20 research outputs found
Candidate genes in quantitative trait loci associated with absolute and relative kidney weight in rats with Inherited Stress Induced Arterial Hypertension
Get PDFThe gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension
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Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension
Full text linkTHE DOWNREGULATION OF GENES CONTROLLING VASCULAR TONE IN KIDNEYS OF ISIAH RATS WITH STRESS-INDUCED ARTERIAL HYPERTENSION
No full textThe transcriptional activity of genes was studied in kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in kidneys of just one of the analyzed strains. Gene profiling was performed on the Illumina RatRef-12 Expression BeadChip microarray platform. The expression of three genes (Klk1, Klk1c10, and Kng1) related to the kallikrein-kinin system was significant in the WAG renal cortex but was not detected in hypertensive kidneys. The downregulation of these three genes and Gucy1a3 in ISIAH renal cortex suggests the weakened function of the kallikrein-kinin system in hypertensive kidneys, which may cause blood circulation disturbances in renal glomeruli and mediate the development of hypertension in ISIAH rats. The functional annotation of the genes significantly expressed in renal medulla of just one of the compared rat strains revealed the genes involved in immune response regulation
A New Redox Method for Depositing FeOx on the Surface of Pd(0)/SiO2 Nanoparticles—Catalysts for Selective Phenylacetylene Hydrogenation
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Low-temperature copper hydrosilicates: catalysts for reduction of aromatic nitro compounds with molecular hydrogen
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