Therapy of Schizoaffective Disorder and Paranoid Schizophrenia with Episodic Course

Background. The use of atypical antipsychotics in schizophrenia contributes to the reduction of psychotic, affective, negative and cognitive disorders.Aims. To evaluate the effectiveness of ziprasidone therapy in patients with schizoaffective disorder and paranoid schizophrenia with episodic course.Materials and methods. In accordance with ICD-10 there were 14 (63.6 %) people with schizoaffective disorder (F25), 8 (36.4 %) people with paranoid schizophrenia, episodic course (F20.x1). Treatment with ziprasidone lasted 42 days. The dose of ziprasidone in 6 patients (27.3 %) was 80 mg, in 10 patients (45.5 %) – 120 mg, in 6 patients (27.3 %) – 160 mg. Evaluation of the effectiveness of ziprasidone therapy was carried out using psychometric scales (PANSS, General clinical impression scale to assess the effectiveness of therapy – CGI-S, CGI-I), adverse events were registered with the UKU scale.Results. The number of respondents was 19 (86.3 %) (reduction of the total score on the PANSS scale > 20 % of the pre-treatment level). Ziprasidone was effective in patients with schizoaffective disorder with a significant decrease in total score on PANSS subscales to the 14 th day of therapy (p < 0.05), with paranoid schizophrenia with episodic course – by the 21st day (p < 0.01). According to the CGI-S scale at the end of therapy, “borderline condition” was observed in 10 patients (52.6 %), mild severity – in 3 (15.8 %), normal condition – in 6 (31.6 %). CGI-I scale showed a significant improvement in 10 patients (52.6 %), marked improvement – in 9 patients (47.4 %). Among the mild adverse events that do not require discontinuation of the drug, we noted: weakness – in 3 patients (15.8 %), drowsiness – in 3 (15.8 %), impaired concentration – in 2 (10.5 %), orthostatic dizziness – in 2 (10.5 %), galactorrhea – in 1 (5.3 %).Conclusions. Ziprasidone is an effective antipsychotic drug that has a safe tolerability profile. It can be used in patients with schizoaffective disorders and paranoid schizophrenia with episodic course

Diffuse-Charge Dynamics in Electrochemical Systems

The response of a model micro-electrochemical system to a time-dependent applied voltage is analyzed. The article begins with a fresh historical review including electrochemistry, colloidal science, and microfluidics. The model problem consists of a symmetric binary electrolyte between parallel-plate, blocking electrodes which suddenly apply a voltage. Compact Stern layers on the electrodes are also taken into account. The Nernst-Planck-Poisson equations are first linearized and solved by Laplace transforms for small voltages, and numerical solutions are obtained for large voltages. The ``weakly nonlinear'' limit of thin double layers is then analyzed by matched asymptotic expansions in the small parameter $\epsilon = \lambda_D/L$, where $\lambda_D$ is the screening length and $L$ the electrode separation. At leading order, the system initially behaves like an RC circuit with a response time of $\lambda_D L / D$ (not $\lambda_D^2/D$), where $D$ is the ionic diffusivity, but nonlinearity violates this common picture and introduce multiple time scales. The charging process slows down, and neutral-salt adsorption by the diffuse part of the double layer couples to bulk diffusion at the time scale, $L^2/D$. In the ``strongly nonlinear'' regime (controlled by a dimensionless parameter resembling the Dukhin number), this effect produces bulk concentration gradients, and, at very large voltages, transient space charge. The article concludes with an overview of more general situations involving surface conduction, multi-component electrolytes, and Faradaic processes.Comment: 10 figs, 26 pages (double-column), 141 reference

About the time rates for the provision of primary health care to the adult population by the precinct psychiatric doctor

One of the main tasks of domestic health care is the rational use of financial, material and technical and human resources, taking into account the medical and economic effectiveness of the measures taken. An important section in this direction is the optimization of the staffing list of a medical organization based on the needs for medical care and relevant standard labor standards. One of the main tools for creating a staffing table is the regulation of labor, the organization and implementation of which is becoming increasingly relevant in the current conditions of medical organizations, including those providing psychiatric care. The changed conditions for the activities of medical organizations providing psychiatric care and the lack of standard labor standards for psychiatrists led to a study aimed at studying the costs of working time for work related to a patient visiting a local psychiatrist. We have developed and implemented norms of time for one visit by a patient to a local psychiatrist, which served as the basis for determining the load standards and the number of data of specialist doctorsОдной из основных задач отечественного здравоохранения является рациональное использование финансовых, материально-технических и кадровых ресурсов, с учетом медико-экономической эффективности проводимых мероприятий. Важным разделом в данном направлении является оптимизация штатного расписания медицинской организации исходя из потребностей в медицинской помощи и актуальных типовых норм труда. Одним из главных инструментов формирования штатного расписания является нормирование труда, организация и внедрение которого становиться все более актуальным в современных условиях деятельности медицинских организаций, в том числе оказывающих психиатрическую помощь. Изменившиеся условия деятельности медицинских организаций, оказывающих психиатрическую помощь и отсутствие типовых норм труда для врачей-психиатров обусловили проведение исследования, направленного на изучение затрат рабочего времени на оказание первичной медико-санитарной помощи больным с психическими заболеваниями. Нами разработаны и внедрены нормы времени на одно посещение пациентом участкового врача-психиатра, что послужило основой для определения норм нагрузки и численности данных врачей-специалисто