2-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methyl­idene]indan-1,3-dione

In the title compound, C21H16N2O2, the five-membered heterocyclic ring makes a dihedral angle of 47.06 (6)° with the attached benzene ring, whereas the indan-1,3-dione ring system and the benzene ring are oriented at a dihedral angle of 21.92 (7)°. In the crystal, inversion dimers linked by pairs of C—H⋯O hydrogen bonds generate R 2 2(22) loops. Aromatic π–π stacking inter­actions [centroid–centroid distances = 3.8325 (12)–3.8600 (12) Å] also occur

Cenozoic Antarctic DiatomWare/BugCam: An aid for research and teaching

Cenozoic Antarctic DiatomWare/BugCam© is an interactive, icon-driven digital-imagedatabase/software package that displays over 500 illustrated Cenozoic Antarctic diatom taxa along with original descriptions (including over 100 generic and 20 family-group descriptions). This digital catalog is designed primarily for use by micropaleontologists working in the field (at sea or on the Antarctic continent) where hard-copy literature resources are limited. This new package will also be useful for classroom/lab teaching as well as for any paleontologists making or refining taxonomic identifications at the microscope. The database (Cenozoic Antarctic DiatomWare) is displayed via a custom software program (BugCam) written in Visual Basic for use on PCs running Windows 95 or later operating systems. BugCam is a flexible image display program that utilizes an intuitive thumbnail “tree” structure for navigation through the database. The data are stored on Micrsosoft EXCEL spread sheets, hence no separate relational database program is necessary to run the package

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16, 17 vs. 8.7 g crude protein/MJ metabolizable energy) from d 0 to 65 gestation (term, ∼ 145 d). Effects on the maternal and fetal nutritional environment were characterized by sampling blood and amniotic fluid. Kidney development was characterized by histology, immunohistochemistry, vascular corrosion casts, and molecular biology. PEM had little measureable effect on maternal and fetal macronutrient balance (glucose, total protein, total amino acids, and lactate were unaffected) or on fetal growth. PEM decreased maternal and fetal urea concentration, which blunted fetal ornithine availability and affected fetal hepatic polyamine production. For the first time in a large animal model, we associated these nutritional effects with reduced micro- but not macrovascular development in the fetal kidney. Maternal PEM specifically impacts the fetal ornithine cycle, affecting cellular polyamine metabolism and microvascular development of the fetal kidney, effects that likely underpin programming of kidney development and function by a maternal low protein diet

Sensitivity of the West Antarctic Ice Sheet to +2 °C (SWAIS 2C)

The West Antarctic Ice Sheet (WAIS) presently holds enough ice to raise global sea level by 4.3 m if completely melted. The unknown response of the WAIS to future warming remains a significant challenge for numerical models in quantifying predictions of future sea level rise. Sea level rise is one of the clearest planet-wide signals of human-induced climate change. The Sensitivity of the West Antarctic Ice Sheet to a Warming of 2 °C (SWAIS 2C) Project aims to understand past and current drivers and thresholds of WAIS dynamics to improve projections of the rate and size of ice sheet changes under a range of elevated greenhouse gas levels in the atmosphere as well as the associated average global temperature scenarios to and beyond the +2 °C target of the Paris Climate Agreement. Despite efforts through previous land and ship-based drilling on and along the Antarctic margin, unequivocal evidence of major WAIS retreat or collapse and its causes has remained elusive. To evaluate and plan for the interdisciplinary scientific opportunities and engineering challenges that an International Continental Drilling Program (ICDP) project along the Siple coast near the grounding zone of the WAIS could offer (Fig. 1), researchers, engineers, and logistics providers representing 10 countries held a virtual workshop in October 2020. This international partnership comprised of geologists, glaciologists, oceanographers, geophysicists, microbiologists, climate and ice sheet modelers, and engineers outlined specific research objectives and logistical challenges associated with the recovery of Neogene and Quaternary geological records from the West Antarctic interior adjacent to the Kamb Ice Stream and at Crary Ice Rise. New geophysical surveys at these locations have identified drilling targets in which new drilling technologies will allow for the recovery of up to 200 m of sediments beneath the ice sheet. Sub-ice-shelf records have so far proven difficult to obtain but are critical to better constrain marine ice sheet sensitivity to past and future increases in global mean surface temperature up to 2 °C above pre-industrial levels. Thus, the scientific and technological advances developed through this program will enable us to test whether WAIS collapsed during past intervals of warmth and determine its sensitivity to a +2 °C global warming threshold (UNFCCC, 2015).This research has been supported by the New Zealand Ministry of Business and Innovation and Employment through the Antarctic Science Platform contract (ANTA1801) Antarctic Ice Dynamics Project (grant no. ASP-021-01) and the US NSF (grant nos. 1443552, 2035035, 2034999, 2035138, and 2034883

Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies

Background: Tetrahydrobiopterin (BH4) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH4 biosynthesis or recycling. Hyperphenylalaninemia (HPA) is the first diagnostic hallmark for most BH4 deficiencies, apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency and sepiapterin reductase deficiency. Early supplementation of neurotransmitter precursors and where appropriate, treatment of HPA results in significant improvement of motor and cognitive function. Management approaches differ across the world and therefore these guidelines have been developed aiming to harmonize and optimize patient care. Representatives of the International Working Group on Neurotransmitter related Disorders (iNTD) developed the guidelines according to the SIGN (Scottish Intercollegiate Guidelines Network) methodology by evaluating all available evidence for the diagnosis and treatment of BH4 deficiencies. Conclusion: Although the total body of evidence in the literature was mainly rated as low or very low, these consensus guidelines will help to harmonize clinical practice and to standardize and improve care for BH4 deficient patients

A combined estimator using TEC and b-value for large earthquake prediction

[EN] Ionospheric anomalies have been shown to occur a few days before several large earthquakes. The published works normally address examples limited in time (a single event or few of them) or space (a particular geographic area), so that a clear method based on these anomalies which consistently yields the place and magnitude of the forthcoming earthquake, anytime and anywhere on earth, has not been presented so far. The current research is aimed at prediction of large earthquakes, that is with magnitude M-w 7 or higher. It uses as data bank all significant earthquakes occurred worldwide in the period from January 1, 2011 to December 31, 2018. The first purpose of the research is to improve the use of ionospheric anomalies in the form of TEC grids for earthquake prediction. A space-time TEC variation estimator especially designed for earthquake prediction will show the advantages with respect to the use of simple TEC values. Further, taking advantage of the well-known predictive abilities of the Gutenberg-Richter law's b-value, a combined estimator based on both TEC anomalies and b-values will be designed and shown to improve prediction performance even more.Baselga Moreno, S. (2020). A combined estimator using TEC and b-value for large earthquake prediction. Acta Geodaetica et Geophysica Hungarica. 55(1):63-82. https://doi.org/10.1007/s40328-019-00281-5S6382551Abordán A, Szabó NP (2018) Metropolis algorithm driven factor analysis for lithological characterization of shallow marine sediments. Acta Geod Geophys 53:189–199. https://doi.org/10.1007/s40328-017-0210-zAkhoondzadeh M, Saradjian MR (2011) TEC variations analysis concerning Haiti (January 12, 2010) and Samoa (September 29, 2009) earthquakes. Adv Space Res 47(1):94–104. https://doi.org/10.1016/j.asr.2010.07.024Asencio-Cortés G, Morales-Esteban A, Shang X, Martínez-Álvarez F (2018) Earthquake prediction in California using regression algorithms and cloud-based big data infrastructure. Comput Geosci 115:198–210. https://doi.org/10.1016/j.cageo.2017.10.011Baselga S (2018) Fibonacci lattices for the evaluation and optimization of map projections. Comput Geosci 117:1–8. https://doi.org/10.1016/j.cageo.2018.04.012Baselga S (2019) TestGrids: evaluating and optimizing map projections. J Surv Eng 144(3):04019004Berényi KA, Barta V, Kis Á (2018) Midlatitude ionospheric F2-layer response to eruptive solar events-caused geomagnetic disturbances over Hungary during the maximum of the solar cycle 24: a case study. Adv Space Res 61(5):1230–1243. https://doi.org/10.1016/j.asr.2017.12.021Biswas A, Sharma SP (2017) Interpretation of self-potential anomaly over 2-D inclined thick sheet structures and analysis of uncertainty using very fast simulated annealing global optimization. Acta Geod Geophys 52:439–455. https://doi.org/10.1007/s40328-016-0176-2Borgohain JM, Borah K, Biswas R, Bora DK (2018) Seismic b-value anomalies prior to the 3rd January 2016, Mw = 6.7 Manipur earthquake of northeast India. J Asian Earth Sci 154:42–48. https://doi.org/10.1016/j.jseaes.2017.12.013Buonsanto M (1999) Ionospheric storms—a review. Space Sci Rev 88:563–601. https://doi.org/10.1023/A:1005107532631Buskirk RE, Frohlich CL, Latham GV (1981) Unusual animal behavior before earthquakes: a review of possible sensory mechanisms. Rev Geophys 19:247–270. https://doi.org/10.1029/RG019i002p00247Dobrovolsky IR, Zubkov SI, Myachkin VI (1979) Estimation of the size of earthquake preparation zones. Pure appl Geophys 117:1025–1044. https://doi.org/10.1007/BF00876083Dogan U, Ergintav S, Skone S, Arslan N, Oz D (2011) Monitoring of the ionosphere TEC variations during the 17th August 1999 Izmit earthquake using GPS data. Earth Planets Space 63(12):1183–1192. https://doi.org/10.5047/eps.2011.07.020Florido E, Martínez-Álvarez F, Morales-Esteban A, Reyes J, Aznarte-Mellado JL (2015) Detecting precursory patterns to enhance earthquake prediction in Chile. Comput Geosci 76:112–120. https://doi.org/10.1016/j.cageo.2014.12.002Florido E, Asencio-Cortés G, Aznarte JL, Rubio-Escudero C, Martínez-Álvarez F (2018) A novel tree-based algorithm to discover seismic patterns in earthquake catalogs. Comput Geosci 115:96–104. https://doi.org/10.1016/j.cageo.2018.03.005Freund FT, Kulahci IG, Cyr G, Ling J, Winnick M, Tregloan-Reed J, Freund MM (2009) Air ionization at rock surfaces and pre-earthquake signals. J Atmos Sol Terr Phys 71(17–18):1824–1834. https://doi.org/10.1016/j.jastp.2009.07.013Gopinath S, Prince PR (2018) Nonextensive and distance-based entropy analysis on the influence of sunspot variability in magnetospheric dynamics. Acta Geod Geophys 53:639–659. https://doi.org/10.1007/s40328-018-0235-yGrant RA, Halliday T (2010) Predicting the unpredictable; evidence of pre-seismic anticipatory behaviour in the common toad. J Zool 281:263–271. https://doi.org/10.1111/j.1469-7998.2010.00700.xGrant RA, Halliday T, Balderer WP, Leuenberger F, Newcomer M, Cyr G, Freund FT (2011) Ground water chemistry changes before major earthquakes and possible effects on animals. Int J Environ Res Public Health 8:1936–1956. https://doi.org/10.3390/ijerph8061936Guo J, Yu H, Li W, Liu X, Kong Q, Zhao C (2017) Total electron content anomalies before Mw 6.0 + earthquakes in the seismic zone of southwest China between 2001 and 2013. J Test Eval 45(1):131–139. https://doi.org/10.1520/JTE20160032International GNSS Service (2019) IGS products. https://www.igs.org/products. Accessed 5 May 2019Kane RP (2005) Ionospheric foF2 anomalies during some intense geomagnetic storms. Ann Geophys 23:2487–2499. https://doi.org/10.5194/angeo-23-2487-2005Kulhanek O, Persson L, Nuannin P (2018) Variations of b-values preceding large earthquakes in the shallow subduction zones of Cocos and Nazca plates. J South Am Earth Sci 82:207–214. https://doi.org/10.1016/j.jsames.2018.01.005Lin JW (2010) Ionospheric total electron content (TEC) anomalies associated with earthquakes through Karhunen–Loéve Transform (KLT). Terr Atmos Ocean Sci 21(2):253–265. https://doi.org/10.3319/TAO.2009.06.11.01(T)Lin JW (2011) Latitude-time total electron content anomalies as precursors to Japan’s large earthquakes associated with principal component analysis. Int J Geophys. https://doi.org/10.1155/2011/763527Liu JY, Chen YI, Chuo YJ, Chen CS (2006) A statistical investigation of preearthquake ionospheric anomaly. J Geophys Res 111:A05304. https://doi.org/10.1029/2005JA011333Liu JY, Chen YI, Chen CH, Liu CY, Chen CY, Nishihashi M, Li JZ, Xia YQ, Oyama KI, Hattori K, Lin CH (2009) Seismoionospheric GPS total electron content anomalies observed before the 12 May 2008 Mw7.9 Wenchuan earthquake. J Geophys Res 114:A04320. https://doi.org/10.1029/2008JA013698Nuannin P, Kulhanek O, Persson L (2005) Spatial and temporal b value anomalies preceding the devastating off coast of NW Sumatra earthquake of December 26, 2004. Geophys Res Lett 32:L11307. https://doi.org/10.1029/2005GL022679Pardalos PM, Romeijn HE (eds) (2002) Handbook of global optimization, vols. 1 & 2. Kluwer, DordretchPaul B, De BK, Guha A (2018) Latitudinal variation of F-region ionospheric response during three strongest geomagnetic storms of 2015. Acta Geod Geophys 53:579–606. https://doi.org/10.1007/s40328-018-0221-4Pulinets S, Boyarchuk K (2004) Ionospheric precursors of earthquakes. Springer, BerlinPulinets SA, Legen’ka AD, Gaivoronskaya TV, Depuev VKh (2003) Main phenomenological features of ionospheric precursors of strong earthquakes. J Atmos Sol Terr Phys 65:1337–1347. https://doi.org/10.1016/j.jastp.2003.07.011Reyes J, Morales-Esteban A, Martínez-Álvarez F (2013) Neural networks to predict earthquakes in Chile. Appl Soft Comput 13:1314–1328. https://doi.org/10.1016/j.asoc.2012.10.014Şentürk E, Çepni MS (2018a) A statistical analysis of seismo ionospheric TEC anomalies before 63 Mw ≥ 5.0 earthquakes in Turkey during 2003–2016. Acta Geophys 66:1495–1507. https://doi.org/10.1007/s11600-018-0214-2Şentürk E, Çepni MS (2018b) Ionospheric temporal variations over the region of Turkey: a study based on long-time TEC observations. Acta Geod Geophys 53:623–637. https://doi.org/10.1007/s40328-018-0233-0Şentürk E, Çepni MS (2019) Performance of different weighting and surface fitting techniques on station-wise TEC calculation and modified sine weighting supported by the sun effect. J Spat Sci 64(2):209–220. https://doi.org/10.1080/14498596.2017.1417169Şentürk E, Livaoğlu H, Çepni MS (2019) A comprehensive analysis of ionospheric anomalies before the mw 7.1 Van earthquake on 23 October 2011. J Navig 72(3):702–720. https://doi.org/10.1017/S0373463318000826Shiuly A, Roy N (2018) A generalized VS–N correlation using various regression analysis and genetic algorithm. Acta Geod Geophys 53:479–502. https://doi.org/10.1007/s40328-018-0220-5U.S. Geological Survey (2019) Earthquake catalog. https://earthquake.usgs.gov/earthquakes/search/. Accessed 5 May 2019Warwick JW, Stoker C, Meyer TR (1982) Radio emission associated with rock fracture: possible application to the Great Chilean Earthquake of May 22, 1960. J Geophys Res Solid Earth 87:2851–2859. https://doi.org/10.1029/JB087iB04p02851Yao Y, Chen P, Wu H, Zhang S, Peng W (2012) Analysis of ionospheric anomalies before the 2011 M w 9.0 Japan earthquake. Chin Sci Bull 57(5):500–510. https://doi.org/10.1007/s11434-011-4851-yZakharenkova IE, Shagimuratov II, Krankowski A (2007a) Features of the ionosphere behavior before the Kythira 2006 earthquake. Acta Geophys 55(4):524–534. https://doi.org/10.2478/s11600-007-0031-5Zakharenkova IE, Shagimuratov II, Krankowski A, Lagovsky AF (2007b) Precursory phenomena observed in the total electron content measurements before great Hokkaido earthquake of September 25, 2003 (M = 8.3). Stud Geophys Geod 51(2):267–278. https://doi.org/10.1007/s11200-007-0014-

Sensitivity of the West Antarctic Ice Sheet to +2 °C (SWAIS 2C)

The West Antarctic Ice Sheet (WAIS) presently holds enough ice to raise global sea level by 4.3 m if completely melted. The unknown response of the WAIS to future warming remains a significant challenge for numerical models in quantifying predictions of future sea level rise. Sea level rise is one of the clearest planet-wide signals of human-induced climate change. The Sensitivity of the West Antarctic Ice Sheet to a Warming of 2 ∘C (SWAIS 2C) Project aims to understand past and current drivers and thresholds of WAIS dynamics to improve projections of the rate and size of ice sheet changes under a range of elevated greenhouse gas levels in the atmosphere as well as the associated average global temperature scenarios to and beyond the +2 ∘C target of the Paris Climate Agreement. Despite efforts through previous land and ship-based drilling on and along the Antarctic margin, unequivocal evidence of major WAIS retreat or collapse and its causes has remained elusive. To evaluate and plan for the interdisciplinary scientific opportunities and engineering challenges that an International Continental Drilling Program (ICDP) project along the Siple coast near the grounding zone of the WAIS could offer (Fig. 1), researchers, engineers, and logistics providers representing 10 countries held a virtual workshop in October 2020. This international partnership comprised of geologists, glaciologists, oceanographers, geophysicists, microbiologists, climate and ice sheet modelers, and engineers outlined specific research objectives and logistical challenges associated with the recovery of Neogene and Quaternary geological records from the West Antarctic interior adjacent to the Kamb Ice Stream and at Crary Ice Rise. New geophysical surveys at these locations have identified drilling targets in which new drilling technologies will allow for the recovery of up to 200 m of sediments beneath the ice sheet. Sub-ice-shelf records have so far proven difficult to obtain but are critical to better constrain marine ice sheet sensitivity to past and future increases in global mean surface temperature up to 2 ∘C above pre-industrial levels. Thus, the scientific and technological advances developed through this program will enable us to test whether WAIS collapsed during past intervals of warmth and determine its sensitivity to a +2 ∘C global warming threshold (UNFCCC, 2015)

Expedition 392 summary

During International Ocean Discovery Program Expedition 392, three sites were drilled on the Agulhas Plateau and one site was drilled in the Transkei Basin in the Southwest Indian Ocean. This region was positioned at paleolatitudes of ~53°–61°S during the Late Cretaceous (van Hinsbergen et al., 2015) (100–66 Ma) and within the new and evolving gateway between the South Atlantic, Southern Ocean, and southern Indian Ocean basins. Recovery of basement rocks and sedimentary sequences from the Agulhas Plateau sites and a thick sedimentary sequence in the Transkei Basin provides a wealth of new data to (1) determine the nature, origin, and bathymetric evolution of the Agulhas Plateau; (2) significantly advance the understanding of how Cretaceous temperatures, ocean circulation, and sedimentation patterns evolved as CO2 levels rose and fell and the breakup of Gondwana progressed; (3) document long- and short-term paleoceanographic variability through the Late Cretaceous and Paleogene; and (4) investigate geochemical interactions between igneous rocks, sediments, and pore waters through the life cycle of a large igneous province (LIP). Importantly, postcruise analysis of Expedition 392 drill cores will allow testing of competing hypotheses concerning Agulhas Plateau LIP formation and the role of deep ocean circulation changes through southern gateways in influencing Late Cretaceous–early Paleogene climate evolution