methods. The research was conducted in Kyiv endocrine centre in 2015–2017. Simultaneous abdominal ultrasound was made in all 105 patients on Soneus P7 device (Ultrasign, Ukraine) and included В-mode, dopplerography (-metry), strain and share wave elastography (-metry), steatography (-metry) with attenuation coefficient measurement to evaluate the effectiveness of treatment. We used amorphous nanosilica in suspension for the treatment of NAFLD. Results. There was found a decrease in the data of the right liver lobe elastography and its size, blood flow velocity of portal vein in the treatment group. Besides, there was also proved the reduction of progression of right lobe liver stiffness, size of the right and left liver lobes, the diameter and blood flow velocity of portal vein in the treatment group. Conclusions. The amorphous nanosilica can be recommended for the treatment of NAFLD in patients with T2DM, because it has hepatoprotective effect due to decrease in the data of right liver lobe elastography and its size, blood flow velocity of portal vein and the reduced progression of right lobe liver stiffness, size of right and left liver lobes, the diameter and blood flow velocity of portal vein