ИСПОЛЬЗОВАНИЕ МАТЕМАТИЧЕСКОЙ МОДЕЛИ ИНФРАКРАСНОЙ СПЕКТРОСКОПИИ СЫВОРОТКИ КРОВИ В ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ ЯЗВЕННОГО КОЛИТА И БОЛЕЗНИ КРОНА У ДЕТЕЙ

Relevance of research. Inflammatory bowel diseases are among the most severe pathologies in pediatric gastroenterology, often lead to disability. Despite the similarity of the clinic, pathogenetic mechanisms, the question of the differential diagnosis of ulcerative colitis and Crohn's disease is relevant in view of their different prognosis and treatment strategy. In recent years, in medical uses infrared spectroscopy of blood serum for the differential diagnosis of various inflammatory diseases, benign and malignant tumors. Besides finding increasing application of mathematical methods for data processing, the so-called mathematical modeling of pathological processes, allowing objectify the survey results for a more accurate diagnosis and prognosis of pathological processes. Objective: improving the differential diagnosis of ulcerative colitis and Crohn's disease in children. Patients: 21 children with ulcerative colitis, 56 children with Crohn's disease and 34 healthy children. The method of infrared spectroscopy of serum and mathematical modeling results through multivariate entropy analysis. Results: the obtained spectral characteristics of blood serum in children with ulcerative colitis and Crohn's disease and in healthy children, as well as "images of disease" in these pathologies. Conclusion: The use of this medical technology reduced the time of diagnosis, which contributes to the timely choice of rational treatment strategies and provides an opportunity to avoid the development of complications, worsening of the disease. Актуальность. Воспалительные заболевания кишечника относятся к одним из самых тяжелых патологий в детской гастроэнтерологии, часто приводящих к инвалидизации. Несмотря на схожесть клиники, патогенетических механизмов, вопрос дифференциальной  диагностики язвенного колита и болезни Крона актуален ввиду их различного прогноза и лечебной тактики. В медицине в последние годы используется инфракрасная спектроскопия сыворотки крови для проведения дифференциальной диагностики различных воспалительных заболеваний, доброкачественных и злокачественных новообразований. Кроме того находят все большее применение методы математической обработки данных, так называемое математическое моделирование патологических процессов, позволяющее объективизировать результаты обследования для более точной диагностики и прогнозирования патологических процессов. Цель исследования: совершенствование дифференциальной диагностики язвенного колита и болезни Крона у детей. Пациенты и методы: 21 ребенок с язвенным колитом, 56 детей с болезнью Крона и 34 практически здоровых ребенка. Использован метод инфракрасной спектроскопии сыворотки крови и математического моделирования результатов путем многомерного энтропийного анализа. Результаты: получены спектральные характеристики сыворотки крови у детей с язвенным колитом и болезнью Крона и у здоровых детей, а также «образы болезни» при этих патологиях. Заключение: использование данной медицинской технологии позволяет сократить сроки постановки диагноза, что способствует своевременному выбору рациональной тактики лечения и дает возможность избежать развития осложнений, утяжеления течения заболевания.

VARIANTS OF NONSPECIFIC ULCERATIVE COLITIS COURSE IN CHILDREN: PREDICTION AND TREATMENT

Nonspecific ulcerative colitis has different masks, which make it hard for diagnostics. The course of the disease has many variants depending on the kind of therapy, its efficiency. prediction the course of the ulcerative colitis is very important to define the long term treatment management in order to increase the therapy efficiency and improve life quality.Key words: nonspecific ulcerative colitis, prediction the course of the disease, therapy, children

SORPTION РATHOGENETIC THERAPY OF ENDOGENOUS INTOXICATION OF PEDIATRIC CHRONIC INFLAMMATORY BOWEL DISEASES

Gut endotoxicosis caused by penetration of bacterial and metabolic toxins from chime on the background of increasing permeability of gut wall is of great importance in pathogenesis of chronic inflammatory bowel diseases (nonspecific ulcerative colitis — NUC and Crohn’s disease). It is accompanied by disturbance of regulating homeostasis system with the following disturbances of organs and systems of toxication. Developed endotoxicosis accordingly contributes to maintain and to progress of metabolic and immunological changes. To obtain the precise degree and phase of development of endotoxicosis we estimated quantitative and qualitative changes of metabolic status in accordance with content in erythrocytes, plasma and urine LMMWP (low and medium molecular weight peptides). Taking into concideration the peculiarities of children endotoxicosis with, we suggested patogenetical absorption therapy. Therefore, the therapeutic complex was added enterosorbent ensoral, which absorb eczo and endogenic toxins and, moreover, positive influence for composition of intestinal microflora. Prominent clinical effect was accompanied by positive dynamics of laboratory-instrumental parameters.Key words: endogenous intoxication, inflammatory bowel diseases, nonspecific ulcerative colitis, Crohn’s disease, low and medium molecular weight peptides, enterosorbents, children

MEDICAL NUTRITION FOR NON SPECIFIC ULCERATIVE COLITIS AND CROHN'S DISEASE IN CHILDREN

Disturbances of nutritive status are typical of patients with non specific ulcerative colitis и crohn's disease with such symptoms as body weight deficiency, disturbance of metabolism associated with the lack of proteins, macro and microelements, energy substrata. Nutrition plays a key role not only in the growth and development processes but also is one of the crucial factors determining the adequacy of the inflammatory response, adaptation compensatory processes. The article considers issues of medicated nutrition under this pathology, including the basic diet, usage of specialized mixes and enteral feeding to correct the protein energy disturbances, and as an independent treatment method.Key words: crohn's disease, non-specific ulcerative colitis, children, diet, enteral feeding, bowel disease

SORPTION РATHOGENETIC THERAPY OF ENDOGENOUS INTOXICATION OF PEDIATRIC CHRONIC INFLAMMATORY BOWEL DISEASES

Gut endotoxicosis caused by penetration of bacterial and metabolic toxins from chime on the background of increasing permeability of gut wall is of great importance in pathogenesis of chronic inflammatory bowel diseases (nonspecific ulcerative colitis — NUC and Crohn’s disease). It is accompanied by disturbance of regulating homeostasis system with the following disturbances of organs and systems of toxication. Developed endotoxicosis accordingly contributes to maintain and to progress of metabolic and immunological changes. To obtain the precise degree and phase of development of endotoxicosis we estimated quantitative and qualitative changes of metabolic status in accordance with content in erythrocytes, plasma and urine LMMWP (low and medium molecular weight peptides). Taking into concideration the peculiarities of children endotoxicosis with, we suggested patogenetical absorption therapy. Therefore, the therapeutic complex was added enterosorbent ensoral, which absorb eczo and endogenic toxins and, moreover, positive influence for composition of intestinal microflora. Prominent clinical effect was accompanied by positive dynamics of laboratory-instrumental parameters.Key words: endogenous intoxication, inflammatory bowel diseases, nonspecific ulcerative colitis, Crohn’s disease, low and medium molecular weight peptides, enterosorbents, children

FUNCTIONAL FECAL INCONTINENCE IN CHILDREN (DIFFERENTIAL DIAGNOSTICS AND TREATMENT APPROACHES)

Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.Key words: encopresis, differential diagnostics, treatment, children

FUNCTIONAL FECAL INCONTINENCE IN CHILDREN (DIFFERENTIAL DIAGNOSTICS AND TREATMENT APPROACHES)

Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.Key words: encopresis, differential diagnostics, treatment, children