Family history and coronary heart disease in Novosibirsk City population (Program WHO-MONICA)

Aim. To study the association between family history and verified coronary heart disease (vCHD) in 25-64-year-old population of Novosibirsk City (data from cross-sectional epidemiological studies). Material and methods. As a part of the program WHO-MONICA, 7111 males and 5523 females from the nonorganized population of Novosibirsk City were examined. To identify independent risk factors for CHD, stepwise multiple logistic regression analysis was performed. Results. Prevalence of CHD in FH was 26.8% in males, and 37.7% in females. Independent factors, significantly increasing vCHD risk in males, were: advanced age (OR=1.10), atherogenicity index (AI) (OR=1.10), body mass index (OR=1.04), arterial hypertension (AH) (OR=1.63), CHD in FH (OR=1.71), AH in sisters (OR=1.63), AH in parents (OR=1.41); and in females: advanced age (OR=1.06), AI (OR=1.13), AH (OR=2.0), mother’s death from myocardial infarction (OR=2.28), father’s intermittent claudication (OR=4.13), diabetes mellitus in parents (OR=1.59). Conclusion. CHD in FH is an independent population risk factor for CHD. Due to its high prevalence and simple assessment, in can be used for identifying high-risk groups in need for primary prevention