Efficiency of Human Plague Vaccination in Tuvinian Natural Plague Focus

Background. Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections. There are eleven natural plague foci in Russian Federation. In Republic Tyva plague endemic territories include Ovyur, Mongun-Taigin and Tes-Hem areas where Y. pestis strains are intermittently isolated from Citellus undulates. Population living at the territory of the natural foci get immunoprophylaxis against plague at complication of epizootic and epidemic conditions.This paper presents the results of monitoring indicators of the immune status of people vaccinated with the plague vaccine living in the territory of the Tuva natural focus.Materials and methods. The study involved 76 volunteers who had not previously been vaccinated. The study included the determination of production IFN-γ, IL-4, TNF-α by blood cells, titers of specific IgG antibodies to the capsule F1 antigen of the Yersinia pestis, and concentrations of immunoglobulins in serum blood, as well as immunophenotyping of blood lymphocytes.Results. In the course of a comprehensive immunological study, features of the development of cellular and humoral reactions in people living in the territory of the Tuva natural plague focus were established in the first months after vaccination. Changes in the concentration dynamics of the main classes of immunoglobulins were accompanied by an increase in the level of specific IgGs to the F1 within 6 months after immunization. In the same period, a significant increase in the production of cytokines, as well as significant changes in terms of the subpopulation composition of the vaccinated blood.Conclusion. It is necessary to note the importance of studying of the human immune status in 1–3 months after plague vaccination as this period coincides with potentially dangerous season from epidemiological point of view. Nevertheless, much important role for improvement of tactics of the specific prevention measures plays the data received after the revaccination

Functional characteristics of serotoninergic nerves stimulating stomach and intestinal contractions

Aim of review. To summarize the study of serotoninergic nerves stimulating the stomach and intestinal contractions. Key points. The authors established the fact that irritation of sympathetic trunk (ST) in in the chest cavity of dogs in most of the cases cause not inhibition, but rather stimulation of stomach contractions. The stimulatory effect is amplified at block of sympathetic nerve by Ornidum, and is eliminated by block of serotoninergic receptors of autonomic ganglia neurons by trimeperidine hydrochloride. It demonstrates that ST partially consists of serotoninergic nerves. Stimulatory effect for the stomach considerably exceeds brake action of sympathetic nerve. Comparative analysis of serotoninergic nerve functional properties versus sympathetic nerve was carried out. Serotoninergic nerve (as well as sympathetic) - is complex structure, that includes sympathetic trunks and their branches innervating internal organs. Conclusion. Block of serotoninergic nerve stimulation function by trimeperidine hydrochloride to our opinion may be the cause of postoperative constipation in patients who received trimeperidine hydrochloride

USE OF CHOLUDEXAN TO TREAT ANTITUBERCULOSIS DRUG-INDUCED LIVER INJURY 1

The efficacy and safety of choludexan used to treat antituberculosis drug-induced liver injury were studied in 80 patients with respiratory organ tuberculosis. The indicators of liver functional test became normal in 20 patients with no history of hepatitis and in the group of patients with tuberculosis concurrent with hepatitis B and C virus infection by days 10 and 15 of choludexan administration, respectively; liver dysfunctions recovered in the group of patients with tuberculosis concurrent with chronic alcoholism at the time exceeding the reference one. In terms of the findings, choludexan may be recommended for the treatment of antituberculosis drug-induced liver injury. Longer choludexan cycles up to 30 days or more should be used in patients with tuberculosis concurrent with chronic alcoholism when the indicators of liver functional tests recover slowly

ПРИМЕНЕНИЕ ПРЕПАРАТА ХОЛУДЕКСАН ДЛЯ ЛЕЧЕНИЯ ЛЕКАРСТВЕННЫХ ПОРАЖЕНИЙ ПЕЧЕНИ, ОБУСЛОВЛЕННЫХ ПРИЕМОМ ПРОТИВОТУБЕРКУЛЕЗНЫХ ПРЕПАРАТОВ

The efficacy and safety of choludexan used to treat antituberculosis drug-induced liver injury were studied in 80 patients with respiratory organ tuberculosis. The indicators of liver functional test became normal in 20 patients with no history of hepatitis and in the group of patients with tuberculosis concurrent with hepatitis B and C virus infection by days 10 and 15 of choludexan administration, respectively; liver dysfunctions recovered in the group of patients with tuberculosis concurrent with chronic alcoholism at the time exceeding the reference one. In terms of the findings, choludexan may be recommended for the treatment of antituberculosis drug-induced liver injury. Longer choludexan cycles up to 30 days or more should be used in patients with tuberculosis concurrent with chronic alcoholism when the indicators of liver functional tests recover slowly.Изучены эффективность и безопасность применения препарата холудексан для лечения лекарственных поражений печени, обусловленных приемом противотуберкулезных препаратов, у 80 больных туберкулезом органов дыхания. У 20 больных, не имевших в анамнезе указания на перенесенный гепатит, нормализация показателей функциональных проб печени произошла к 10-му дню приема холудексана, в группе больных туберкулезом в сочетании с вирусными гепатитами В и С - к 15-му дню приема препарата, в группе больных туберкулезом в сочетании с хроническим алкоголизмом восстановление нарушенных функций печени произошло в сроки, превышающие контрольные. С учетом полученных результатов холудексан может быть рекомендован для лечения лекарственных поражений печени, обусловленных приемом противотуберкулезных препаратов. Больным туберкулезом в сочетании с хроническим алкоголизмом при медленном восстановлении показателей функциональных проб печени следует рекомендовать более длительный курс холудексана - до 30 дней и более